Einzeltreffer — DigiBib

Background: Approximately one-third of long coronavirus disease 2019 (long COVID) patients report breathlessness and fatigue even during activities of daily living. We hypothesised that abnormalities of combined diffusing capacity of the lung for nitric oxide ( D LNO ) and carbon monoxide ( D LCO ) at rest or after mild exercise are associated with breathlessness in patients with long COVID.

Methods: Single-breath combined D LNO and D LCO were measured at rest and immediately after a short bout of treadmill exercise simulating ordinary walking in 32 Caucasian patients with long COVID and dyspnoea at rest. 20 subjects served as a control group.

Results: At rest, combined D LNO , D LCO and alveolar volume ( V A ) were significantly lower in long COVID than in controls, with D LNO and D LCO being below the limits of normal in 69% and 41% of cases, respectively. Mean values of D LNO / V A and D LCO / V A in long COVID patients were less than controls, yet, in only 22% and 12% of long COVID patients were the values of D LNO / V A and D LCO / V A below the limits of normal. After treadmill exercise, D LNO , D LNO / D LCO , V A and heart rate increased significantly without differences between groups. D LNO remained below the limit of normal in 47% of long COVID patients.

Conclusion: These data suggest localised discrete loss of lung units in approximately half of long COVID patients, not completely explained by loss of V A or of alveolar-capillary recruitment during exercise.

Competing Interests: Conflict of interest: The authors have nothing to disclose.

Titel:	Lung diffusing capacities for nitric oxide and carbon monoxide at rest and post-walking in long COVID.
Autor/in / Beteiligte Person:	Barisione, G ; Brusasco, V
Link:	Full Text Finder (Volltext)
Zeitschrift:	ERJ open research, Jg. 9 (2023-04-17), Heft 2
Veröffentlichung:	Sheffield : European Respiratory Society, [2015]-, 2023
Medientyp:	academicJournal
ISSN:	2312-0541 (print)
DOI:	10.1183/23120541.00363-2022
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [ERJ Open Res] 2023 Apr 17; Vol. 9 (2). <i>Date of Electronic Publication: </i>2023 Apr 17 (<i>Print Publication: </i>2023). Comments: Comment in: ERJ Open Res. 2023 Apr 17;9(2):. (PMID: 37077548) References: Eur Respir J. 2005 Sep;26(3):511-22. (PMID: 16135736) ; Sci Rep. 2022 May 25;12(1):8801. (PMID: 35614108) ; Chest. 2002 Nov;122(5):1774-83. (PMID: 12426283) ; Chest. 1994 Feb;105(2):501-8. (PMID: 8306754) ; J Appl Physiol Respir Environ Exerc Physiol. 1984 Dec;57(6):1773-82. (PMID: 6511552) ; Clin Infect Dis. 2021 Sep 7;73(5):e1089-e1098. (PMID: 33220049) ; Eur Respir J. 2017 Sep 11;50(3):. (PMID: 28893868) ; Eur J Appl Physiol. 2004 Oct;93(1-2):96-101. (PMID: 15278353) ; Respir Med. 2007 Jul;101(7):1579-84. (PMID: 17229562) ; Eur Respir J. 2012 Dec;40(6):1324-43. (PMID: 22743675) ; Neuroimage. 2006 Jul 1;31(3):1116-28. (PMID: 16545965) ; Am J Respir Crit Care Med. 2019 Oct 15;200(8):e70-e88. (PMID: 31613151) ; Eur Respir J. 2017 Feb 8;49(2):. (PMID: 28179436) ; J Am Soc Echocardiogr. 2021 Dec;34(12):1273-1284.e9. (PMID: 34508837) ; J Cachexia Sarcopenia Muscle. 2021 Aug;12(4):1056-1063. (PMID: 34102017) ; J Appl Physiol. 1969 Dec;27(6):826-33. (PMID: 4901006) ; Phys Ther. 2021 Jun 1;101(6):. (PMID: 33735374) ; ERJ Open Res. 2021 Aug 23;7(3):. (PMID: 34435029) ; Eur Respir J. 2021 Mar 11;57(3):. (PMID: 33707167) ; J Appl Physiol (1985). 2021 May 1;130(5):1470-1478. (PMID: 33764166) ; Lancet. 2021 Jan 16;397(10270):220-232. (PMID: 33428867) ; J Appl Physiol (1985). 2003 Apr;94(4):1634-40. (PMID: 12626477) ; Eur Respir J. 1990 Mar;3(3):323-8. (PMID: 2340891) ; J Appl Physiol (1985). 2017 Jun 1;122(6):1425-1434. (PMID: 28336536) ; Respir Physiol Neurobiol. 2016 May;225:48-59. (PMID: 26851654) ; Eur Respir J. 2013 Feb;41(2):453-61. (PMID: 22936707) ; Compr Physiol. 2019 Dec 18;10(1):73-97. (PMID: 31853952) ; Chest. 2001 Dec;120(6):1850-6. (PMID: 11742912) ; Clin Sci. 1972 Mar;42(3):325-35. (PMID: 5013875) ; Eur Respir J. 2021 Aug 26;58(2):. (PMID: 34210791) ; Eur Respir J. 1995 Mar;8(3):492-506. (PMID: 7789503) ; Eur Respir J. 2017 Jan 3;49(1):. (PMID: 28049168) ; Physiol Rep. 2019 Aug;7(13):e14149. (PMID: 31264386) ; Eur Respir J. 2021 Aug 26;58(2):. (PMID: 34385265) ; Eur Respir J. 2018 Jul 19;52(1):. (PMID: 29903858) ; Physiol Rep. 2021 Feb;9(4):e14748. (PMID: 33625799) ; J Am Coll Cardiol. 2001 Jan;37(1):153-6. (PMID: 11153730) ; Am J Respir Crit Care Med. 2012 Jul 15;186(2):132-9. (PMID: 22538804) ; Chest. 2006 Sep;130(3):827-33. (PMID: 16963682) ; J Appl Physiol (1985). 2022 Mar 1;132(3):581-592. (PMID: 35019775) ; Am J Respir Crit Care Med. 2004 May 1;169(9):1034-40. (PMID: 14977623) ; Eur Respir J. 2020 Jun 18;55(6):. (PMID: 32381497) Entry Date(s): Date Created: 20230418 Latest Revision: 20230420 Update Code: 20231215 PubMed Central ID: PMC9638122

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Lung diffusing capacities for nitric oxide and carbon monoxide at rest and post-walking in long COVID.