Depressive Symptoms are Associated With C-Reactive Protein in Older Adults With Obesity.
In: Journal of geriatric psychiatry and neurology, Jg. 37 (2024-07-01), Heft 4, S. 332-338
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Zugriff:
Objectives: To test the hypothesis that depressive symptoms vary with high-sensitivity C-reactive protein (hs-CRP), among older adults with obesity.
Methods: This was a cross-sectional, secondary analysis of baseline data from two related lifestyle intervention trials. The study sample comprises 148 consecutively recruited, community-dwelling older adults (age >=65 years) without severe psychiatric illness and with body mass index >=30 kg/m 2 . Logarithmically transformed GDS was analyzed as the dependent variable. Independent variables included log-transformed hs-CRP and covariates: sex, age, and concurrent use of antidepressant medication at baseline. An additional analysis was performed using binary conversion of the GDS scores, wherein a cutoff score of 5 was considered positive for depressive symptoms.
Results: Sample mean GDS score was 2.7 (SD 3.0, range 0 - 14). A significant multivariate model of GDS scores (R 2 = .089, F = 3.5, P = .010) revealed log-transformed hs-CRP ( P = .017) and male sex ( P = .012) as associated with depressive symptoms. Supplemental analysis demonstrated associations between depressive symptoms and log-transformed hs-CRP (OR 2.17, P = .001) and between depressive symptoms and male sex (OR 3.78, P = .013). Univariate logistic regression found hs-CRP to be associated with depressive symptoms.
Conclusions: In older adults with obese BMI, male sex and higher hs-CRP are associated with depression, even in a group with relatively minimal depressive symptoms. Hs-CRP may offer clinical utility as a biomarker for depression among older adults with obese BMI, even among those with non-severe psychiatric symptomatology.
Competing Interests: Declaration of Conflicting InterestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Dr. Kunik is an unpaid member of the board of the Houston & Southeast Chapter of the Alzheimer’s Association, and he performs guardianship evaluations for the county probate court. Dr. Villareal is on the Clinical Trials Advisory Panel (CTAP) for the NIH-National Institute on Aging (NIA) and the Data and Safety Monitoring Board (DSMB) for several NIH-supported clinical trials. The other authors have nothing to disclose.
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Depressive Symptoms are Associated With C-Reactive Protein in Older Adults With Obesity.
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Autor/in / Beteiligte Person: | Heisey, HD ; Qualls, C ; Villareal, DT ; Segoviano-Escobar, MB ; Nava, MLD ; Gatchel, JR ; Kunik, ME |
Zeitschrift: | Journal of geriatric psychiatry and neurology, Jg. 37 (2024-07-01), Heft 4, S. 332-338 |
Veröffentlichung: | Thousand Oaks, CA : Sage Publications ; <i>Original Publication</i>: [Littleton, MA] : PSG Pub. Co., [c1988-, 2024 |
Medientyp: | academicJournal |
ISSN: | 0891-9887 (print) |
DOI: | 10.1177/08919887231215041 |
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