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Pulmonary hypertension (PH), an increase in pulmonary arterial pressure (PAP), may occur in dogs affected with myxomatous mitral valve disease (MMVD). Recent studies suggest that an accumulation of perivascular inflammatory cells may be involved with medial thickening which is a sign of the pulmonary artery remodelling in PH. The aim of this study was to characterise perivascular inflammatory cells in the surrounding pulmonary arteries of dogs with PH due to MMVD compared to MMVD dogs and healthy control dogs. Nineteen lung samples were collected from cadavers of small-breed dogs (control n = 5; MMVD n = 7; MMVD + PH n = 7). Toluidine blue stain and multiple IHC targeting α-SMA, vWF, CD20, CD68 and CD3 was performed to examine intimal and medial thickening, assess muscularisation of the small pulmonary arteries and characterise perivascular leucocytes. Medial thickening without intimal thickening of pulmonary arteries and muscularisation of normally non-muscularised small pulmonary arteries was observed in the MMVD and MMVD + PH groups compared with the control group. The perivascular numbers of B lymphocytes, T lymphocytes and macrophages was significantly increased in the MMVD + PH group compared with the MMVD and control groups. In contrast, the perivascular number of mast cells was significantly higher in the MMVD group compared with the MMVD + PH and control groups. This study suggested that pulmonary artery remodelling as medial thickening and muscularisation of the normally non-muscular small pulmonary arteries is accompanied by the accumulation of perivascular inflammatory cells.

Titel:	Perivascular inflammatory cells and their association with pulmonary arterial remodelling in dogs with pulmonary hypertension due to myxomatous mitral valve disease.
Autor/in / Beteiligte Person:	Sakarin, S ; Rungsipipat, A ; Surachetpong, SD
Link:	View record at Springer (Volltext)
Zeitschrift:	Veterinary research communications, Jg. 47 (2023-09-01), Heft 3, S. 1505-1521
Veröffentlichung:	[Cham] : Springer ; <i>Original Publication</i>: [Amsterdam] : Elsevier, 1980-, 2023
Medientyp:	academicJournal
ISSN:	1573-7446 (electronic)
DOI:	10.1007/s11259-023-10106-0
Schlagwort:	Dogs Animals Mitral Valve Vascular Remodeling Lung Hypertension, Pulmonary veterinary Heart Valve Diseases veterinary Dog Diseases diagnosis
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Vet Res Commun] 2023 Sep; Vol. 47 (3), pp. 1505-1521. <i>Date of Electronic Publication: </i>2023 Mar 28. MeSH Terms: Hypertension, Pulmonary* / veterinary ; Heart Valve Diseases* / veterinary ; Dog Diseases* / diagnosis ; Dogs ; Animals ; Mitral Valve ; Vascular Remodeling ; Lung References: Abid S, Marcos E, Parpaleix A, Amsellem V, Breau M, Houssaini A, Vienney N, Lefevre M, Derumeaux G, Evans S, Hubeau C, Delcroix M, Quarck R, Adnot S, Lipskaia L (2019) CCR2/CCR5-mediated macrophage-smoothmuscle cell crosstalk in pulmonary hypertension. Eur Respir J 54:1802308. (PMID: 31320454) ; IA Akers M Parsons MR Hill MD Hollenberg S Sanjar GJ Laurent 2000 Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2 Am J Physiol Lung Cell Mol Physiol 278 L193 201. (PMID: 10645907) ; V Amsellem S Abid L Poupel A Parpaleix M Rodero G Gary-Bobo 2017 Roles for the CX3CL1/CX3CR1 and CCL2/CCR2 Chemokine Systems in Hypoxic Pulmonary Hypertension Am J Respir Cell Mol Biol 56 597 608. (PMID: 28125278) ; L Bacakova M Travnickova E Filova R Matějka J Stepanovska J Musilkova 2018 The role of vascular smooth muscle cells in the physiology and pathophysiology of blood vessels K Sakuma Eds Muscle Cell and Tissue Current Status of Research Field IntechOpen UK 229 257. ; Y Bai HM Wang M Liu Y Wang GC Lian XH Zhang 2014 4-Chloro-DL-phenylalanine protects against monocrotaline-induced pulmonary vascular remodeling and lung inflammation Int J Mol Med 33 373 382. (PMID: 24337018) ; A Baňasová H Maxová V Hampl M Vízek V Povýšilová J Novotná 2008 Prevention of Mast Cell Degranulation by Disodium Cromoglycate Attenuates the Development of Hypoxic Pulmonary Hypertension in Rats Exposed to Chronic Hypoxia Respiration 76 102 107. (PMID: 18349522) ; B Bartelds RLE Loon Van S Mohaupt H Wijnberg MG Dickinson B Boersma 2012 Mast cell inhibition improves pulmonary vascular remodeling in pulmonary hypertension Chest 141 651 660. (PMID: 21940767) ; MO Becker A Kill M Kutsche J Guenther A Rose C Tabeling 2014 Vascular receptor autoantibodies in pulmonary arterial hypertension associated with systemic sclerosis Am J Respir Crit Care Med 190 808 817. (PMID: 25181620) ; M Borgarelli J Abbott L Braz-Ruivo D Chiavegato S Crosara K Lamb 2015 Prevalence and prognostic importance of pulmonary hypertension in dogs with myxomatous mitral valve disease J Vet Intern Med 29 569 574. (PMID: 258182104895522) ; M Borgarelli E Zini G D'agnolo A Tarducci RA Santilli D Chiavegato 2004 Comparison of primary mitral valve disease in German Shepherd dogs and in small breeds J Vet Cardiol 6 27 34. (PMID: 19083307) ; S Breitling Z Hui D Zabini Y Hu J Hoffmann NM Goldenberg 2017 The mast cell-B cell axis in lung vascular remodeling and pulmonary hypertension Am J Physiol Lung Cell Mol Physiol 312 L710 l721. (PMID: 28235950) ; S Bulfone-Paus R Bahri 2015 Mast Cells as Regulators of T Cell Responses Front Immunol 6 394. (PMID: 263008824528181) ; G Bussone MC Tamby C Calzas N Kherbeck Y Sahbatou C Sanson 2012 IgG from patients with pulmonary arterial hypertension and/or systemic sclerosis binds to vascular smooth muscle cells and induces cell contraction Ann Rheum Dis 71 596 605. (PMID: 22084393) ; E Caglayan M Trappiel A Behringer EM Berghausen M Odenthal E Wellnhofer 2019 Pulmonary arterial remodelling by deficiency of peroxisome proliferator-activated receptor-γ in murine vascular smooth muscle cells occurs independently of obesity-related pulmonary hypertension Respir Res 20 42. (PMID: 308139296391752) ; JL Caswell, KJ Williams (2016) Respiratory System. In: Maxie MG, Saunders WB (eds) Jubb, Kennedy and Palmer's Pathology of Domestic Animals: Volume 2, 6th edn. pp 465–591. ; JP Chandler TJ Yang 1981 Identification of canine lymphocyte populations by immunofluorescence surface marker analysis Int Arch Allergy Appl Immunol 65 62 68. (PMID: 7012041) ; I Chazova I Robbins J Loyd J Newman V Tapson V Zhdaov 2000 Venous and arterial changes in pulmonary veno-occlusive disease, mitral stenosis and fibrosing mediastinitis Eur Respir J 15 116 122. (PMID: 10678631) ; S Chen D Yan A Qiu 2020 The role of macrophages in pulmonary hypertension: Pathogenesis and targeting Int Immunopharmacol 88 106934. (PMID: 32889242) ; D Chiavegato M Borgarelli G D'agnolo RA Santilli 2009 Pulmonary hypertension in dogs with mitral regurgitation attributable to myxomatous valve disease Vet Radiol Ultrasound 50 253 258. (PMID: 19507386) ; P Clark DE Normansell DJ Innes CE Hess 1986 Lymphocyte Subsets in Normal Bone Marrow Blood 67 1600 1606. (PMID: 3486683) ; KL Colvin PJ Cripe DD Ivy KR Stenmark ME Yeager 2013 Bronchus-associated lymphoid tissue in pulmonary hypertension produces pathologic autoantibodies Am J Respir Crit Care Med 188 1126 1136. (PMID: 240936383863738) ; MJ Cuttica T Langenickel A Noguchi RF Machado MT Gladwin M Boehm 2011 Perivascular T-cell infiltration leads to sustained pulmonary artery remodeling after endothelial cell damage Am J Respir Cell Mol Biol 45 62 71. (PMID: 20813993) ; BK Dahal D Kosanovic C Kaulen T Cornitescu R Savai J Hoffmann 2011 Involvement of mast cells in monocrotaline-induced pulmonary hypertension in rats Respir Res 12 60. (PMID: 215358813104382) ; JF Delgado E Conde V Sanchez F Lopez-Rios MA Gomez-Sanchez P Escribano 2005 Pulmonary vascular remodeling in pulmonary