Cross-sectional and longitudinal associations of dichlorodiphenyltrichloroethane (DDT) metabolites exposure with lung function alternation in the Chinese general adults.

Cao, X ; Tan, Q ; et al.

In: The Science of the total environment, Jg. 905 (2023-12-20), S. 167729

academicJournal

Exposure of dichlorodiphenyltrichloroethane (DDT) pesticide was suggested to be associated with adverse effects on the respiratory system. However, the effects of DDT exposure on lung function remain unclear. Our objectives were to investigate the potential associations of internal levels of DDT and its metabolites including dichlorodiphenyldichloroethylene (DDE) and dichlorodiphenyldichloroethane (DDD) with lung function. Serum DDT, DDE, and DDD concentrations and lung function were measured among 3968 general adults from the Wuhan-Zhuhai cohort. The cross-sectional and longitudinal associations of serum DDT and its metabolites with lung function were assessed using linear mixed models. The results showed negative dose-response relationships of serum DDT, DDE, and DDD levels with forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV 1 ). In the cross-sectional analyses, each 1-unit increase in natural log-transformed values of p,p'-DDE, o,p'-DDT, o,p'-DDE, or p,p'-DDD was significantly associated with a 25.77-, 44.84-, 51.13-, or 43.44-mL decrease in FVC, respectively. Each 1-unit increase in natural log-transformed values of o,p'-DDT, o,p'-DDE, o,p'-DDD, or p,p'-DDD was significantly associated with a 35.72-, 31.87-, 29.54-, or 36.80-mL decrease in FEV 1 , respectively. In the three-year longitudinal analyses, each 1-unit increase in natural log-transformed serum p,p'-DDT and p,p'-DDE was significantly associated with a 35.10 mL and 36.38 mL decrease in FVC, and a 26.32 mL and 32.37 mL decrease in FEV 1 , respectively. In conclusion, DDT and its metabolites exposure were associated with lung function decline in the general Chinese adult population.

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Titel:	Cross-sectional and longitudinal associations of dichlorodiphenyltrichloroethane (DDT) metabolites exposure with lung function alternation in the Chinese general adults.
Autor/in / Beteiligte Person:	Cao, X ; Tan, Q ; Wang, M ; Liang, R ; Yu, L ; Liu, Y ; Zhang, Y ; Zhou, M ; Chen, W
Zeitschrift:	The Science of the total environment, Jg. 905 (2023-12-20), S. 167729
Veröffentlichung:	Amsterdam, Elsevier., 2023
Medientyp:	academicJournal
ISSN:	1879-1026 (electronic)
DOI:	10.1016/j.scitotenv.2023.167729
Schlagwort:	Adult Humans DDT analysis Dichlorodiphenyl Dichloroethylene Cross-Sectional Studies East Asian People Lung metabolism Hydrocarbons, Chlorinated analysis Pesticides analysis
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Sci Total Environ] 2023 Dec 20; Vol. 905, pp. 167729. <i>Date of Electronic Publication: </i>2023 Oct 10. MeSH Terms: Hydrocarbons, Chlorinated* / analysis ; Pesticides* / analysis ; Adult ; Humans ; DDT / analysis ; Dichlorodiphenyl Dichloroethylene ; Cross-Sectional Studies ; East Asian People ; Lung / metabolism Contributed Indexing: Keywords: DDE; DDT; General population; Lung function; Organochlorine Substance Nomenclature: D4K93Z1TBH (o,p'-DDT) ; CIW5S16655 (DDT) ; 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene) ; DM084YLQ1L (2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene) ; 0 (Hydrocarbons, Chlorinated) ; 0 (Pesticides) Entry Date(s): Date Created: 20231011 Date Completed: 20231115 Latest Revision: 20231122 Update Code: 20231215

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