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Stem cells have been regarded with promising application potential in tissue engineering and regenerative medicine due to their self-renewal and multidirectional differentiation abilities. However, their fate is relied on their local microenvironment, or niche. Recent studied have demonstrated that biophysical factors, defined as physical microenvironment in which stem cells located play a vital role in regulating stem cell committed differentiation. In vitro , synthetic physical microenvironments can be used to precisely control a variety of biophysical properties. On this basis, the effect of biophysical properties such as matrix stiffness, matrix topography and mechanical force on the committed differentiation of stem cells was further investigated. This paper summarizes the approach of mechanical models of artificial physical microenvironment and reviews the effects of different biophysical characteristics on stem cell differentiation, in order to provide reference for future research and development in related fields.

Titel:	[Differentiation of stem cells regulated by biophysical cues].
Autor/in / Beteiligte Person:	Li, C ; Fan, Y ; Zheng, L
Zeitschrift:	Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi, Jg. 40 (2023-08-25), Heft 4, S. 609-616
Veröffentlichung:	Chengdu : Sichuan Sheng sheng wu yi xue gong cheng xue hui ; <i>Original Publication</i>: Chengdu : Sichuan Sheng sheng wu yi xue gong cheng xue hui : Hua xi yi ke da xue : Chengdu ke ji da xue,, 2023
Medientyp:	academicJournal
ISSN:	1001-5515 (print)
DOI:	10.7507/1001-5515.202208002
Schlagwort:	Cell Differentiation Regenerative Medicine Tissue Engineering Cues Stem Cells
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: Chinese Publication Type: English Abstract; Journal Article Language: Chinese [Sheng Wu Yi Xue Gong Cheng Xue Za Zhi] 2023 Aug 25; Vol. 40 (4), pp. 609-616. MeSH Terms: Cues* ; Stem Cells* ; Cell Differentiation ; Regenerative Medicine ; Tissue Engineering References: Bioengineering (Basel). 2021 Jul 28;8(8):. (PMID: 34436111) ; Dev Cell. 2004 Apr;6(4):483-95. (PMID: 15068789) ; Cell Mol Bioeng. 2018 Aug 02;12(1):85-97. (PMID: 31719900) ; World J Stem Cells. 2020 Jan 26;12(1):25-34. (PMID: 32110273) ; Front Cell Dev Biol. 2021 Mar 25;9:640388. (PMID: 33842464) ; Stem Cells. 2018 Jan;36(1):22-35. (PMID: 29047191) ; Stem Cells Int. 2019 Nov 15;2019:1847098. (PMID: 31827524) ; Trends Cell Biol. 2023 Feb;33(2):112-123. (PMID: 35934562) ; Mater Sci Eng C Mater Biol Appl. 2020 Jan;106:110163. (PMID: 31753334) ; Nat Biomed Eng. 2019 Feb;3(2):90-104. (PMID: 30944433) ; Nat Mater. 2019 Dec;18(12):1366-1375. (PMID: 31477904) ; Stem Cell Rev Rep. 2020 Aug;16(4):661-674. (PMID: 32372248) ; Biophys J. 2018 Apr 24;114(8):1988-2000. (PMID: 29694875) ; Biomimetics (Basel). 2021 Dec 31;7(1):. (PMID: 35076475) ; Adv Exp Med Biol. 2020;1250:141-155. (PMID: 32601943) ; JAMA Oncol. 2016 Jul 1;2(7):908-14. (PMID: 26967465) ; Acta Biomater. 2020 Jan 15;102:114-126. (PMID: 31756551) ; Adv Sci (Weinh). 2021 Feb 18;8(7):2002112. (PMID: 33854874) ; Nat Biomed Eng. 2022 Apr;6(4):351-371. (PMID: 35478225) ; Biofabrication. 