[Determination of urinary N-acetyl-beta-D-glucosaminidase (NAG) excretion as a parameter of nephrotoxicity due to cis-platin and the effect of fosfomycin (FOM) on its nephrotoxicity].
In: Nihon Sanka Fujinka Gakkai zasshi, Jg. 38 (1986-11-01), Heft 11, S. 2037-44
academicJournal
Zugriff:
CDDP is often dose-limited owing to its nephrotoxicity. Urinary NAG was measured to evaluate the nephrotoxicity of CDDP in 18 patients (DIV: 12 patients, Intra-Peritoneal: 6 patients) with or without Fosfomycin. The gradual increase in urinary NAG activity was noted on repeating the therapy. 24 hour NAG excretion was correlated with that of urinary beta 2-microglobulin. However, urinary NAG was not correlated with Ccr 24 or BUN. Though Ccr 24 and BUN were normal, urinary NAG and beta 2-microglobulin markedly increased during CDDP therapy. Fosfomycin administration significantly decreased urinary NAG, which was increased by CDDP. These results indicate that: The measurement of urinary NAG and beta 2-microglobulin are most useful in estimating the nephrotoxicity of CDDP. Fosfomycin decreases the nephrotoxicity of CDDP.
Titel: |
[Determination of urinary N-acetyl-beta-D-glucosaminidase (NAG) excretion as a parameter of nephrotoxicity due to cis-platin and the effect of fosfomycin (FOM) on its nephrotoxicity].
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Autor/in / Beteiligte Person: | Matsuoka, R ; Inoue, T ; Miyamura, K ; Mizutani, K ; Koike, S ; Mori, H ; Kigawa, T |
Zeitschrift: | Nihon Sanka Fujinka Gakkai zasshi, Jg. 38 (1986-11-01), Heft 11, S. 2037-44 |
Veröffentlichung: | Tokyo, Nippon Sanka Fujinka Gakkai., 1986 |
Medientyp: | academicJournal |
ISSN: | 0300-9165 (print) |
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