Causal associations between dietary habits and CVD: a Mendelian randomisation study.
In: The British journal of nutrition, Jg. 130 (2023-12-28), Heft 12, S. 2104-2113
Online
academicJournal
Zugriff:
Over the years, numerous observational studies have substantiated that various dietary choices have opposing effects on CVD. However, the causal effect has not yet been established. Thus, we conducted a Mendelian randomisation (MR) analysis to reveal the causal impact of dietary habits on CVD. Genetic variants strongly associated with 20 dietary habits were selected from publicly available genome-wide association studies conducted on the UK Biobank cohort ( n 449 210). Summary-level data on CVD were obtained from different consortia ( n 159 836-977 323). The inverse-variance weighted method (IVW) was the primary outcome, while MR-Egger, weighted median and MR Pleiotropy RESidual Sum and Outlier were used to assess heterogeneity and pleiotropy. We found compelling evidence of a protective causal effect of genetic predisposition towards cheese consumption on myocardial infarction (IVW OR = 0·67; 95 % CI = 0·544, 0·826; P = 1·784 × 10 -4 ) and heart failure (IVW OR = 0·646; 95 % CI = 0·513, 0·814; P = 2·135 × 10 -4 ). Poultry intake was found to be a detrimental factor for hypertension (IVW OR = 4·306; 95 % CI = 2·158, 8·589; P = 3·416 × 10 -5 ), while dried fruit intake was protective against hypertension (IVW OR = 0·473; 95 % CI = 0·348, 0·642; P = 1·683 × 10 -6 ). Importantly, no evidence of pleiotropy was detected. MR estimates provide robust evidence for a causal relationship between genetic predisposition to 20 dietary habits and CVD risk, suggesting that well-planned diets may help prevent and reduce the risk of CVD.
Titel: |
Causal associations between dietary habits and CVD: a Mendelian randomisation study.
|
---|---|
Autor/in / Beteiligte Person: | Yang, M ; Gao, X ; Xie, L ; Lin, Z ; Ye, X ; Ou, J ; Peng, J |
Link: | |
Zeitschrift: | The British journal of nutrition, Jg. 130 (2023-12-28), Heft 12, S. 2104-2113 |
Veröffentlichung: | <2000->: Wallingford, Oxon, UK : Published on behalf of the Nutrition Society by CABI Publishing ; <i>Original Publication</i>: [Cambridge, New York] Cambridge University Press., 2023 |
Medientyp: | academicJournal |
ISSN: | 1475-2662 (electronic) |
DOI: | 10.1017/S000711452300140X |
Schlagwort: |
|
Sonstiges: |
|