hypertension due to chronic heart failure Eur J Heart Fail 7 1011 1016. (PMID: 16227139) ; S Disatian EJ Ehrhart S Zimmerman EC Orton 2008 Interstitial cells from dogs with naturally occurring myxomatous mitral valve disease undergo phenotype transformation J Heart Valve Dis 17 402 411. (PMID: 18751470) ; S Disatian C Lacerda EC Orton 2010 Tryptophan hydroxylase 1 expression is increased in phenotype-altered canine and human degenerative myxomatous mitral valves J Heart Valve Dis 19 71 78. (PMID: 20329492) ; P Dorfmüller F Perros K Balabanian M Humbert 2003 Inflammation in pulmonary arterial hypertension Eur Respir J 22 358 363. (PMID: 12952274) ; J Florentin E Coppin SB Vasamsetti J Zhao YY Tai Y Tang 2018 Inflammatory Macrophage Expansion in Pulmonary Hypertension Depends upon Mobilization of Blood-Borne Monocytes J Immunol 200 3612 3625. (PMID: 29632145) ; MG Frid JA Brunetti DL Burke TC Carpenter NJ Davie JT Reeves 2006 Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage Am J Pathol 168 659 669. (PMID: 164366791606508) ; MG Frid BA Mckeon JM Thurman BA Maron M Li H Zhang 2020 Immunoglobulin-driven Complement Activation Regulates Proinflammatory Remodeling in Pulmonary Hypertension Am J Respir Crit Care Med 201 224 239. (PMID: 315456486961733) ; C Gerges M Gerges MB Lang Y Zhang J Jakowitsch P Probst 2013 Diastolic pulmonary vascular pressure gradient: a predictor of prognosis in "out-of-proportion" pulmonary hypertension Chest 143 758 766. (PMID: 23580984) ; M-R Ghigna P Dorfmüller 2019 Pulmonary vascular disease and pulmonary hypertension Diagn Histopathol 25 304 312. ; M Guazzi N Galiè 2012 Pulmonary hypertension in left heart disease Eur Respir Rev 21 338 346. (PMID: 232041229487233) ; C Guglielmini C Civitella A Diana M Tommaso Di M Cipone A Luciani 2010 Serum cardiac troponin I concentration in dogs with precapillary and postcapillary pulmonary hypertension J Vet Intern Med 24 145 152. (PMID: 20002552) ; C Guignabert P Dorfmuller 2013 Pathology and pathobiology of pulmonary hypertension Semin Respir Crit Care Med 34 551 559. (PMID: 24037624) ; J Hoffmann J Yin M Kukucka N Yin I Saarikko A Sterner-Kock 2011 Mast cells promote lung vascular remodelling in pulmonary hypertension Eur Respir J 37 1400 1410. (PMID: 21148228) ; Y Hu L Chi WM Kuebler NM Goldenberg 2020 Perivascular Inflammation in Pulmonary Arterial Hypertension Cells 9 2338. (PMID: 331055887690279) ; M Humbert C Guignabert S Bonnet P Dorfmüller JR Klinger MR Nicolls 2019 Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives Eur Respir J 53 1801887. (PMID: 305459706351340) ; JM Hunt B Bethea X Liu A Gandjeva PPA Mammen E Stacher 2013 Pulmonary veins in the normal lung and pulmonary hypertension due to left heart disease Am J Physiol Lung Cell Mol Physiol 305 L725 L736. (PMID: 240392553840271) ; R Jennings C Premanandan 2017 Veterinary Histology Ohio State University Libraries. ; BW Keene CE Atkins JD Bonagura PR Fox J Häggström VL Fuentes 2019 ACVIM consensus guidelines for the diagnosis and treatment of myxomatous mitral valve disease in dogs J Vet Intern Med 33 1127 1140. (PMID: 309740156524084) ; HB Kellihan RL Stepien 2010 Pulmonary hypertension in dogs: diagnosis and therapy Vet Clin North Am Small Anim Pract 40 623 641. (PMID: 20610015) ; HB Kellihan RL Stepien 2012 Pulmonary hypertension in canine degenerative mitral valve disease J Vet Cardiol 14 149 164. (PMID: 22364721) ; WM Kuebler S Bonnet A Tabuchi 2018 Inflammation and autoimmunity in pulmonary hypertension: is there a role for endothelial adhesion molecules? (2017 Grover Conference Series) Pulm Circ 8 2045893218757596 2045893218757596. (PMID: 294801345865459) ; K Kurakula VFED Smolders O Tura-Ceide JW Jukema PHA Quax M-J Goumans 2021 Endothelial Dysfunction in Pulmonary Hypertension: Cause or Consequence? Biomedicines 9 57. (PMID: 334353117827874) ; G Kwapiszewska