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Objective: The Zinc fingers and homeoboxes (ZHX) protein family has been reported to be involved in tumor development; however, it remains controversial whether these proteins can act as promoters or inhibitors of cancer development. The current study focused on the biological role of ZHX2 in ovarian cancer.

Methods: Tissue microarrays were established using 154 ovarian cancer samples. Immunohistochemical analysis was employed to determine the expression levels of ZHX2 in ovarian cancer samples. The prognostic analysis was performed using the Kaplan-Meier method and compared with a log-rank test. The specific role of ZHX2 in ovarian cancer was investigated in cell lines in vitro.

Results: It was found that ZHX2 was not significantly overexpressed in ovarian cancer samples; however, its expression was significantly correlated with advanced tumor grade. Patient survival analysis indicated that patients with high expression of ZHX2 exhibited worse overall survival rate compared with those with low expression of ZHX2. Furthermore, univariate and multivariate analyses demonstrated that ZHX2 was an independent prognostic factor of progression-free survival in patients with ovarian cancer. In vitro experiments indicated that inhibition of ZHX2 could significantly suppress ovarian cancer cell proliferation via induction of the apoptotic pathway.

Conclusions: The data indicated that ZHX2 may be considered a promising biomarker in ovarian cancer and that inhibition of its expression may be a potential therapeutic target in ovarian cancer treatment.

Titel:	Zinc fingers and homeoboxes 2 inhibition could suppress the proliferation of ovarian cancer cells by apoptosis pathway.
Autor/in / Beteiligte Person:	Ding, R ; Shi, H ; Guo, Y ; Zeng, W ; Fan, J
Link:	View record at Springer (Volltext)
Zeitschrift:	Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, Jg. 25 (2023-07-01), Heft 7, S. 2116-2126
Veröffentlichung:	<2010- >: Milan : Springer Italia ; <i>Original Publication</i>: Barcelona, Spain : Doyma, c2005-, 2023
Medientyp:	academicJournal
ISSN:	1699-3055 (electronic)
DOI:	10.1007/s12094-023-03090-z
Schlagwort:	Female Humans Apoptosis Cell Proliferation Zinc Fingers Genes, Homeobox Homeodomain Proteins genetics Ovarian Neoplasms drug therapy Transcription Factors genetics
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Clin Transl Oncol] 2023 Jul; Vol. 25 (7), pp. 2116-2126. <i>Date of Electronic Publication: </i>2023 Feb 06. MeSH Terms: Genes, Homeobox* ; Homeodomain Proteins* / genetics ; Ovarian Neoplasms* / drug therapy ; Transcription Factors* / genetics ; Female ; Humans ; Apoptosis ; Cell Proliferation ; Zinc Fingers References: Tirpe AA, Gulei D, Ciortea SM, Crivii C, Berindan-Neagoe I. Hypoxia: overview on hypoxia-mediated mechanisms with a focus on the role of HIF genes. Int J Mol Sci. 2019;20(24):6140. (PMID: 10.3390/ijms20246140318175136941045) ; Semenza GL. Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Trends Pharmacol Sci. 2012;33(4):207–14. (PMID: 10.1016/j.tips.2012.01.005223981463437546) ; Sehouli J, Grabowski J. Surgery in recurrent ovarian cancer. Cancer. 2018;125(24):4598–601. ; Eisenhauer EA. 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(PMID: 10.1371/journal.pone.0171036281520065289508) Contributed Indexing: Keywords: Apoptosis; Ovarian cancer; Proliferation; ZHX2 Substance Nomenclature: 0 (Homeodomain Proteins) ; 0 (Transcription Factors) ; 0 (ZHX2 protein, human) Entry Date(s): Date Created: 20230206 Date Completed: 20230614 Latest Revision: 20230614 Update Code: 20231215

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Zinc fingers and homeoboxes 2 inhibition could suppress the proliferation of ovarian cancer cells by apoptosis pathway.