Einzeltreffer — DigiBib

Mitochondria participate in the maintenance of cellular homeostasis. Firstly, mitochondria regulate energy metabolism through oxidative phosphorylation. In addition, they are involved in cell fate decisions by activating the apoptotic intrinsic pathway. Finally, they work as intracellular signaling hubs as a result of their tight regulation of ion and metabolite concentrations and other critical signaling molecules such as ROS. Aging is a multifactorial process triggered by impairments in different cellular components. Among the various molecular pathways involved, mitochondria are key regulators of longevity. Indeed, mitochondrial deterioration is a critical signature of the aging process. In this scenario, we will focus specifically on the age-related decrease in CoQ levels, an essential component of the electron transport chain (ETC) and an antioxidant, and how CoQ supplementation could benefit the aging process. Generally, any treatment that improves and sustains mitochondrial functionality is a good candidate to counteract age-related mitochondrial dysfunctions. In recent years, heightened attention has been given to natural compounds that modulate mitochondrial function. One of the most famous is resveratrol due to its ability to increase mitochondrial biogenesis and work as an antioxidant agent. This review will discuss recent clinical trials and meta-analyses based on resveratrol and CoQ supplementation, focusing on how these compounds could improve mitochondrial functionality during aging.

Titel:	CoQ <subscript>10</subscript> and Resveratrol Effects to Ameliorate Aged-Related Mitochondrial Dysfunctions.
Autor/in / Beteiligte Person:	Gherardi, G ; Corbioli, G ; Ruzza, F ; Rizzuto, R
Link:	Full Text Finder (Volltext)
Zeitschrift:	Nutrients, Jg. 14 (2022-10-16), Heft 20
Veröffentlichung:	Basel, Switzerland : MDPI Publishing, 2022
Medientyp:	academicJournal
ISSN:	2072-6643 (electronic)
DOI:	10.3390/nu14204326
Schlagwort:	Resveratrol pharmacology Resveratrol metabolism Reactive Oxygen Species metabolism Oxidative Phosphorylation Oxidative Stress Antioxidants pharmacology Antioxidants metabolism Mitochondria metabolism
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(PMID: 22055505) ; J Inherit Metab Dis. 2015 Jan;38(1):145-56. (PMID: 25091424) ; Biochem J. 1995 Aug 1;309 ( Pt 3):883-90. (PMID: 7639706) ; Atherosclerosis. 2018 Mar;270:123-131. (PMID: 29407880) Grant Information: GHER_BIRD2222_01 Dept. of Biomedical sciences, UNIPD; Eccellenza2018 Bando Ricerca Scientifica di Eccellenza 2018 della Fondazione Cassa di Risparmio di Padova e Rovigo; 22759 AIRC Programma di ricerca 5 per Mille 2019; 2020R2BP2E_002 MIUR PRIN 2020; RF-2016-02363566 Progetto ricerca sanitaria finalizzata Rep. 100/2019; Eccellenza2017 Bando Ricerca Scientifica di Eccellenza 2017 della Fondazione Cassa di Risparmio di Padova e Rovigo Contributed Indexing: Keywords: aging; coenzymeQ10; mitochondria; resveratrol Substance Nomenclature: Q369O8926L (Resveratrol) ; 0 (Antioxidants) ; 0 (Reactive Oxygen Species) Entry Date(s): Date Created: 20221027 Date Completed: 20221028 Latest Revision: 20221030 Update Code: 20240513 PubMed Central ID: PMC9611139

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CoQ <subscript>10</subscript> and Resveratrol Effects to Ameliorate Aged-Related Mitochondrial Dysfunctions.