P Markart BK Dahal B Kojonazarov LM Marsh RT Schermuly 2012 PAR-2 Inhibition Reverses Experimental Pulmonary Hypertension Circ Res 110 1179 1191. (PMID: 22461388) ; M Lévy C Maurey DS Celermajer PR Vouhé C Danel D Bonnet 2007 Impaired Apoptosis of Pulmonary Endothelial Cells Is Associated With Intimal Proliferation and Irreversibility of Pulmonary Hypertension in Congenital Heart Disease J Am Coll Cardiol 49 803 810. (PMID: 17306711) ; C Li J Feng L Cai Li M Yan W Ying Wei F Jing 2016 Muscularization of Pulmonary Artery and RhoA/ROCK levels in Rats Exposed to Intermittent Hypoxia Int J Clin Exp Pathol 9 10139 10148. ; M Li SR Riddle MG Frid KC Kasmi El TA Mckinsey RJ Sokol 2011 Emergence of fibroblasts with a proinflammatory epigenetically altered phenotype in severe hypoxic pulmonary hypertension J Immunol 187 2711 2722. (PMID: 21813768) ; M Liu Y Wang HM Wang Y Bai XH Zhang YX Sun 2013 Fluoxetine attenuates chronic methamphetamine-induced pulmonary arterial remodelling: possible involvement of serotonin transporter and serotonin 1B receptor Basic Clin Pharmacol Toxicol 112 77 82. (PMID: 22900600) ; R Mathew R (2020) Endothelial Dysfunction and Disruption in Pulmonary Hypertension. In: Abukabda A, Suciu M, Andor MM (eds) Cardiovascular Risk Factors in Pathology. IntechOpen, pp 92177. ; H Maxová M Vasilková J Novotná O Vajnerová A Bansová M Vízek 2010 Prevention of mast cell degranulation by disodium cromoglycate delayed the regression of hypoxic pulmonary hypertension in rats Respiration 80 335 339. (PMID: 20389049) ; C Medrek F Pontén K Jirström K Leandersson 2012 The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients BMC Cancer 12 306. (PMID: 228240403414782) ; D Montani F Perros N Gambaryan B Girerd P Dorfmuller LC Price 2011 C-kit-positive cells accumulate in remodeled vessels of idiopathic pulmonary arterial hypertension Am J Respir Crit Care Med 184 116 123. (PMID: 21471108) ; DL Moraes WS Colucci MM Givertz 2000 Secondary pulmonary hypertension in chronic heart failure: the role of the endothelium in pathophysiology and management Circulation 102 1718 1723. (PMID: 11015353) ; M Muñoz-Esquerre M López-Sánchez I Escobar D Huertas R Penín M Molina-Molina 2016 Systemic and pulmonary vascular remodelling in chronic obstructive pulmonary disease PLOS ONE 11 e0152987. (PMID: 270462034821623) ; H Patel M Desai EM Tuzcu B Griffin S Kapadia 2014 Pulmonary hypertension in mitral regurgitation J Am Heart Assoc 3 e000748. (PMID: 251032024310359) ; F Perros P Dorfmüller D Montani H Hammad W Waelput B Girerd 2012 Pulmonary lymphoid neogenesis in idiopathic pulmonary arterial hypertension Am J Respir Crit Care Med 185 311 321. (PMID: 22108206) ; RF Pinto L Higuchi Mde VD Aiello 2004 Decreased numbers of T-lymphocytes and predominance of recently recruited macrophages in the walls of peripheral pulmonary arteries from 26 patients with pulmonary hypertension secondary to congenital cardiac shunts Cardiovasc Pathol 13 268 275. (PMID: 15358341) ; LC Price SJ Wort F Perros P Dorfmüller A Huertas D Montani 2012 Inflammation in pulmonary arterial hypertension Chest 141 210 221. (PMID: 22215829) ; SC Pugliese S Kumar WJ Janssen BB Graham MG Frid SR Riddle 2017 A Time- and Compartment-Specific Activation of Lung Macrophages in Hypoxic Pulmonary Hypertension J Immunol 198 4802 4812. (PMID: 28500078) ; TR Quinlan D Li VE Laubach EG Shesely N Zhou RA Johns 2000 eNOS-deficient mice show reduced pulmonary vascular proliferation and remodeling to chronic hypoxia Am J Physiol Lung Cell Mol Physiol 279 L641 650. (PMID: 11000123) ; M Rabinovitch C Guignabert M Humbert MR Nicolls 2014 Inflammation and immunity in the pathogenesis of pulmonary arterial hypertension Circ Res 115 165 175. (PMID: 249517654097142) ; B Ranchoux LD Harvey RJ Ayon A Babicheva S Bonnet SY Chan 2018 Endothelial dysfunction in pulmonary arterial