PEGylated curcumin-loaded poly(vinyl alcohol)/Zwitterionic poly(sulfobetaine vinylimidazole)-grafted chitosan nanofiber as a second-degree burn wound dressing.
In: Carbohydrate polymers, Jg. 321 (2023-12-01), S. 121307
academicJournal
Zugriff:
Burn injuries damage skin function and increased the risk of infection. Using natural-inspired antibiotic-free nanofibrous in wound healing has attracted increasing attention. Here, mPEG-Curcumin (mPEG-CUR) was synthesized through a novel, cheap, and high-efficiency method, and incorporated onto poly(vinyl alcohol) (PVA)/zwitterionic poly(sulfobetaine vinylimidazole)-grafted chitosan (CS-g-PNVIS) nanofiber. Due to the lack of electrospinning capability of CS-g-PNVIS and its brittleness, to obtain nanofibers with uniform and bead-free morphology, PVA was used as an electrospinning aid polymer, so that the prepared nanofibers have suitable mechanical properties with an average diameter between 115 ± 18-157 ± 39 nm. The heat-treated nanofibers have adequate swelling and dimensional stability. Time-killing assay proved the antibacterial activity of the mPEG-CUR-loaded nanofibers towards Gram-positive and Gram-negative bacterium. The MTT investigation illustrated the non-cytotoxicity and biocompatibility of the nanofibers. In vivo studies exhibited significant improvement in the mean wound area closure by applying mPEG-CUR nanofibers. The mPEG-CUR-loaded nanofibers showed the highest antioxidant (86 %) power after 40 min. Moreover, nanofibers possess a desirable WVT rate (3.4 ± 0.24-5.5 ± 0.3 kg/m 2 .d) and good breathability and had the potential to supply a suitable moist environment in the wounded area. This approach can be the beginning of a new path in designing a new generation of nanofiber mats for wound healing applications.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Titel: |
PEGylated curcumin-loaded poly(vinyl alcohol)/Zwitterionic poly(sulfobetaine vinylimidazole)-grafted chitosan nanofiber as a second-degree burn wound dressing.
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Autor/in / Beteiligte Person: | Shaabani, A ; Bizari, D ; Khoshmohabat, H |
Zeitschrift: | Carbohydrate polymers, Jg. 321 (2023-12-01), S. 121307 |
Veröffentlichung: | <1992-> : Barking : Elsevier Applied Science Publishers ; <i>Original Publication</i>: London [Eng.] : Applied Science Publishers, c1981-, 2023 |
Medientyp: | academicJournal |
ISSN: | 1879-1344 (electronic) |
DOI: | 10.1016/j.carbpol.2023.121307 |
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