Diagnostic accuracy of SSR-PET/CT compared to histopathology in the identification of liver metastases from well-differentiated neuroendocrine tumors.
In: Cancer imaging : the official publication of the International Cancer Imaging Society, Jg. 23 (2023-09-28), Heft 1, S. 92
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Zugriff:
Background: Histopathology is the reference standard for diagnosing liver metastases of neuroendocrine tumors (NETs). Somatostatin receptor-positron emission tomography / computed tomography (SSR-PET/CT) has emerged as a promising non-invasive imaging modality for staging NETs. We aimed to assess the diagnostic accuracy of SSR-PET/CT in the identification of liver metastases in patients with proven NETs compared to histopathology.
Methods: Histopathologic reports of 139 resected or biopsied liver lesions of patients with known NET were correlated with matching SSR-PET/CTs and the positive/negative predictive value (PPV/NPV), sensitivity, specificity, and diagnostic accuracy of SSR-PET/CT were evaluated. PET/CT reading was performed by one expert reader blinded to histopathology and clinical data.
Results: 133 of 139 (95.7%) liver lesions showed malignant SSR-uptake in PET/CT while initial histopathology reported on 'liver metastases of NET´ in 127 (91.4%) cases, giving a PPV of 91.0%. Re-biopsy of the initially histopathologically negative lesions (reference standard) nevertheless diagnosed 'liver metastases of NET' in 6 cases, improving the PPV of PET/CT to 95.5%. Reasons for initial false-negative histopathology were inadequate sampling in the sense of non-target biopsies. The 6 (4.3%) SSR-negative lesions were all G2 NETs with a Ki-67 between 2-15%.
Conclusion: SSR-PET/CT is a highly accurate imaging modality for the diagnosis of liver metastases in patients with proven NETs. However, we found that due to the well-known tumor heterogeneity of NETs, specifically in G2 NETs approximately 4-5% are SSR-negative and may require additional imaging with [ 18 F]FDG PET/CT.
(© 2023. International Cancer Imaging Society (ICIS).)
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Diagnostic accuracy of SSR-PET/CT compared to histopathology in the identification of liver metastases from well-differentiated neuroendocrine tumors.
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Autor/in / Beteiligte Person: | Fabritius, MP ; Soltani, V ; Cyran, CC ; Ricke, J ; Bartenstein, P ; Auernhammer, CJ ; Spitzweg, C ; Schnitzer, ML ; Ebner, R ; Mansournia, S ; Hinterberger, A ; Lohse, A ; Sheikh, GT ; Winkelmann, M ; Knösel, T ; Ingenerf, M ; Schmid-Tannwald, C ; Kunz, WG ; Rübenthaler, J ; Grawe, F |
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Zeitschrift: | Cancer imaging : the official publication of the International Cancer Imaging Society, Jg. 23 (2023-09-28), Heft 1, S. 92 |
Veröffentlichung: | <2014- > : London : Springer Nature ; <i>Original Publication</i>: London : e-med, c2000]-, 2023 |
Medientyp: | academicJournal |
ISSN: | 1470-7330 (electronic) |
DOI: | 10.1186/s40644-023-00614-2 |
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