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Objective: This meta-analysis aimed to explore the association between selective serotonine reuptake inhibitors (SSRIs) and blood pressure in patients with cardiovascular disease (CVD) and depression.

Method: This study was registered on PROSPERO (CRD42022368655) and conducted in accordance with PRISMA 2020. The databases included PubMed, Web of Science, and EMBASE. The inclusion date was from the inception date through Oct. 26, 2022.Review Manager version 5.3 and Stata version 12.0 were used for data analysis.

Results: This meta-analysis included six studies, and a total number of 149 patients with CVD and depression . In the group analysis, SSRIs treatment had no effect on the systolic blood pressure (SBP) (MD = 1.01, 95%CI:-2.88, 4.90, P = 0.61) and diastolic blood pressure (DBP) (MD = 0.64, 95%CI:-1.03, 2.31, P = 0.45). In the subgroup analysis, SSRIs treatment had no effect on SBP for patients with hypertension (MD = -8.02, 95%CI:-16.84, 0.81, P = 0.08), and patients with other CVD (MD = 3.18, 95%CI:-1.15, 7.52, P = 0.15). For patients with hypertension, SSRIs treatment significantly lowered DBP (MD = -5.75, 95%CI:-10.84, -0.67, P = 0.03). But SSRIs treatment had no impact on DBP for patients with other CVD (MD = 1.41, 95%CI:-0.36, 3.18, P = 0.12). Subgroup analysis of the treatment period and the country had no significant impact on SBP and DBP. In the sensitivity analysis, there was no significant change after omitting one study in both SBP and DBP group analysis. Egger's test showed no publication bias of SBP (P = 0.183) and DBP group analysis (P = 0.392).

Conclusion: SSRIs help to lower DBP in hypertensive patients with depression. The potential pathophysiological mechanisms may lie in serotonin function, sympathetic activation and genetic heterogeneity. Further clinic and experimental researches need to be conducted on SSRIs and blood pressure.

Competing Interests: Declaration of competing interest All the authors declared that there was no conflict of interest in this paper.

Titel:	A meta-analysis on the association between SSRIs and blood pressure in patients with CVD and depression.
Autor/in / Beteiligte Person:	Zhang, L ; Li, G ; Liu, M
Zeitschrift:	Journal of affective disorders, Jg. 340 (2023-11-01), S. 181-188
Veröffentlichung:	Amsterdam, Elsevier/North-Holland Biomedical Press., 2023
Medientyp:	academicJournal
ISSN:	1573-2517 (electronic)
DOI:	10.1016/j.jad.2023.08.032
Schlagwort:	Humans Blood Pressure Selective Serotonin Reuptake Inhibitors adverse effects Depression drug therapy Serotonin Cardiovascular Diseases Hypertension drug therapy
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Meta-Analysis; Journal Article; Review; Research Support, Non-U.S. Gov't Language: English [J Affect Disord] 2023 Nov 01; Vol. 340, pp. 181-188. <i>Date of Electronic Publication: </i>2023 Aug 07. MeSH Terms: Cardiovascular Diseases* ; Hypertension* / drug therapy ; Humans ; Blood Pressure ; Selective Serotonin Reuptake Inhibitors / adverse effects ; Depression / drug therapy ; Serotonin Contributed Indexing: Keywords: Blood pressure; Cardiovascular disease; Depression; Hypertension; SSRIs Substance Nomenclature: 0 (Selective Serotonin Reuptake Inhibitors) ; 333DO1RDJY (Serotonin) Entry Date(s): Date Created: 20230809 Date Completed: 20230911 Latest Revision: 20230912 Update Code: 20240514

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A meta-analysis on the association between SSRIs and blood pressure in patients with CVD and depression.