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Cues associated with smoking can induce relapse, which is likely driven by cue-induced neurobiological and physiological mechanisms. For instance, greater relapse vulnerability is associated with increases in cue-induced insula activation and heightened cortisol concentrations. Determining if there is a link between such cue-induced responses is critical given the need for biomarkers that can be easily measured in clinical settings and used to drive targeted treatment. Further, comprehensively characterising biological reactions to cues promises to aid in the development of therapies that address this specific relapse risk factor. To determine whether brain and cortisol responses to smoking cues are linked, this study recruited 27 nicotine-dependent tobacco-smoking individuals and acquired whole-brain functional activation during a cue reactivity task; salivary cortisol was measured before and after scanning. The results showed that increases in blood-oxygen-level-dependent activation in the right anterior insula and right dorsolateral prefrontal cortex (DLPFC) when viewing smoking versus neutral cues were positively correlated with a post-scan rise in salivary cortisol concentrations. These brain regions have been previously implicated in substance use disorders for their role in salience, interoception and executive processes. These findings show that those who have a rise in cortisol following smoking cue exposure also have a related rise in cue-induced brain reactivity, in brain regions previously linked with heightened relapse vulnerability. This is clinically relevant as measuring cue-induced cortisol responses is a more accessible proxy for assessing the engagement of cue-induced neurobiological processes associated with the maintenance of nicotine dependence.

Titel:	Brain and cortisol responses to smoking cues are linked in tobacco-smoking individuals.
Autor/in / Beteiligte Person:	Wanger, TJ ; de Moura FB ; Ashare, R ; Loughead, J ; Lukas, S ; Lerman, C ; Janes, AC
Link:	Full Text Finder (Volltext)
Zeitschrift:	Addiction biology, Jg. 28 (2023-12-01), Heft 12, S. e13338
Veröffentlichung:	Hoboken, NJ : Wiley-Blackwell ; <i>Original Publication</i>: Abingdon, Oxfordshire, UK ; Cambridge, MA : Carfax, c1996-, 2023
Medientyp:	academicJournal
ISSN:	1369-1600 (electronic)
DOI:	10.1111/adb.13338
Schlagwort:	Humans Brain diagnostic imaging Magnetic Resonance Imaging methods Nicotine Recurrence Cues Hydrocortisone Smoking
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, N.I.H., Intramural Language: English [Addict Biol] 2023 Dec; Vol. 28 (12), pp. e13338. MeSH Terms: Cues* ; Hydrocortisone* ; Smoking* ; Humans ; Brain / diagnostic imaging ; Magnetic Resonance Imaging / methods ; Nicotine ; Recurrence References: West R, Hajek P, Stead L, Stapleton J. Outcome criteria in smoking cessation trials: proposal for a common standard. Addiction. 2005;100(3):299-303. doi:10.1111/j.1360-0443.2004.00995.x. ; Shiffman S, Paty JA, Gnys M, Kassel JA, Hickcox M. First lapses to smoking: within-subjects analysis of real-time reports. J Consult Clin Psychol. 1996;64(2):366-379. doi:10.1037/0022-006X.64.2.366. ; Ferguson SG, Shiffman S. The relevance and treatment of cue-induced cravings in tobacco dependence. J Subst Abuse Treat. 2009;36(3):235-243. doi:10.1016/j.jsat.2008.06.005. ; Janes AC, Pizzagalli DA, Richardt S, et al. 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Proc Natl Acad Sci. 2016;113(28):7900-7905. doi:10.1073/pnas.1602413113. Grant Information: 5K02DA042987 United States DA NIDA NIH HHS; 5R01DA039135 United States DA NIDA NIH HHS; T32DA015036 United States DA NIDA NIH HHS Contributed Indexing: Keywords: cortisol; cue reactivity; insula Substance Nomenclature: WI4X0X7BPJ (Hydrocortisone) ; 6M3C89ZY6R (Nicotine) Entry Date(s): Date Created: 20231129 Date Completed: 20231130 Latest Revision: 20240311 Update Code: 20240312

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Brain and cortisol responses to smoking cues are linked in tobacco-smoking individuals.