2021 Oct 04;13(4):. (PMID: 34551404) ; J Zhejiang Univ Sci B. 2020 Nov.;21(11):871-884. (PMID: 33150771) ; J Biomed Mater Res A. 2020 Oct;108(10):2080-2089. (PMID: 32319192) ; World J Stem Cells. 2021 Jul 26;13(7):894-913. (PMID: 34367483) ; Ann Transl Med. 2020 Dec;8(23):1598. (PMID: 33437797) ; Acta Biomater. 2021 Oct 1;133:126-138. (PMID: 34365041) ; JAMA Netw Open. 2020 Sep 1;3(9):e2016236. (PMID: 32910197) ; Cells. 2021 Nov 11;10(11):. (PMID: 34831345) ; Am J Transl Res. 2019 Jan 15;11(1):233-244. (PMID: 30787982) ; Ann Biomed Eng. 2020 Feb;48(2):893-902. (PMID: 31802282) ; Nat Mater. 2015 Dec;14(12):1269-77. (PMID: 26366848) ; Biotechnol Bioeng. 2018 Aug;115(8):2013-2026. (PMID: 29665002) ; Ann Biomed Eng. 2020 Mar;48(3):1071-1089. (PMID: 31485876) ; Cell. 2006 Aug 25;126(4):677-89. (PMID: 16923388) ; Front Cell Dev Biol. 2020 Dec 09;8:606989. (PMID: 33363166) ; J Biomech. 2016 Feb 29;49(4):572-9. (PMID: 26892895) ; Biotechnol Adv. 2020 Sep - Oct;42:107421. (PMID: 31381963) ; Sci Transl Med. 2021 Jul 7;13(601):. (PMID: 34233948) ; Trends Biotechnol. 2020 Jun;38(6):594-605. (PMID: 32407688) ; Nanomaterials (Basel). 2020 Oct 20;10(10):. (PMID: 33092104) ; J Tissue Eng Regen Med. 2018 Feb;12(2):341-348. (PMID: 28488350) ; Annu Rev Biochem. 2022 Jun 21;91:505-540. (PMID: 35303787) ; Materials (Basel). 2022 Feb 25;15(5):. (PMID: 35268983) ; ACS Appl Mater Interfaces. 2020 Jul 22;12(29):32328-32339. (PMID: 32597164) ; Science. 1991 Nov 22;254(5035):1146-53. (PMID: 1659742) ; Nat Rev Drug Discov. 2020 Jul;19(7):463-479. (PMID: 32612263) ; FASEB J. 2020 Sep;34(9):12976-12990. (PMID: 33411380) ; Tissue Eng Part B Rev. 2020 Dec;26(6):498-518. (PMID: 32272868) ; Front Cell Dev Biol. 2022 Jan 21;10:808303. (PMID: 35127684) ; Acta Biochim Biophys Sin (Shanghai). 2020 Jul 10;52(7):736-748. (PMID: 32445460) ; Int J Nanomedicine. 2021 Sep 21;16:6477-6496. (PMID: 34584412) ; Drug Discov Today. 2014 Jun;19(6):763-73. (PMID: 24508818) ; Cell Biosci. 2021 May 17;11(1):88. (PMID: 34001272) ; Biophys J. 2019 Jul 9;117(1):129-142. (PMID: 31178039) ; Regen Biomater. 2021 Nov 18;8(6):rbab066. (PMID: 34868635) ; Free Radic Biol Med. 2021 Jun;169:62-73. (PMID: 33862162) ; Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4872-7. (PMID: 20194780) ; Science. 2008 Dec 12;322(5908):1687-91. (PMID: 19074349) ; Biomaterials. 2019 Jan;188:187-197. (PMID: 30366219) ; Arch Oral Biol. 2021 May;125:105092. (PMID: 33652301) ; Acta Biomater. 2021 Apr 15;125:112-125. (PMID: 33582360) Contributed Indexing: Keywords: Biophysical cues; Differentiation; Microenvironment; Stem cells ; Local Abstract: [Publisher, Chinese] 干细胞具有自我更新和多向分化的能力，在组织工程和再生医学领域被认为有广泛的应用前景。然而，干细胞的功能依赖于自身所处的微环境即干细胞龛。干细胞龛中包含复杂的生物物理和生物化学因素。最近的研究表明，生物物理因素即干细胞所处的物理微环境在调控干细胞定向分化中发挥着重要的作用。在体外，人工合成的物理微环境能够精确操控多种生物物理特性。在此基础上，研究者进一步开展了如基质硬度、基质形貌和机械力等生物物理特性对各种不同种类的干细胞定向分化功能影响的研究。本文总结了人工构建物理微环境的手段及力学模型，并且综述了不同生物物理特性对干细胞分化影响的研究现状，希望对今后相关领域的研究发展提供参考借鉴。. Entry Date(s): Date Created: 20230904 Date Completed: 20230906 Latest Revision: 20231021 Update Code: 20231215 PubMed Central ID: PMC10477397

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[Differentiation of stem cells regulated by biophysical cues].