Clinical Characterization of HCC/CCA Mixed Cancers in a Population-based Cohort.

Teufel, A ; Rodriguez, I ; et al.

In: Journal of gastrointestinal and liver diseases : JGLD, Jg. 32 (2023-06-22), Heft 2, S. 190-196

Online academicJournal

Zugriff:

Volltext (PDF)

Background and Aims: Primary liver cancer (PLC) ranks among of the most common cancers worldwide. Within this group, a minority of cases displays characteristics of both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA), known as combined hepatocellular cholangiocarcinoma (cHCC- CCA). Currently, there is no specific standardized therapy for these mixed tumors. Therefore, the aim of our study was to analyze the clinical course, treatment and outcome of cHCC-CCA patients in a European population-based registry.

Methods: We investigated 9,144 patients with PLC (6,622 HCC, 2,356 iCCA, and 166 cHCC-CCA) diagnosed between 2009 and 2020. All data were obtained from Clinical Cancer Registry of Baden-Württemberg (BW), Germany.

Results: In all three groups patients were predominantly male (82%, 57%, and 68% for HCC, iCCA and cHCC-CCA groups, respectively). 48% of cHCC-CCA patients were diagnosed as stage IV cancers, which was more than for HCC (31%) but less compared to CCA (64%). Overall median survival of cHCC-CCA patients was worse compared to HCC (9-13 months vs. 15.5 months, p<0.001) and rather comparable to CCA (11.8 months).

Conclusions: Our data demonstrated that cHCC-CCA tumors appear to have a distinct clinical course with worse overall survival compared to HCC. Thus, identification of these cancers by histopathology is essential in order to further characterize this tumor entity and to provide accurate treatment to these patients.

Titel:	Clinical Characterization of HCC/CCA Mixed Cancers in a Population-based Cohort.
Autor/in / Beteiligte Person:	Teufel, A ; Rodriguez, I ; Winzler, C ; Kokh, D ; Ebert, MP ; Surovtsova, I ; Morakis, P
Link:	Volltext (PDF)
Zeitschrift:	Journal of gastrointestinal and liver diseases : JGLD, Jg. 32 (2023-06-22), Heft 2, S. 190-196
Veröffentlichung:	Cluj-Napoca, Romania : Editura Medicală Universitară "Iuliu Haţieganu", c2006-, 2023
Medientyp:	academicJournal
ISSN:	1842-1121 (electronic)
DOI:	10.15403/jgld-4893
Schlagwort:	Humans Male Female Bile Ducts, Intrahepatic pathology Disease Progression Retrospective Studies Carcinoma, Hepatocellular epidemiology Carcinoma, Hepatocellular therapy Carcinoma, Hepatocellular diagnosis Liver Neoplasms epidemiology Liver Neoplasms therapy Liver Neoplasms diagnosis Cholangiocarcinoma epidemiology Cholangiocarcinoma therapy Cholangiocarcinoma diagnosis Bile Duct Neoplasms epidemiology Bile Duct Neoplasms therapy Bile Duct Neoplasms diagnosis
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [J Gastrointestin Liver Dis] 2023 Jun 22; Vol. 32 (2), pp. 190-196. <i>Date of Electronic Publication: </i>2023 Jun 22. MeSH Terms: Carcinoma, Hepatocellular* / epidemiology ; Carcinoma, Hepatocellular* / therapy ; Carcinoma, Hepatocellular* / diagnosis ; Liver Neoplasms* / epidemiology ; Liver Neoplasms* / therapy ; Liver Neoplasms* / diagnosis ; Cholangiocarcinoma* / epidemiology ; Cholangiocarcinoma* / therapy ; Cholangiocarcinoma* / diagnosis ; Bile Duct Neoplasms* / epidemiology ; Bile Duct Neoplasms* / therapy ; Bile Duct Neoplasms* / diagnosis ; Humans ; Male ; Female ; Bile Ducts, Intrahepatic / pathology ; Disease Progression ; Retrospective Studies Entry Date(s): Date Created: 20230622 Date Completed: 20230623 Latest Revision: 20230625 Update Code: 20240514

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.