Overexpression of the adhesion signaling pathway is linked to short-term survival in pancreatic ductal adenocarcinoma.

Aziz, MH ; Saida, L ; et al.

In: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], Jg. 24 (2024-02-01), Heft 1, S. 62-65

academicJournal

Wie komme ich dran?

Background and Objective: Pancreatic ductal adenocarcinoma (PDAC) is known for its unfavorable prognosis. Gaining insights into the molecular mechanisms that contribute to its progression is crucial for developing effective therapies. In this study, our objective was to investigate the molecular pathways associated with short-term survival in patients with PDAC.

Methods: Immune profiles were analyzed from both long-term survivors (n = 10) and short-term survivors (n = 10) after surgical resection. Pathway scores were calculated to compare the two groups.

Results: The "Adhesion" pathway emerged as the most significant pathway, exhibiting a notably higher score in the samples of short-term survivors (P < 0.009). Within this pathway, significant findings were observed in genes related to integrins and CEACAM.

Conclusion: The role of integrins in the tumor microenvironment of pancreatic cancer is of utmost importance, as they are found to be overexpressed in short-term survivors. These findings provide valuable insights into the underlying biology of PDAC and have potential implications for the development of therapeutic strategies.

Competing Interests: Declaration of competing interest The authors declare no conflict of interests regarding any financial disclosures nor commercial associations.

Titel:	Overexpression of the adhesion signaling pathway is linked to short-term survival in pancreatic ductal adenocarcinoma.
Autor/in / Beteiligte Person:	Aziz, MH ; Saida, L ; van Eijck CHJ ; Mustafa, DAM
Zeitschrift:	Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], Jg. 24 (2024-02-01), Heft 1, S. 62-65
Veröffentlichung:	2012- : New Delhi : Elsevier India ; <i>Original Publication</i>: Basel ; New York : Karger, c2001-, 2024
Medientyp:	academicJournal
ISSN:	1424-3911 (electronic)
DOI:	10.1016/j.pan.2023.11.001
Schlagwort:	Humans Prognosis Signal Transduction Integrins Tumor Microenvironment Pancreatic Neoplasms pathology Carcinoma, Pancreatic Ductal pathology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Pancreatology] 2024 Feb; Vol. 24 (1), pp. 62-65. <i>Date of Electronic Publication: </i>2023 Nov 08. MeSH Terms: Pancreatic Neoplasms* / pathology ; Carcinoma, Pancreatic Ductal* / pathology ; Humans ; Prognosis ; Signal Transduction ; Integrins ; Tumor Microenvironment Substance Nomenclature: 0 (Integrins) Entry Date(s): Date Created: 20231113 Date Completed: 20240129 Latest Revision: 20240129 Update Code: 20240129

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.