A Multichannel Portable Platform With Embedded Thermal Management for Miniaturized Dielectric Blood Coagulometry.
In: IEEE transactions on biomedical circuits and systems, Jg. 17 (2023-08-01), Heft 4, S. 843-856
Online
academicJournal
Zugriff:
This article presents a standalone, multichannel, miniaturized impedance analyzer (MIA) system for dielectric blood coagulometry measurements with a microfluidic sensor termed ClotChip. The system incorporates a front-end interface board for 4-channel impedance measurements at an excitation frequency of 1 MHz, an integrated resistive heater formed by a pair of printed-circuit board (PCB) traces to keep the blood sample near a physiologic temperature of 37 °C, a software-defined instrument module for signal generation and data acquisition, and a Raspberry Pi-based embedded computer with 7-inch touchscreen display for signal processing and user interface. When measuring fixed test impedances across all four channels, the MIA system exhibits an excellent agreement with a benchtop impedance analyzer, with rms errors of ≤0.30% over a capacitance range of 47-330 pF and ≤0.35% over a conductance range of 2.13-10 mS. Using in vitro-modified human whole blood samples, the two ClotChip output parameters, namely, the time to reach a permittivity peak (T peak ) and maximum change in permittivity after the peak (Δϵ r,max ) are assessed by the MIA system and benchmarked against the corresponding parameters of a rotational thromboelastometry (ROTEM) assay. T peak exhibits a very strong positive correlation (r = 0.98, p < 10 -6 , n = 20) with the ROTEM clotting time (CT) parameter, while Δϵ r,max exhibits a very strong positive correlation (r = 0.92, p < 10 -6 , n = 20) with the ROTEM maximum clot firmness (MCF) parameter. This work shows the potential of the MIA system as a standalone, multichannel, portable platform for comprehensive assessment of hemostasis at the point-of-care/point-of-injury (POC/POI).
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A Multichannel Portable Platform With Embedded Thermal Management for Miniaturized Dielectric Blood Coagulometry.
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Autor/in / Beteiligte Person: | Delianides, CA ; Pourang, S ; Hernandez, S ; Disharoon, D ; Ahuja, SP ; Neal, MD ; Gupta, AS ; Mohseni, P ; Suster, MA |
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Zeitschrift: | IEEE transactions on biomedical circuits and systems, Jg. 17 (2023-08-01), Heft 4, S. 843-856 |
Veröffentlichung: | New York, NY : IEEE, c2007-, 2023 |
Medientyp: | academicJournal |
ISSN: | 1940-9990 (electronic) |
DOI: | 10.1109/TBCAS.2023.3291875 |
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