Einzeltreffer — DigiBib

Objective: This study aimed to investigate the prognostic factors and treatment outcomes in patients with the external auditory canal (EAC) squamous cell carcinoma (SCC).

Methods: All patients diagnosed with EAC SCC and treated with curative intent at a single tertiary institution were retrospectively reviewed over a 22-year period. Treatment modalities included surgery with adjuvant treatment or definitive radiotherapy. The primary endpoints were overall survival (OS) and disease-specific survival (DSS).

Results: There were 51 patients in our cohort. The 5-year OS and DSS were 64.0% ± 7.0% and 72.0% ± 7.0% respectively. Patients in the surgical arm and RT arm showed no significant difference in OS, DSS, and LRFS (p = 0.075, 0.062, 0.058 respectively). Compared to other routes of spread within the temporal bone, pattern of posterior disease invasion (involving mastoid/sigmoid sinus) showed poorer OS and DSS on multivariate analysis (hazard ratio, HR4.34 and 5.88; p = 0.006 and 0.009). On multivariate analysis, the following factors were independently prognostic of poorer OS and DSS: Previous radiotherapy (HR 3.29 and 4.81, p = 0.021 and p = 0.029); Presence of facial nerve palsy (HR 3.80 and 7.63, p = 0.013 and p = 0.003); Posterior pattern of invasion (HR4.05 and 3.59, p = 0.013 and p = 0.043). Advanced modified Pittsburgh stage was not predictive of poor OS and DSS (HR1.17 and 1.17 E+5, p = 0.786 and p = 0.961).

Conclusion: Presence of previous radiotherapy, facial nerve palsy and posterior pattern of disease invasion were independent prognostic factors of poorer survival in patients with EAC SCC.

Level of Evidence: 4 Laryngoscope, 133:2203-2210, 2023.