hypertension: an evolving landscape (2017 Grover Conference Series) Pulm Circ 8 2045893217752912. (PMID: 29283043) ; C Reinero LC Visser HB Kellihan I Masseau E Rozanski C Clercx 2020 ACVIM consensus statement guidelines for the diagnosis, classification, treatment, and monitoring of pulmonary hypertension in dogs J Vet Intern Med 34 549 573. (PMID: 320654287097566) ; S Sakarin A Rungsipipat SD Surachetpong 2021 Histopathological changes of pulmonary vascular remodeling in dogs affected with pulmonary hypertension secondary to degenerative mitral valve disease J Vet Cardiol 36 141 152. (PMID: 34284267) ; R Savai SS Pullamsetti J Kolbe E Bieniek R Voswinckel L Fink 2012 Immune and inflammatory cell involvement in the pathology of idiopathic pulmonary arterial hypertension Am J Respir Crit Care Med 186 897 908. (PMID: 22955318) ; RT Schermuly KP Kreisselmeier HA Ghofrani A Samidurai S Pullamsetti N Weissmann 2004 Antiremodeling effects of iloprost and the dual-selective phosphodiesterase 3/4 inhibitor tolafentrine in chronic experimental pulmonary hypertension Circ Res 94 1101 1108. (PMID: 15031263) ; KE Schober TM Hart JA Stern X Li VF Samii LJ Zekas 2010 Detection of congestive heart failure in dogs by Doppler echocardiography J Vet Intern Med 24 1358 1368. (PMID: 20840304) ; FJ Serres V Chetboul R Tissier C Carlos Sampedrano V Gouni AP Nicolle 2006 Doppler echocardiography-derived evidence of pulmonary arterial hypertension in dogs with degenerative mitral valve disease: 86 cases (2001–2005) J Am Vet Med Assoc 229 1772 1778. (PMID: 17144824) ; Y Song L Coleman J Shi H Beppu K Sato K Walsh 2008 Inflammation, endothelial injury, and persistent pulmonary hypertension in heterozygous BMPR2-mutant mice Am J Physiol Heart Circ Physiol 295 H677 690. (PMID: 185521562519229) ; S Standring 2020 Gray's Anatomy: The Anatomical Basis of Clinical Practice Elsevier. ; L Taraseviciene-Stewart MR Nicolls D Kraskauskas R Scerbavicius N Burns C Cool 2007 Absence of T cells confers increased pulmonary arterial hypertension and vascular remodeling Am J Respir Crit Care Med 175 1280 1289. (PMID: 174131272176089) ; MI Townsley 2012 Structure and composition of pulmonary arteries, capillaries, and veins Compr Physiol 2 675 709. (PMID: 236069293630377) ; E Vergadi MS Chang C Lee OD Liang X Liu A Fernandez-Gonzalez 2011 Early macrophage recruitment and alternative activation are critical for the later development of hypoxia-induced pulmonary hypertension Circulation 123 1986 1995. (PMID: 215189863125055) ; HL Wang LP Peng WJ Chen SH Tang BZ Sun CL Wang 2014 HMGB1 enhances smooth muscle cell proliferation and migration in pulmonary artery remodeling Int J Clin Exp Pathol 7 3836 3844. (PMID: 251207604128995) ; PS Yang DH Kim YJ Lee SE Lee WJ Kang HJ Chang 2014 Glycyrrhizin, inhibitor of high mobility group box-1, attenuates monocrotaline-induced pulmonary hypertension and vascular remodeling in rats Respir Res 15 148. (PMID: 254209244248446) ; IN Zelko J Zhu JD Ritzenthaler J Roman 2016 Pulmonary hypertension and vascular remodeling in mice exposed to crystalline silica Respir Res 17 160. (PMID: 278942975126840) ; FG Zhai XH Zhang HL Wang 2009 Fluoxetine protects against monocrotaline-induced pulmonary arterial hypertension: potential roles of induction of apoptosis and upregulation of Kv1.5 channels in rats Clin Exp Pharmacol Physiol 36 850 856. (PMID: 19298536) Contributed Indexing: Keywords: Inflammatory cells; Medial thickening; Myxomatous mitral valve disease; Pulmonary artery; Pulmonary hypertension Entry Date(s): Date Created: 20230328 Date Completed: 20230908 Latest Revision: 20230922 Update Code: 20240513

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Perivascular inflammatory cells and their association with pulmonary arterial remodelling in dogs with pulmonary hypertension due to myxomatous mitral valve disease.