Correlation between Spectral CT Parameters and Ki67 Expression in Hepatocellular Carcinoma.
In: Current medical imaging, 2023-10-14
academicJournal
Zugriff:
Objective: The objective of this study was to analyze the relationship between quantitative parameters of spectral CT and the Ki67 expression index of tumor cells in hepatocellular carcinoma (HCC).
Methods: A total of 19 patients who underwent preoperative spectral CT dual-phase enhancement and who were diagnosed with HCC by postoperative pathology were prospectively selected. Patients with ≥10% Ki67-positive tumor cells formed a high-Ki67 group, and those with <10% Ki67- positive cells formed a low-Ki67 group. The iodine concentrations (ICs) of the lesion and the descending aorta were measured during the arterial and venous phases. Relative iodine concentration (RIC) was calculated thus: RIC=IC lesion /IC descending aorta . CT values of the lesions at 40 and 70 keV were measured during the enhanced arterial and venous phases. The slope of the spectral curve (λ) was calculated thus: λ = (40 keV-70 keV) /(70-30). To compare the differences in quantitative parameters between the high- and low-Ki67 groups, either an independent samples t-test (normal distribution) or a Mann-Whitney U test (non-normal distribution) was used. Receiver operating characteristic curves were used to evaluate the effectiveness of spectral CT parameters in distinguishing between high-Ki67 and low-Ki67 groups. Pearson correlation analysis was used to evaluate the correlation between spectral CT quantitative parameters and Ki67 expression.
Results: IC, RIC and λ values for the high-Ki67 group in arterial and venous phases were higher than those for the low-Ki67 group, P < 0.05. IC, RIC, and λ values in the arterial phase were 0.83, 0.89, and 0.75, respectively; in the venous phase, the values of these three parameters were 0.76, 0.77, and 0.69, respectively. IC, RIC, and λ were positively correlated with Ki67 expression in both arterial and venous phases, with a highest correlation of 0.82 for arterial-phase RIC.
Conclusion: The quantitative parameters of spectral CT in HCC were correlated with Ki67 expression. This finding may make it easier for clinicians to determine whether a tumor is high or low in Ki67 before surgery.
(Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Titel: |
Correlation between Spectral CT Parameters and Ki67 Expression in Hepatocellular Carcinoma.
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Autor/in / Beteiligte Person: | Xu, L ; Yu Sun, F ; Xian Li, G ; Zai Yang, L ; Xiao Zhuo, Y ; Xiao Hu, WXH ; Wen, X |
Zeitschrift: | Current medical imaging, 2023-10-14 |
Veröffentlichung: | Ahead of Print, 2023 |
Medientyp: | academicJournal |
ISSN: | 1573-4056 (electronic) |
DOI: | 10.2174/0115734056227641231004042735 |
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