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Context: The development and progression of Non-alcoholic Fatty Liver Disease (NAFLD) is associated with type 2 diabetes mellitus (T2DM), but there are no studies to demonstrate whether blood glucose levels are associated with the progression of NAFLD.

Objective: Alterations in glucose metabolism may cause hepatic steatosis and inflammatory responses, leading to hepatocyte damage and promoting NAFLD's progression. Since glycohemoglobin reflects current blood glucose levels and is easily detectable, the present study aimed to investigate whether glycohemoglobin is associated with liver stiffness in patients with NAFLD.

Methods: We studied 1510 NAFLD patients aged 20-80 in NHANES 2017- March 2020, who were defined using the controlled attenuation parameter (CAP) ≥263 dB/m. Multivariable linear regressions were used to assess the independent association between glycohemoglobin and median liver stiffness measurements (LSM) after adjusting for potential confounders. Subsequently, they were subjected to curve fitting and threshold effect analysis. Stratified analysis was used to find the variables affecting the relationship.

Results: Glycohemoglobin and median LSM showed a positive correlation in different models (β (95% CI): Crude Model: 1.460 (1.053, 1.867); Model 1: 1.476 (1.066, 1.885); Model 2: 1.517 (0.919, 2.115)), and this correlation disappeared when glycohemoglobin ≥8.6%. Furthermore, this correlation was more pronounced in the non-diabetic and former smoking subgroups.

Conclusion: In patients with NAFLD, glycohemoglobin may reflect the degree of liver stiffness, and preventing excessive glycohemoglobin may have a positive effect on slowing the progression of NAFLD especially in non-diabetic and former smokers.

Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Titel:	Glycohemoglobin: A new warning strategy for non-alcoholic fatty liver disease: Study from the NHANES 2017- 2020.
Autor/in / Beteiligte Person:	Hou, J ; Liu, Y ; Deng, Z ; Sun, J ; Zhao, M
Link:	Full Text Finder (Volltext)
Zeitschrift:	Frontiers in endocrinology, Jg. 13 (2022-12-22), S. 1078652
Veröffentlichung:	[Lausanne : Frontiers Research Foundation], 2022
Medientyp:	academicJournal
ISSN:	1664-2392 (print)
DOI:	10.3389/fendo.2022.1078652
Schlagwort:	Humans Glycated Hemoglobin Blood Glucose Nutrition Surveys Non-alcoholic Fatty Liver Disease metabolism Diabetes Mellitus, Type 2 complications
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Front Endocrinol (Lausanne)] 2022 Dec 22; Vol. 13, pp. 1078652. <i>Date of Electronic Publication: </i>2022 Dec 22 (<i>Print Publication: </i>2022). MeSH Terms: Non-alcoholic Fatty Liver Disease* / metabolism ; Diabetes Mellitus, Type 2* / complications ; Humans ; Glycated Hemoglobin ; Blood Glucose ; Nutrition Surveys References: Clin Gastroenterol Hepatol. 2019 Mar;17(4):748-755.e3. (PMID: 29908364) ; J Gastroenterol Hepatol. 2019 Aug;34(8):1396-1403. (PMID: 30551263) ; Gastroenterology. 2008 Feb;134(2):424-31. (PMID: 18242210) ; J Hepatol. 2011 Dec;55(6):1383-90. (PMID: 21703200) ; Diabetes Care. 2021 Feb;44(2):399-406. (PMID: 33355256) ; J Clin Invest. 2020 Mar 2;130(3):1453-1460. (PMID: 31805015) ; N Engl J Med. 2010 May 6;362(18):1675-85. (PMID: 20427778) ; Ann Intern Med. 2010 Jan 5;152(1):10-7. (PMID: 20048267) ; Clin Gastroenterol Hepatol. 2019 Jan;17(1):156-163.e2. (PMID: 29705261) ; Eur J Cardiovasc Prev Rehabil. 2006 Jun;13(3):334-40. (PMID: 16926661) ; Obes Res. 2003 Nov;11(11):1339-44. (PMID: 14627754) ; Gastroenterology. 2008 May;134(5):1369-75. (PMID: 18355813) ; Am J Gastroenterol. 2014 Mar;109(3):325-34. (PMID: 24445574) ; J Hepatol. 2018 Feb;68(2):268-279. (PMID: 29122391) ; Gastroenterology. 2011 Jan;140(1):124-31. (PMID: 20858492) ; Diabetes Care. 2001 Sep;24(9):1590-5. (PMID: 11522704) ; Hepatology. 1999 Dec;30(6):1356-62. (PMID: 10573511) ; Clin Gastroenterol Hepatol. 2022 Jun;20(6):e1438-e1455. (PMID: 34214678) ; Hepatology. 2016 Jul;64(1):73-84. (PMID: 26707365) ; Hepatology. 2005 Jun;41(6):1313-21. (PMID: 15915461) ; Clin Diabetes Endocrinol. 2020 Jun 05;6:9. (PMID: 32518675) ; Diabetes Care. 2018 Feb;41(2):372-382. (PMID: 29358469) ; Mol Metab. 2021 Aug;50:101167. (PMID: 33460786) ; JAMA. 2015 Jun 9;313(22):2263-73. (PMID: 26057287) ; Nat Rev Immunol. 2002 May;2(5):372-7. (PMID: 12033743) ; Gastroenterology. 2019 Apr;156(5):1264-1281.e4. (PMID: 30660725) ; J Hepatol. 2019 Mar;70(3):440-448. (PMID: 30389551) ; Am J Clin Nutr. 2011 May;93(5):1048-52. (PMID: 21367948) ; Gastroenterology. 2019 May;156(6):1717-1730. (PMID: 30689971) ; Gastroenterology. 2008 Oct;135(4):1176-84. (PMID: 18718471) ; Nat Rev Cardiol. 2021 Apr;18(4):291-304. (PMID: 33188304) ; Gastroenterology. 2000 Jun;118(6):1117-23. (PMID: 10833486) ; J Clin Invest. 2005 May;115(5):1343-51. (PMID: 15864352) Contributed Indexing: Keywords: NAFLD; NHANES; glycohemoglobin; liver stiffness; median LSM Substance Nomenclature: 0 (Glycated Hemoglobin) ; 0 (Blood Glucose) Entry Date(s): Date Created: 20230109 Date Completed: 20230110 Latest Revision: 20230127 Update Code: 20231215 PubMed Central ID: PMC9813781

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Glycohemoglobin: A new warning strategy for non-alcoholic fatty liver disease: Study from the NHANES 2017- 2020.