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Background: The value of the widely applied maternal cytomegalovirus (CMV) serological testing approach in predicting intrauterine transmission in highly seroprevalent regions remains unknown.

Methods: A nested case-control study was conducted based on a maternal-child cohort study. Newborns with congenital CMV (cCMV) infection were included, and each of them was matched to 3 newborns without cCMV infection. Retrospective samples were tested for immunoglobulin G (IgG) avidity and immunoglobulin M (IgM) antibodies in maternal serum and CMV DNA in maternal blood and urine to analyze their associations with cCMV infection.

Results: Forty-eight newborns with cCMV infection and 144 matched newborns without infection were included in the study. Maternal IgM antibodies and IgG avidity during pregnancy were not statistically associated with intrauterine transmission. The presence of CMV DNAemia indicated a higher risk of cCMV infection, with odds ratio values of 5.7, 6.5, and 13.0 in early, middle, and late pregnancy, respectively. However, the difference in CMV shedding rates in transmitters and nontransmitters was not significant in urine.

Conclusions: The value of current maternal CMV serological testing in regions with high seropositivity rates is very limited and should be reconsidered. The detection of DNAemia would be helpful in assessing the risk of intrauterine transmission.

Competing Interests: Potential conflicts of interest. All authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

Titel:	Reconsideration of Maternal Serological Testing for Predicting Congenital CMV Infection.
Autor/in / Beteiligte Person:	Huang, Y ; Tang, J ; Yu, H ; Song, Q ; Hao, M ; Wang, H ; Liu, J ; Dong, Y ; Liang, M ; Zhuang, S ; Li, C ; Wang, J ; Liang, C ; Su, Y ; Li, T ; Wu, T ; Ge, S ; Zhang, J ; Xia, N
Zeitschrift:	The Journal of infectious diseases, Jg. 229 (2024-06-14), Heft 6, S. 1817-1822
Veröffentlichung:	Jan. 2011- : Oxford : Oxford University Press ; <i>Original Publication</i>: 1904-2010 : Chicago, IL : University of Chicago Press, 2024
Medientyp:	academicJournal
ISSN:	1537-6613 (electronic)
DOI:	10.1093/infdis/jiad412
Schlagwort:	Humans Female Pregnancy Case-Control Studies Infant, Newborn Adult Retrospective Studies Serologic Tests methods Antibody Affinity Male Cohort Studies Cytomegalovirus Infections diagnosis Cytomegalovirus Infections immunology Cytomegalovirus Infections urine Cytomegalovirus Infections transmission Cytomegalovirus Infections congenital Infectious Disease Transmission, Vertical Immunoglobulin M blood Antibodies, Viral blood Immunoglobulin G blood Pregnancy Complications, Infectious virology Pregnancy Complications, Infectious diagnosis Cytomegalovirus immunology Cytomegalovirus isolation & purification DNA, Viral urine DNA, Viral blood
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [J Infect Dis] 2024 Jun 14; Vol. 229 (6), pp. 1817-1822. MeSH Terms: Cytomegalovirus Infections* / diagnosis ; Cytomegalovirus Infections* / immunology ; Cytomegalovirus Infections* / urine ; Cytomegalovirus Infections* / transmission ; Cytomegalovirus Infections* / congenital ; Infectious Disease Transmission, Vertical* ; Immunoglobulin M* / blood ; Antibodies, Viral* / blood ; Immunoglobulin G* / blood ; Pregnancy Complications, Infectious* / virology ; Pregnancy Complications, Infectious* / diagnosis ; Cytomegalovirus* / immunology ; Cytomegalovirus* / isolation & purification ; DNA, Viral* / urine ; DNA, Viral* / blood ; Humans ; Female ; Pregnancy ; Case-Control Studies ; Infant, Newborn ; Adult ; Retrospective Studies ; Serologic Tests / methods ; Antibody Affinity ; Male ; Cohort Studies Grant Information: 81973058 National Natural Science Foundation of China; Science and Technology Key Project of Fujian Province; 2020YZ015004 Fujian Province; 2021ZD01006 Fujian Provincial Health Commission; 20720220006 Fundamental Research Funds for the Central Universities Contributed Indexing: Keywords: congenital infection; cytomegalovirus; pregnant woman; serology; virology Substance Nomenclature: 0 (Immunoglobulin M) ; 0 (Antibodies, Viral) ; 0 (Immunoglobulin G) ; 0 (DNA, Viral) Entry Date(s): Date Created: 20230922 Date Completed: 20240613 Latest Revision: 20240613 Update Code: 20240614

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Reconsideration of Maternal Serological Testing for Predicting Congenital CMV Infection.