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Depression is a prevalent condition among cancer patients and significantly impacts their quality of life. Traditional Chinese Medicine, particularly Chinese Herbal Medicine (CHM), has shown potential in both anti-tumor and anti-depressive effects. However, there is a dearth of scientific literature exploring the association between CHM treatment and depression in cancer patients. This study aims to investigate the relationship between CHM treatment and depression in cancer patients. A cross-sectional study was conducted among cancer outpatients at Longhua Hosiptal, Shanghai University of Traditional Chinese Medicine, from June 2020 to April 2021 (Ethical approval number: 2020LCSY057). All patients signed informed consent and completed The European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (EORTC QLQ-C30). Hamilton depression scale was evaluated depression by psychiatrists. The power of the sample size was determined using Gpower statistical and SPSS were used for statistical analysis. A total of 809 completed the study. Gender, medical insurance, the classification of time since diagnosis, ECOG, cancer stage, metastasis, gene mutation, treatment plan and CHM treatment were an important factor affecting depression (P < .05). Further analysis investigated the impact of CHM treatment on depression. There were 374 enrolled in CHM group and 435 enrolled in Non-CHM group. The assessment results of Hamilton depression scale and EORTC QLQ-C30 in CHM group were superior to those in Non-CHM group. The morbidity of depression is 50.27% in CHM group and 66.44% in Non-CHM group. After adjusting for potential confounders (gender, medical insurance, cancer stage, etc.), CHM treatment indicated negative correlation with depression (Odds ratio (OR) = 0.7, 95% confidence interval (CI): 0.5-0.9, P = .020). The interaction effects within each subgroup were no significantly affect the relationship between CHM treatment and depression (P > .05). CHM treatment was an independent protective factor for depression in cancer patients, and lead to better quality of life for cancer patients.

Competing Interests: The authors have no conflicts of interest to disclose.

Titel:	Association between Chinese herbal medicine (CHM) treatment and depression among cancer patients in China: An outpatient-based cross-sectional study.
Autor/in / Beteiligte Person:	Lin, H ; Zhang, X ; Zhang, Y ; Cui, W ; Jia, F ; Wang, J
Link:	Full Text Finder (Volltext)
Zeitschrift:	Medicine, Jg. 102 (2023-08-25), Heft 34, S. e34695
Veröffentlichung:	Hagerstown, Md : Lippincott Williams & Wilkins, 2023
Medientyp:	academicJournal
ISSN:	1536-5964 (electronic)
DOI:	10.1097/MD.0000000000034695
Schlagwort:	Humans Outpatients Cross-Sectional Studies Depression drug therapy Depression epidemiology Quality of Life China epidemiology Medicine, Chinese Traditional Drugs, Chinese Herbal therapeutic use Neoplasms complications
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Medicine (Baltimore)] 2023 Aug 25; Vol. 102 (34), pp. e34695. MeSH Terms: Drugs, Chinese Herbal* / therapeutic use ; Neoplasms* / complications ; Humans ; Outpatients ; Cross-Sectional Studies ; Depression / drug therapy ; Depression / epidemiology ; Quality of Life ; China / epidemiology ; Medicine, Chinese Traditional References: J Affect Disord. 2011 Jun;131(1-3):1-7. (PMID: 20732716) ; Pharmacol Res. 2019 Dec;150:104520. (PMID: 31706012) ; J Natl Cancer Inst. 1993 Mar 3;85(5):365-76. (PMID: 8433390) ; Evid Based Complement Alternat Med. 2018 Nov 18;2018:3967642. (PMID: 30581482) ; Future Oncol. 2021 Jan;17(2):183-196. (PMID: 33305608) ; N Engl J Med. 2000 Dec 21;343(25):1826-32. (PMID: 11117973) ; J Neurol Neurosurg Psychiatry. 1960 Feb;23:56-62. (PMID: 14399272) ; Cochrane Database Syst Rev. 2015 Jun 01;(6):CD011006. (PMID: 26029972) ; Cell Death Differ. 2021 Feb;28(2):606-625. (PMID: 33462414) ; Psychooncology. 2019 Jun;28(6):1159-1183. (PMID: 30865357) ; Am J Chin Med. 2019;47(6):1223-1235. (PMID: 31505937) ; J Pain Symptom Manage. 2016 Apr;51(4):728-747. (PMID: 26880252) ; Complement Ther Med. 2016 Feb;24:55-62. (PMID: 26860802) ; Food Chem Toxicol. 2021 Mar;149:111960. (PMID: 33385512) ; Int Rev Psychiatry. 2014 Feb;26(1):16-30. (PMID: 24716498) ; Support Care Cancer. 2020 Jan;28(1):211-220. (PMID: 31001695) ; Am J Transl Res. 2020 Oct 15;12(10):6637-6645. (PMID: 33194060) ; Comb Chem High Throughput Screen. 2017;20(5):423-429. (PMID: 28093974) ; Oncotarget. 2015 Nov 24;6(37):39725-39. (PMID: 26498685) ; J Affect Disord. 2012 Dec 10;141(2-3):343-51. (PMID: 22727334) ; Clin Cancer Res. 2019 Oct 1;25(19):5759-5765. (PMID: 31175096) ; Health Psychol. 2000 Mar;19(2):107-14. (PMID: 10762094) ; Front Psychol. 2022 Aug 18;13:884337. (PMID: 36059752) ; Trials. 2019 Dec 17;20(1):741. (PMID: 31847861) ; Am J Chin Med. 2020;48(7):1577-1592. (PMID: 33202152) ; Int Psychogeriatr. 2016 Dec;28(12):2019-2028. (PMID: 27468967) ; Asian Pac J Cancer Prev. 2018 Jun 25;19(6):1661-1669. (PMID: 29938451) ; Behav Res Methods. 2007 May;39(2):175-91. (PMID: 17695343) ; Psychosom Med. 1987 Sep-Oct;49(5):435-49. (PMID: 3671633) ; J Epidemiol. 2004 Nov;14(6):193-203. (PMID: 15617393) ; Neuropsychiatr Dis Treat. 2017 Nov 28;13:2903-2911. (PMID: 29238195) ; Cancer Med. 2019 May;8(5):1958-1975. (PMID: 30945475) Substance Nomenclature: 0 (Drugs, Chinese Herbal) Entry Date(s): Date Created: 20230901 Date Completed: 20230904 Latest Revision: 20230905 Update Code: 20240514 PubMed Central ID: PMC10470751

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Association between Chinese herbal medicine (CHM) treatment and depression among cancer patients in China: An outpatient-based cross-sectional study.