Co-delivery of microRNA-150 and quercetin by lipid nanoparticles (LNPs) for the targeted treatment of age-related macular degeneration (AMD).
In: Journal of controlled release : official journal of the Controlled Release Society, Jg. 355 (2023-03-01), S. 358-370
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Zugriff:
Age-related macular degeneration (AMD) is characterized by choroidal neovascularization (CNV), which leads to severe vision loss in middle-aged and elderly patients. Current treatments for CNV show weak, transient efficacy, and they can cause several adverse effects. A potential new treatment is to use microRNA-150 (mR150), which regulates physiological and pathological angiogenesis by modulating the expression of CXCR4 at the post-transcriptional level. Here, we developed solid lipid nanoparticles that we modified with an Asp-Gly-Arg peptide to target endothelial cells during abnormal angiogenesis, then we co-loaded them with mR150 and the anti-angiogenic drug quercetin. The resulting nanoparticles had an average size around 200 nm and showed strong ability to target the fundus and inhibit CNV for up to two weeks in a mouse model without causing retinal toxicity. They significantly enhanced the uptake of mR150 in vitro compared to free mR150 or nanoparticles without peptide. Our study suggests that co-administration of mR150 and quercetin has potential for treating age-related macular degeneration and that nanoparticles modified with Asp-Gly-Arg peptide are an effective platform for the co-delivery of small-molecule and nucleic acid drugs via intravitreal injection.
Competing Interests: Declaration of Competing Interest The authors declare no conflicts of interest.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Titel: |
Co-delivery of microRNA-150 and quercetin by lipid nanoparticles (LNPs) for the targeted treatment of age-related macular degeneration (AMD).
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Autor/in / Beteiligte Person: | Li, W ; Chen, L ; Gu, Z ; Chen, Z ; Li, H ; Cheng, Z ; Zou, L |
Zeitschrift: | Journal of controlled release : official journal of the Controlled Release Society, Jg. 355 (2023-03-01), S. 358-370 |
Veröffentlichung: | Amsterdam : Elsevier Science Publishers, 1984-, 2023 |
Medientyp: | academicJournal |
ISSN: | 1873-4995 (electronic) |
DOI: | 10.1016/j.jconrel.2023.01.080 |
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