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Objectives: To compare the inter-modality consistency and diagnostic performances of the contrast-enhanced ultrasound (CEUS) Liver Imaging Reporting and Data System (LI-RADS) and contrast-enhanced computed tomography (CECT) LI-RADS in patients at risk for hepatocellular carcinoma (HCC), so as to help clinicians to select a more appropriate modality to follow the focal liver lesions (FLLs).

Methods: This retrospective study included untreated 277 FLLs from 247 patients who underwent both CEUS and CECT within 1 month. The ultrasound contrast medium used was SonoVue. FLL categories were independently assigned by two ultrasound physicians and two radiologists using CEUS LI-RADS v2017 and CECT LI-RADS v2018, respectively. The diagnostic performances of CEUS and CECT LI-RADS were evaluated using sensitivity, specificity, positive predictive value (PPV), and negative predictive value. Cohen's Kappa was employed to evaluate the concordance of the LI-RADS category.

Results: The inter-modality consistency for CEUS and CECT LI-RADS was 0.31 (p < 0.001). HCC was more frequently observed in CECT LR-3 and LR-4 hepatic lesions than in CEUS (7.3% vs. 19.5%, p < 0.001). The specificity and PPV of CEUS and CECT LR-5 for the diagnosis of HCC were 89.5%, 95.0%, and 82.5%, 94.4%, respectively. The sensitivity of CEUS LR-5 + LR-M for the diagnosis of hepatic malignancies was higher than that of CECT (93.7% vs. 82.7%, p < 0.001). The specificity and PPV of CEUS LR-M for the diagnosis of non-HCC malignancies were lower than those of CECT (59.7% vs. 95.5%, p < 0.001; 23.4% vs. 70.3%, p < 0.001).

Conclusions: The inter-modality consistency between the CEUS and CECT LI-RADS categories is fair. CEUS LI-RADS was more sensitive than CECT LI-RADS in terms of identifying hepatic malignancies, but weaker in terms of separating HCC from non-HCC malignancies.

Titel:	Differences between CEUS LI-RADS and CECT LI-RADS in the diagnosis of focal liver lesions in patients at risk for HCC.
Autor/in / Beteiligte Person:	Wen, R ; Huang, W ; Song, R ; Qin, L ; Wu, Y ; Peng, Y ; Huang, X ; He, Y ; Yang, H
Link:	View record at Springer (Volltext)
Zeitschrift:	BMC medical imaging, Jg. 23 (2023-09-11), Heft 1, S. 122
Veröffentlichung:	London : BioMed Central, [2001-, 2023
Medientyp:	academicJournal
ISSN:	1471-2342 (electronic)
DOI:	10.1186/s12880-023-01088-1
Schlagwort:	Humans Retrospective Studies Tomography, X-Ray Computed Contrast Media Carcinoma, Hepatocellular diagnostic imaging Liver Neoplasms diagnostic imaging
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [BMC Med Imaging] 2023 Sep 11; Vol. 23 (1), pp. 122. <i>Date of Electronic Publication: </i>2023 Sep 11. MeSH Terms: Carcinoma, Hepatocellular* / diagnostic imaging ; Liver Neoplasms* / diagnostic imaging ; Humans ; Retrospective Studies ; Tomography, X-Ray Computed ; Contrast Media References: Ultrasound Med Biol. 2020 May;46(5):1216-1223. (PMID: 32115307) ; Hepatol Int. 2010 Mar 18;4(2):439-74. (PMID: 20827404) ; Radiology. 2018 Dec;289(3):816-830. (PMID: 30251931) ; Eur J Radiol. 2019 Nov;120:108685. (PMID: 31606712) ; Liver Int. 2020 Oct;40(10):2345-2352. (PMID: 32722894) ; Acad Radiol. 2016 Mar;23(3):344-52. (PMID: 26777590) ; Abdom Radiol (NY). 2018 Jan;43(1):127-142. (PMID: 28819825) ; J Am Coll Radiol. 2020 Oct;17(10):1199-1206. (PMID: 32640250) ; Radiology. 2020 Feb;294(2):299-307. (PMID: 31769742) ; Eur Radiol. 2021 Feb;31(2):847-854. (PMID: 32803416) ; J Hepatol. 2018 Jul;69(1):182-236. (PMID: 29628281) ; Eur Radiol. 2017 Oct;27(10):4394-4405. (PMID: 28374073) ; Clin Gastroenterol Hepatol. 2019 Jun;17(7):1228-1238. (PMID: 30326302) ; Eur Radiol. 2020 Jan;30(1):461-470. (PMID: 31297632) ; Ann Transl Med. 2021 Jul;9(13):1076. (PMID: 34422988) ; AJR Am J Roentgenol. 2016 Feb;206(2):307-12. (PMID: 26797357) ; Eur Radiol. 2018 Oct;28(10):4254-4264. (PMID: 29675659) ; Hepatology. 2018 Aug;68(2):723-750. (PMID: 29624699) ; Eur Radiol. 2019 Aug;29(8):4249-4257. (PMID: 30569182) ; AJR Am J Roentgenol. 2007 Jul;189(1):W7-W12. (PMID: 17579140) Contributed Indexing: Keywords: Computed tomography; Hepatocellular carcinoma; Liver Imaging Reporting and Data System; Ultrasonography Substance Nomenclature: 0 (Contrast Media) Entry Date(s): Date Created: 20230911 Date Completed: 20230913 Latest Revision: 20231123 Update Code: 20240513 PubMed Central ID: PMC10496202

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Differences between CEUS LI-RADS and CECT LI-RADS in the diagnosis of focal liver lesions in patients at risk for HCC.