Vascular complications in 305 severely ill patients with COVID-19: a cohort study.
In: Sao Paulo medical journal = Revista paulista de medicina, Jg. 141 (2022-12-19), Heft 5, S. e2022171
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Zugriff:
Background: Although an association has been made between coronavirus disease 2019 (COVID-19) and microvascular disease, data on vascular complications (other than venous thromboembolism) are sparse.
Objective: To investigate the vascular complications in severely ill patients hospitalized with COVID-19 and their association with all-cause mortality.
Design and Setting: This cohort study was conducted at the Universidade Federal de São Paulo, Brazil.
Methods: All 305 consecutive patients diagnosed with COVID-19 and hospitalized in the intensive care unit (ICU) of a tertiary university hospital from April 2 to July 17, 2021, were included and followed up for 30 days.
Results: Of these, 193 (63.3%) were male, and the mean age was 59.9 years (standard deviation = 14.34). The mortality rate was 56.3% (172 patients), and 72 (23.6%) patients developed at least one vascular complication during the follow-up period. Vascular complications were more prevalent in the non-survivors (28.5%) than in the survivors (17.3%) group and included disseminated intravascular coagulation (DIC, 10.8%), deep vein thrombosis (8.2%), acrocyanosis (7.5%), and necrosis of the extremities (2%). DIC (adjusted odds ratio (aOR) 2.30, 95% confidence interval (CI) 1.01-5.24, P = 0.046) and acrocyanosis (aOR 5.21, 95% CI 1.48-18.27, P = 0.009) were significantly more prevalent in the non-survivors than in the survivors group.
Conclusion: Vascular complications in critically ill COVID-19 patients are common (23.6%) and can be closely related to the mortality rate (56.3%) until 30 days after ICU admission. Macrovascular complications have direct implications for mortality, which is the main outcome of the management of COVID-19.
Registration: RBR-4qjzh7 (https://ensaiosclinicos.gov.br/rg/RBR-4qjzh7).
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Vascular complications in 305 severely ill patients with COVID-19: a cohort study.
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Autor/in / Beteiligte Person: | Correia, RM ; Santos, BC ; Carvalho, AAG ; Areias, LL ; Kuramoto, DAB ; Pereda, MR ; Aidar, ALES ; Clezar, CNB ; Reicher, ME ; Amorim, JE ; Flumignan, RLG ; Nakano, LCU |
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Zeitschrift: | Sao Paulo medical journal = Revista paulista de medicina, Jg. 141 (2022-12-19), Heft 5, S. e2022171 |
Veröffentlichung: | São Paulo, S.P., Brazil : Associação Paulista de Medicina, [1994-, 2022 |
Medientyp: | academicJournal |
ISSN: | 1806-9460 (electronic) |
DOI: | 10.1590/1516-3180.2022.0171.R2.17102022 |
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