Longitudinal Assessment of Pancreas Volume by MRI Predicts Progression to Stage 3 Type 1 Diabetes.
In: Diabetes care, Jg. 47 (2024-03-01), Heft 3, S. 393-400
academicJournal
Zugriff:
Objective: This multicenter prospective cohort study compared pancreas volume as assessed by MRI, metabolic scores derived from oral glucose tolerance testing (OGTT), and a combination of pancreas volume and metabolic scores for predicting progression to stage 3 type 1 diabetes (T1D) in individuals with multiple diabetes-related autoantibodies.
Research Design and Methods: Pancreas MRI was performed in 65 multiple autoantibody-positive participants enrolled in the Type 1 Diabetes TrialNet Pathway to Prevention study. Prediction of progression to stage 3 T1D was assessed using pancreas volume index (PVI), OGTT-derived Index60 score and Diabetes Prevention Trial-Type 1 Risk Score (DPTRS), and a combination of PVI and DPTRS.
Results: PVI, Index60, and DPTRS were all significantly different at study entry in 11 individuals who subsequently experienced progression to stage 3 T1D compared with 54 participants who did not experience progression (P < 0.005). PVI did not correlate with metabolic testing across individual study participants. PVI declined longitudinally in the 11 individuals diagnosed with stage 3 T1D, whereas Index60 and DPTRS increased. The area under the receiver operating characteristic curve for predicting progression to stage 3 from measurements at study entry was 0.76 for PVI, 0.79 for Index60, 0.79 for DPTRS, and 0.91 for PVI plus DPTRS.
Conclusions: These findings suggest that measures of pancreas volume and metabolism reflect distinct components of risk for developing stage 3 type 1 diabetes and that a combination of these measures may provide superior prediction than either alone.
(© 2024 by the American Diabetes Association.)
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Longitudinal Assessment of Pancreas Volume by MRI Predicts Progression to Stage 3 Type 1 Diabetes.
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Autor/in / Beteiligte Person: | Virostko, J ; Wright, JJ ; Williams, JM ; Hilmes, MA ; Triolo, TM ; Broncucia, H ; Du, L ; Kang, H ; Nallaparaju, S ; Valencia, LG ; Reyes, D ; Hammel, B ; Russell, WE ; Philipson, LH ; Waibel, M ; Kay, TWH ; Thomas, HE ; Greeley, SAW ; Steck, AK ; Powers, AC ; Moore, DJ |
Zeitschrift: | