Diversity of HLA-A, -B, -C, -DRB1, and -DQB1 alleles and haplotypes in Kazakhstani Tatar population and genetic relatedness to other populations.

Hajjej, A ; Abdrakhmanova, S ; et al.

In: Gene, Jg. 896 (2024-02-20), S. 148062

academicJournal

Background: Kazakhstan is a transcontinental former Soviet Union republic whose present-day population comprises more than 100 ethnic groups. Insofar as Human Leukocyte Antigen (HLA) genotyping is useful for anthropological studies, data on the HLA profile of Kazakhstani Tatars are lacking.

Objective: We extend our earlier findings on the unique HLA profile of distinct Kazakhstani populations by examining HLA class I and class II loci in Kazakhstani (Volga) Tatar minority population and its relatedness to those of bordering and worldwide communities.

Methods: HLA class I and class II genotypes of the Kazakhstan Tatar minority were analyzed by PCR-SSP and were compared to neighboring populations using Neighbor-Joining (NJ) trees and standard genetic distances (SGD) analysis.

Results: In total, 132 HLA alleles were identified in a sample of 103 Kazakhstani Tatars, of which HLA-A*02:01 (20.1 %), -B*07:02 (12.1 %), -C*07:02 (12.7 %), -DRB1*07:01 (18.1 %), and -DQB1*02:01 (19.6 %) were the most frequent. The most frequent two-locus haplotypes were B*07:02 ∼ C*07:02 (10.6 %) B*07:02 ∼ DRB1*15:01 (06.1 %), B*07:02 ∼ DQB1*06:02 (07.1 %), and DRB1*15:01 ∼ DQB1*06:02 (11.6 %).

Conclusions: Considering historical data, the close relatedness of Kazakhstani Tatars to European Russians (including Russian Tatars) suggests that Kazakhstani Tatars may be Russian Tatars, who originated from the Volga region, following their massive migrations to central Asia.

Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Titel:	Diversity of HLA-A, -B, -C, -DRB1, and -DQB1 alleles and haplotypes in Kazakhstani Tatar population and genetic relatedness to other populations.
Autor/in / Beteiligte Person:	Hajjej, A ; Abdrakhmanova, S ; Turganbekova, A ; Almawi, WY
Zeitschrift:	Gene, Jg. 896 (2024-02-20), S. 148062
Veröffentlichung:	Amsterdam, Elsevier/North-Holland, 1976-, 2024
Medientyp:	academicJournal
ISSN:	1879-0038 (electronic)
DOI:	10.1016/j.gene.2023.148062
Schlagwort:	Humans Haplotypes Gene Frequency Alleles HLA-DQ beta-Chains genetics HLA-DRB1 Chains genetics HLA-A Antigens genetics Histocompatibility Antigens Class I genetics Eastern European People
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Gene] 2024 Feb 20; Vol. 896, pp. 148062. <i>Date of Electronic Publication: </i>2023 Dec 02. MeSH Terms: HLA-A Antigens* / genetics ; Histocompatibility Antigens Class I* / genetics ; Eastern European People* ; Humans ; Haplotypes ; Gene Frequency ; Alleles ; HLA-DQ beta-Chains / genetics ; HLA-DRB1 Chains / genetics Contributed Indexing: Keywords: Genotypes; HLA; Haplotypes; Kazakhstan; Russia; Tatar Substance Nomenclature: 0 (HLA-DQ beta-Chains) ; 0 (HLA-DRB1 Chains) ; 0 (HLA-A Antigens) ; 0 (Histocompatibility Antigens Class I) Entry Date(s): Date Created: 20231204 Date Completed: 20240112 Latest Revision: 20240112 Update Code: 20240112

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