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Background: The administration of contrast medium is associated with acute kidney injury; however, the effect of exposure of a deceased organ donor to contrast medium on kidney transplant outcomes has been poorly studied.

Methods: A retrospective analysis of all deceased kidney donors between 2011 and 2021 and their corresponding recipients in the Netherlands was conducted. Multivariable analyses were performed to assess the associations between contrast medium exposure and delayed graft function (DGF)/graft survival. Linear mixed models were used to assess the differences in mean estimated glomerular filtration rate values in recipients 1 to 6 y after transplantation.

Results: In total, 2177 donors and 3638 corresponding kidney graft recipients were included. Twenty-four percent of the donors (n = 520) were exposed to contrast medium, corresponding to 23% of recipients (n = 832). DGF was observed in 36% (n = 1321) and primary nonfunction in 3% (n = 122) of recipients. DGF rates for donation after brain death (DBD) and donation after circulatory death (DCD) donors showed no significant effect of contrast medium exposure ( P = 0.15 and P = 0.60 for DBD and DCD donors, respectively). In multivariable analyses, contrast medium administration was not significantly associated with a higher DGF risk (odds ratio 1.06; 95% confidence interval, 0.86-1.36; P = 0.63) nor was a significant predictor for death-censored graft failure (hazard ratio 1.01; 95% confidence interval, 0.77-1.33; P = 0.93). Linear mixed models showed no difference in mean estimated glomerular filtration rate values in recipients 1 to 6 y posttransplantation ( P = 0.78).

Conclusions: This study indicates that contrast medium administration in DBD and DCD donors has no negative effect on early and long-term kidney graft function.

Competing Interests: The authors declare no funding or conflicts of interest.

Titel:	Transplant Outcomes After Exposure of Deceased Kidney Donors to Contrast Medium.
Autor/in / Beteiligte Person:	Chotkan, KA ; Hilbrands, LB ; Putter, H ; Konjin, C ; Schaefer, B ; Beenen, LFM ; Pol, RA ; Braat, AE
Zeitschrift:	Transplantation, Jg. 108 (2024), Heft 1, S. 252-260
Veröffentlichung:	Hagerstown, MD : Lippincott Williams & Wilkins ; <i>Original Publication</i>: Baltimore, Williams & Wilkins., 2024
Medientyp:	academicJournal
ISSN:	1534-6080 (electronic)
DOI:	10.1097/TP.0000000000004745
Schlagwort:	Humans Retrospective Studies Graft Survival Tissue Donors Brain Death Delayed Graft Function etiology Kidney Transplantation adverse effects Tissue and Organ Procurement
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Transplantation] 2024 Jan 01; Vol. 108 (1), pp. 252-260. <i>Date of Electronic Publication: </i>2023 Sep 06. MeSH Terms: Kidney Transplantation* / adverse effects ; Tissue and Organ Procurement* ; Humans ; Retrospective Studies ; Graft Survival ; Tissue Donors ; Brain Death ; Delayed Graft Function / etiology References: Berthier E, Ridereau-Zins C, Dubé L, et al. Simultaneous CT angiography and whole-body CT is an effective imaging approach before multiorgan retrieval. Diagn Interv Imaging. 2017;98:235–243. ; Gauthier JM, Bierhals AJ, Liu J, et al. Chest computed tomography imaging improves potential lung donor assessment. J Thorac Cardiovasc Surg. 2019;157:1711–1718.e1. ; Mensink JW, Pol RA, Nijboer WN, et al. Whole body CT imaging in deceased donor screening for malignancies. Transplant Direct. 2019;5:e509. ; Bozovic G, Adlercreutz C, Höglund P, et al. 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Transplant Outcomes After Exposure of Deceased Kidney Donors to Contrast Medium.