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- Nachgewiesen in: MEDLINE
- Sprachen: German
- Transliterated Title: HLA-B27-positive Uveitis anterior : Klinik, Diagnostik, interdisziplinäres Management und Therapie.
- Publication Type: English Abstract; Journal Article
- Language: German
- [Ophthalmologie] 2023 Jan; Vol. 120 (1), pp. 108-122. <i>Date of Electronic Publication: </i>2023 Jan 12.
- MeSH Terms: Uveitis, Anterior* / diagnosis ; Uveitis* ; Spondylarthritis* ; Young Adult ; Humans ; Adult ; HLA-B27 Antigen / genetics ; Inflammation ; Acute Disease
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- Contributed Indexing: Keywords: Acute anterior uveitis; Clinical manifestations; Psoriasis; Spondylarthritis; Systemic disease ; Local Abstract: [Publisher, German] Die mit dem humanen Leukozytenantigen(HLA)-B27 assoziierte, akute anteriore Uveitis (AAU) ist die häufigste Form nichtinfektiöser intraokulärer Entzündungen und wird als eigene klinische Entität gesehen. Es sind überwiegend junge Erwachsene im Alter zwischen 20 und 40 Jahren betroffen. Die HLA-B27-positive AAU präsentiert sich typischerweise als einseitige, fulminante Störung der Blut-Kammerwasser-Schranke, die mit einer ausgeprägten zellulären Infiltration und fibrinösen Exsudation einhergeht. Weitere Charakteristika sind ein verminderter Augeninnendruck und eine hohe Rezidivneigung, die auch das 2. Auge einbeziehen kann. Patienten mit HLA-B27-positiver AAU teilen ein hohes Risiko zu weiteren genetisch assoziierten Erkrankungen, insbesondere zu Spondyloarthritis, chronischer Darmerkrankung und Psoriasis. Da bei bis zu 40 % der Betroffenen eine bisher nicht diagnostizierte Systemerkrankung vorliegt, kommt dem Ophthalmologen eine wichtige Bedeutung bei der Früherkennung zu.
- Substance Nomenclature: 0 (HLA-B27 Antigen)
- Entry Date(s): Date Created: 20230112 Date Completed: 20230123 Latest Revision: 20231212
- Update Code: 20240513
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