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The emergence and reemergence of mosquito-borne diseases in Brazil such as yellow fever, zika, chikungunya, and dengue have had serious impacts on public health. Concerns have been raised due to the rapid dissemination of the chikungunya virus across the country since its first detection in 2014 in Northeast Brazil. In this work, we carried out on-site training activities in genomic surveillance in partnership with the National Network of Public Health Laboratories that have led to the generation of 422 chikungunya virus genomes from 12 Brazilian states over the past two years (2021-2022), a period that has seen more than 312 thousand chikungunya fever cases reported in the country. These genomes increased the amount of available data and allowed a more comprehensive characterization of the dispersal dynamics of the chikungunya virus East-Central-South-African lineage in Brazil. Tree branching patterns revealed the emergence and expansion of two distinct subclades. Phylogeographic analysis indicated that the northeast region has been the leading hub of virus spread towards other regions. Increased frequency of C > T transitions among the new genomes suggested that host restriction factors from the immune system such as ADAR and AID/APOBEC deaminases might be driving the genetic diversity of the chikungunya virus in Brazil.

Titel:	Increased interregional virus exchange and nucleotide diversity outline the expansion of chikungunya virus in Brazil.
Autor/in / Beteiligte Person:	Xavier, J ; Alcantara, LCJ ; Fonseca, V ; Lima, M ; Castro, E ; Fritsch, H ; Oliveira, C ; Guimarães, N ; Adelino, T ; Evaristo, M ; Rodrigues, ES ; Santos, EV ; de La-Roque D ; de Moraes L ; Tosta, S ; Neto, A ; Rosewell, A ; Mendonça, AF ; Leite, A ; Vasconcelos, A ; Silva de Mello, AL ; Vasconcelos, B ; Montalbano, CA ; Zanluca, C ; Freitas, C ; de Albuquerque CFC ; Duarte Dos Santos, CN ; Santos, CS ; Dos Santos, CA ; Gonçalves, CCM ; Teixeira, D ; Neto, DFL ; Cabral, D ; de Oliveira EC ; Noia Maciel, EL ; Pereira, FM ; Iani, F ; de Carvalho FP ; Andrade, G ; Bezerra, G ; de Castro Lichs GG ; Pereira, GC ; Barroso, H ; Franz, HCF ; Ferreira, H ; Gomes, I ; Riediger, IN ; Rodrigues, I ; de Siqueira IC ; Silva, J ; Rico, JM ; Lima, J ; Abrantes, J ; do Nascimento JPM ; Wasserheit, JN ; Pastor, J ; de Magalhães JJF ; Luz, KG ; Lima Neto, LG ; Frutuoso, LCV ; da Silva LB ; Sena, L ; de Sousa LAF ; Pereira, LA ; Demarchi, L ; Câmara, MCB ; Astete, MG ; Almiron, M ; Umaki Zardin, MCS ; Presibella, MM ; Falcão, MB ; Gale M Jr ; Freire, N ; Marques, N ; de Moura NFO ; Almeida Da Silva, PE ; Rabinowitz, P ; da Cunha RV ; Trinta, KS ; do Carmo Said RF ; Kato, R ; Stabeli, R ; de Jesus R ; Hans Santos, R ; Kashima, S ; Slavov, SN ; Andrade, T ; Rocha, T ; Carneiro, T ; Nardy, V ; da Silva V ; Carvalho, WG ; Van Voorhis, WC ; Araujo, WN ; de Filippis AMB ; Giovanetti, M
Link:	View record at Springer (Volltext)
Zeitschrift:	Nature communications, Jg. 14 (2023-07-21), Heft 1, S. 4413
Veröffentlichung:	[London] : Nature Pub. Group, 2023
Medientyp:	academicJournal
ISSN:	2041-1723 (electronic)
DOI:	10.1038/s41467-023-40099-y
Schlagwort:	Animals Humans Brazil epidemiology Nucleotides Chikungunya virus genetics Chikungunya Fever epidemiology Yellow Fever Zika Virus Zika Virus Infection
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural Language: English [Nat Commun] 2023 Jul 21; Vol. 14 (1), pp. 4413. <i>Date of Electronic Publication: </i>2023 Jul 21. MeSH Terms: Chikungunya virus* / genetics ; Chikungunya Fever* / epidemiology ; Yellow Fever* ; Zika Virus* ; Zika Virus Infection* ; Animals ; Humans ; Brazil / epidemiology ; Nucleotides Comments: Update of: medRxiv. 2023 Apr 03;:. (PMID: 37034611) References: Virus Evol. 2018 Jun 04;4(1):vey012. (PMID: 29942653) ; BMC Infect Dis. 2019 Nov 27;19(1):1004. (PMID: 31775718) ; Mem Inst Oswaldo Cruz. 2022 Apr 22;117:e210383. (PMID: 35475905) ; PLoS Curr. 2017 Feb 14;9:. (PMID: 28286701) ; Nat Protoc. 2017 Jun;12(6):1261-1276. (PMID: 28538739) ; Emerg Infect Dis. 2008 Mar;14(3):412-5. (PMID: 18325255) ; Virology. 2016 Oct;497:59-68. (PMID: 27423270) ; Mol Biol Evol. 2012 Sep;29(9):2157-67. 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Increased interregional virus exchange and nucleotide diversity outline the expansion of chikungunya virus in Brazil.