[Effect of Plasmacytoid Dendritic Cell Dose in Grafts on CMV Infection after Allogeneic Hematopoietic Stem Cell Transplantation].
In: Zhongguo shi yan xue ye xue za zhi, Jg. 31 (2023-08-01), Heft 4, S. 1184-1191
academicJournal
Zugriff:
Objective: To investigate the correlation between plasmacytoid dendritic cell (pDC) dose in grafts and the occurrence of cytomegalovirus (CMV) infection after allogeneic hematopoietic stem cell transplantation (allo-HSCT).
Methods: The clinical data of 80 children who received allo-HSCT in Children's Hospital of Soochow University from August 20, 2020 to June 11, 2021 were retrospectively analyzed. Proportions of DC subsets and T-cell subsets in grafts were detected by flow cytometry in order to calculate infused cell dose of each cell. Weekly monitoring of CMV-DNA copies in peripheral blood for each child were performed after transplantation. The last follow-up date was December 31, 2021.
Results: All the children gained hematopoietic reconstitution. CMV infection was observed in 51 children (63.8%±5.4%) within the first 100 days after transplantation, including 2 cases developing CMV disease. Univariate analysis indicated that infused doses of DC and pDC were significantly associated with CMV infection within 100 days after allo-HSCT ( P <0.05). Multivariate analysis indicated that a high dose infusion of pDC was an independent protective factor for CMV infection within 100 days after allo-HSCT ( P <0.05). By the end of follow-up, 7 children died of transplantation-related complications, including 2 deaths from CMV disease, 2 deaths from extensive chronic graft-versus-host disease, and 3 deaths from capillary leak syndrome. The overall survival rate was 91.2%.
Conclusion: The pDC in grafts may be associated with early infection of CMV after allo-HSCT, while a high infused pDC dose may serve as a protective factor for CMV infection after transplantation.
Titel: |
[Effect of Plasmacytoid Dendritic Cell Dose in Grafts on CMV Infection after Allogeneic Hematopoietic Stem Cell Transplantation].
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Autor/in / Beteiligte Person: | Yao, D ; Tian, YY ; Lu, J ; Xiao, PF ; Ling, J ; Zheng, DF ; Gao, J ; Fan, LY ; Zheng, JJ ; Li, J ; Hu, SY |
Zeitschrift: | Zhongguo shi yan xue ye xue za zhi, Jg. 31 (2023-08-01), Heft 4, S. 1184-1191 |
Veröffentlichung: | Beijing : Zhongguo shi yan xue za zhi she,, 2023 |
Medientyp: | academicJournal |
ISSN: | 1009-2137 (print) |
DOI: | 10.19746/j.cnki.issn.1009-2137.2023.04.039 |
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