ReS <subscript>2</subscript> @Au NPs as signal labels quenching steady photocurrent generated by NiCo <subscript>2</subscript> O <subscript>4</subscript> /CdIn <subscript>2</subscript> S <subscript>4</subscript> /In <subscript>2</subscript> S <subscript>3</subscript> heterojunction for sensitive detection of CYFRA 21-1.

Zhang, Y ; Wu, T ; et al.

In: Biosensors & bioelectronics, Jg. 222 (2023-02-15), S. 114992

academicJournal

In order to achieve rapid and sensitive detection of CYFRA 21-1, a signal-off photoelectrochemical (PEC) immunosensor was devised with NiCo 2 O 4 /CdIn 2 S 4 /In 2 S 3 heterojunction photoactive materials as sensing platform and ReS 2 @Au NPs as the secondary antibody labels amplifying signal based on the energy band-matching cascade structure and double suppression effect. NiCo 2 O 4 possessed a faster charge transfer rate due to the abundance of redox electron pairs (Co 3+ /Co 2+ and Ni 3+ /Ni 2+ ). To further improve the PEC properties of NiCo 2 O 4 under visible light, CdIn 2 S 4 with matching bandgap energy was selected to form heterojunction with NiCo 2 O 4 and sensitized with In 2 S 3 . The proposed heterojunctions with well-matched band structure promoted the transfer of photo-generated carriers and were exploited as signal transducers for immobilization of antibodies and recognition of CYFRA 21-1. Furthermore, a novel urchin-like p-type ReS 2 semiconductor nanostructure functionalized by Au NPs was firstly used as a nanolabel to quench the signal. On the one hand, the Schottky heterojunction generated by ReS 2 and Au NPs could compete with the transducer substrate for both light and electron donors. On the other hand, the large space steric hindrance of ReS 2 prevented contact between the matrix and AA. Subsequently, the sensor was sensitive in a wide range of concentrations for CYFRA 21-1 (0.0001-50 ng/mL), and the detection limit was 0.05 pg/mL.

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Titel:	ReS <subscript>2</subscript> @Au NPs as signal labels quenching steady photocurrent generated by NiCo <subscript>2</subscript> O <subscript>4</subscript> /CdIn <subscript>2</subscript> S <subscript>4</subscript> /In <subscript>2</subscript> S <subscript>3</subscript> heterojunction for sensitive detection of CYFRA 21-1.
Autor/in / Beteiligte Person:	Zhang, Y ; Wu, T ; Cui, Q ; Qu, Z ; Ma, H ; Wei, Q
Zeitschrift:	Biosensors & bioelectronics, Jg. 222 (2023-02-15), S. 114992
Veröffentlichung:	Oxford : Elsevier Advanced Technology ; <i>Original Publication</i>: [Barking, Essex, England] : Elsevier Applied Science, 1989-, 2023
Medientyp:	academicJournal
ISSN:	1873-4235 (electronic)
DOI:	10.1016/j.bios.2022.114992
Schlagwort:	Humans Male Immunoassay Antibodies Prostate-Specific Antigen Electrochemical Techniques Limit of Detection Biosensing Techniques
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Biosens Bioelectron] 2023 Feb 15; Vol. 222, pp. 114992. <i>Date of Electronic Publication: </i>2022 Dec 06. MeSH Terms: Biosensing Techniques* ; Humans ; Male ; Immunoassay ; Antibodies ; Prostate-Specific Antigen ; Electrochemical Techniques ; Limit of Detection Contributed Indexing: Keywords: NiCo(2)O(4)/CdIn(2)S(4)/In(2)S(3); PEC immunosensor; ReS(2)@Au NPs; Schottky heterojunction; Signal-off Substance Nomenclature: 0 (antigen CYFRA21.1) ; 0 (Antibodies) ; EC 3.4.21.77 (Prostate-Specific Antigen) Entry Date(s): Date Created: 20221210 Date Completed: 20221227 Latest Revision: 20221230 Update Code: 20231215

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