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Purpose: To compare the diagnostic performance (detection, assessment of correct disease extent and multifocality/centricity) of Contrast-Enhanced Mammography (CEM) Versus Breast Magnetic Resonance (MRI) in the study of lobular neoplasms.

Methods: We retrospectively selected all the patients who underwent surgery for a lobular breast neoplasm, either an in situ or an invasive tumor, and had undergone both breast CEM and MRI examinations during the pre-surgical planning. Wilcoxon Signed Rank test was performed to assess the differences between size measurements using the different methods and the post-surgical pathological measurements, considered the gold standard. The agreement in identifying multifocality/multicentricity among the different methods and the pathology was assessed using the Kappa statistics.

Results: We selected 19 patients, of which one presented a bilateral neoplasm. Then, the images of these 19 patients were analyzed, for a total of 52 malignant breast lesions. We found no significant differences between the post-surgical pathological size of the lesions and the calculated size with CEM and MRI (p-value of the difference respectively 0.71 and 0.47). In all 20 cases, neoplasm detection was possible both with CEM and MRI. CEM and MRI showed an excellent ability to identify multifocal and multicentric cases (K statistic equal to 0.93 for both the procedures), while K statistic was 0.11 and 0.59 for FFDM and US, respectively.

Conclusion: The findings of this study suggest that CEM is a reliable imaging technique in the preoperative setting of patients with lobular neoplasm, with comparable results to breast MRI.

Titel:	Contrast-Enhanced Mammography (CEM) compared to Breast Magnetic Resonance (MRI) in the evaluation of breast lobular neoplasia.
Autor/in / Beteiligte Person:	Nicosia, L ; Rotili, A ; Pesapane, F ; Bozzini, AC ; Battaglia, O ; Pellegrino, G ; Fusco, N ; Porta, FM ; Frassoni, S ; Bagnardi, V ; Corso, G ; Sangalli, C ; Cassano, E
Link:	View record at Springer (Volltext)
Zeitschrift:	Breast cancer research and treatment, Jg. 203 (2024), Heft 1, S. 135-143
Veröffentlichung:	Dordrecht : Kluwer Academic ; <i>Original Publication</i>: The Hague ; Boston : M. Nijhoff, c1981-, 2024
Medientyp:	academicJournal
ISSN:	1573-7217 (electronic)
DOI:	10.1007/s10549-023-07096-7
Schlagwort:	Humans Female Retrospective Studies Contrast Media Mammography methods Magnetic Resonance Imaging methods Magnetic Resonance Spectroscopy Sensitivity and Specificity Breast Neoplasms diagnostic imaging Breast Neoplasms surgery
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Breast Cancer Res Treat] 2024 Jan; Vol. 203 (1), pp. 135-143. <i>Date of Electronic Publication: </i>2023 Oct 03. MeSH Terms: Breast Neoplasms* / diagnostic imaging ; Breast Neoplasms* / surgery ; Humans ; Female ; Retrospective Studies ; Contrast Media ; Mammography / methods ; Magnetic Resonance Imaging / methods ; Magnetic Resonance Spectroscopy ; Sensitivity and Specificity References: Łukasiewicz S, Czeczelewski M, Forma A, Baj J, Sitarz R, Stanisławek A (2021) Breast cancer-epidemiology, risk factors, classification, prognostic markers, and current treatment strategies-an updated review. Cancers (Basel) 13(17):4287. https://doi.org/10.3390/cancers13174287. 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Contrast-Enhanced Mammography (CEM) compared to Breast Magnetic Resonance (MRI) in the evaluation of breast lobular neoplasia.