Titel:	Analysis of Prognostic Factors For External Auditory Canal Carcinoma: A 22-Year Experience.
Autor/in / Beteiligte Person:	Jang, IJH ; Thong, JF ; Teo, CEH ; Sommat, K
Link:	Full Text Finder (Volltext)
Zeitschrift:	The Laryngoscope, Jg. 133 (2023-09-01), Heft 9, S. 2203-2210
Veröffentlichung:	<2009- >: Philadelphia, PA : Wiley-Blackwell ; <i>Original Publication</i>: St. Louis, Mo. : [s.n., 1896-, 2023
Medientyp:	academicJournal
ISSN:	1531-4995 (electronic)
DOI:	10.1002/lary.30504
Schlagwort:	Humans Prognosis Retrospective Studies Neoplasm Staging Paralysis pathology Ear Canal surgery Carcinoma, Squamous Cell pathology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Laryngoscope] 2023 Sep; Vol. 133 (9), pp. 2203-2210. <i>Date of Electronic Publication: </i>2022 Dec 07. MeSH Terms: Ear Canal* / surgery ; Carcinoma, Squamous Cell* / pathology ; Humans ; Prognosis ; Retrospective Studies ; Neoplasm Staging ; Paralysis / pathology References: Manolidis S, Pappas D Jr, Von DP, et al. Temporal bone and lateral skull base malignancy: experience and results with 81 patients. Am J Otol. 1998;19(6):1-15. ; Waldemar E, Sørensen T, Bretlau P, Hansen HS. Cancer in the middle ear and the auditory canal. Ugeskr Laeger. 1995;157:2139-2142. ; Leonetti JP, Smith PG, Kletzker GR, Izquierdo R. Invasion patterns of advanced temporal bone malignancies. Am J Otol. 1996;17(3):438-442. ; Amin MB, Edge S, Greene F, et al., eds. AJCC Cancer Staging Manual (8th edition). Springer International Publishing: American Joint Commission on Cancer; 2017 [cited 2021 Nov 16]. ; Moody SA, Hirsch BE, Myers EN. Squamous cell carcinoma of the external auditory canal: an evaluation of a staging system. Am J Otol. 2000;21:582-588. ; Arriaga M, Hirsch BE, Kamerer DB, Myers EN. Squamous cell carcinoma of the external auditory meatus (canal). Otolaryngol Head Neck Surg. 1989;101:330-337. ; Stell PM, McCormick MS. Carcinoma of the external auditory meatus and middle ear. Prognostic factors and a suggested staging system. J Laryngol Otol. 1985;99:847-850. ; Bacciu A, Clemente IA, Piccirillo E, Ferrari S, Sanna M. Guidelines for treating temporal bone carcinoma based on long-term outcomes. Otol Neurotol. 2013;34(5):898-907. ; Prasad S, D'Orazio F, Medina M, Bacciu A, Sanna M. State of the art in temporal bone malignancies. Curr Opin Otolaryngol Head Neck Surg. 2014;22:154-165. ; Zanoletti E, Marioni G, Stritoni P, et al. Temporal bone squamous cell carcinoma: analyzing prognosis with univariate and multivariate models. Laryngoscope. 2014;124(5):1192-1198. ; Zanoletti E, Lovato A, Stritoni P, Martini A, Mazzoni A, Marioni G. A critical look at persistent problems in the diagnosis, staging and treat- ment of temporal bone carcinoma. Cancer Treat Rev. 2015;41(10):821-826. ; Pfreundner L, Schwager K, Willner J, et al. Carcinoma of the external auditory canal and middle ear. Int J Radiat Oncol Biol Phys. 1999;44:777-788. ; Pemberton LS, Swindell R, Sykes AJ. Primary radical radiotherapy for squamous cell carcinoma of the middle ear and external auditory canal - an historical series. Clin Oncol. 2006;18:390-394. ; Ogawa K, Nakamura K, Hatano K, et al. Treatment and prognosis of squamous cell carcinoma of the external auditory canal and middle ear: a multi-institutional retrospective review of 87 patients. Int J Radiat Oncol Biol Phys. 2007;68:1326-1334. ; Takenaka Y, Cho H, Nakahara S, Yamamoto Y, Yasui T, Inohara H. Chemoradiation therapy for squamous cell carcinoma of the external auditory canal: a meta-analysis. Head Neck. 2015;37:1073-1080. ; Chi FL, Gu FM, Dai CF, Chen B, Li HW. Survival outcomes in surgical treatment of 72 cases of squamous cell carcinoma of the temporal bone. Otol Neurotol. 2011;32(4):665-669. ; Austin JR, Stewart KL, Fawzi N. Squamous cell carcinoma of the external auditory canal. Therapeutic prognosis based on a proposed staging system. Arch Otolaryngol Head Neck Surg. 1994;120(11):1228-1232. ; Nagano T, Yoshimura R, Kojima M, Nakagawa K, Toda K. Outcomes of radiotherapy in advanced external auditory canal cancer. J Radiat Res. 2019;60:380-386. ; Shiga K, Katagiri K, Saitoh D, Ogawa T, Higashi K, Ariga H. Long-term outcomes of patients with squamous cell carcinoma of the temporal bone after concomitant chemoradiotherapy. J Neurol Surg B Skull Base. 2018;79:S316-S321. ; Shinomiya H, Hasegawa S, Yamashita D, et al. Concomitant chemoradiotherapy for advanced squamous cell carcinoma of the temporal bone. Head Neck. 2016;38:E949-E953. ; Shiga K, Nibu KI, Fujimoto Y, et al. Multi-institutional survey of squamous cell carcinoma of the external Auditory Canal in Japan. Laryngoscope. 2021;131(3):E870-E874. ; Ferlay J, Soerjomataram I, Ervik M, et al. GLOBOCAN 2020 v1.0, Cancer incidence and mortality worldwide: IARC Cancer Base No. 11. Accessed January 23, 2022. http://globocan.iarc.fr/Default.aspx. ; Lionello M, Stritoni P, Facciolo MC, et al. Temporal bone carcinoma. Current diagnostic, therapeutic, and prognostic concepts. J Surg Oncol. 2014;110:383-392. ; Mazzoni A, Zanoletti E, Marioni G, Martini A. En bloc temporal bone resections in squamous cell carcinoma of the ear. Technique, principles and limits. Acta Otolaryngol. 2016;136:425-432. ; National Comprehensive Cancer Network. Head and Neck Cancers. (Version 1.2022). Accessed March 30, 2022. https://www.nccn.org/professionals/physician_gls/pdf/head-and-neck.pdf. ; Oken MM, Creech RH, Tormey DC, et al. Toxicity and response criteria of the eastern cooperative oncology group. Am J Clin Oncol. 1982;5(6):649-655. ; Kallogjeri D, Piccirillo JF, Spitznagel EL, Steyerberg EW. Comparison of scoring Methods for ACE-27: simpler is better. J Geriat Oncol. 2012;3(3):238-245. ; Zhang T, Li W, Dai C, Chi F, Wang S, Wang Z. Evidence-based surgical management of T1 or T2 temporal bone malignancies. Laryngoscope. 2013;123(1):244-248. ; Higgins TS, Antonio SA. The role of facial palsy in staging squamous cell carcinoma of the temporal bone and external auditory canal: a comparative survival analysis. Otol Neurotol. 2010;31(9):1473-1479. ; Seligman KL, Sun DQ, Ten Eyck PP, Schularick NM, Hansen MR. Temporal bone carcinoma: treatment patterns and survival. Laryngoscope. 2020;130(1):E11-E20. ; Zanoletti E, Franz L, Cazzador D, et al. Temporal bone carcinoma: novel prognostic score based on clinical and histological features. Head Neck. 2020;42(12):3693-3701. ; Franz L, Zanoletti E, Franchella S, et al. Temporal bone carcinoma: testing the prognostic value of a novel clinical and histological scoring system. Eur Arch Otorhinolaryngol. 2021;278(11):4179-4186. ; Omura G, Ando M, Saito Y, et al. Survival impact of local extension sites in surgically treated patients with temporal bone squamous cell carcinoma. Int J Clin Oncol. 2017;22:431-437. ; Smit CF, de Boer N, Lissenberg-Witte BI, Merkus P, Hensen EF, Leemans CR. Surgical treatment for squamous cell carcinoma of the temporal bone: predictors of survival. Acta Otorhinolaryngol Ital. 2021;41(4):308-316. ; Choi J, Kim SH, Koh YW, Choi EC, Lee CG, Keum KC. Tumor stage-related role of radiotherapy in patients with an external Auditory Canal and middle ear carcinoma. Cancer Res Treat. 2017;49(1):178-184. Contributed Indexing: Keywords: external auditory canal squamous cell carcinoma; prognostic factors; survival outcomes; temporal bone squamous cell carcinoma Entry Date(s): Date Created: 20221208 Date Completed: 20230811 Latest Revision: 20230830 Update Code: 20231215

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Analysis of Prognostic Factors For External Auditory Canal Carcinoma: A 22-Year Experience.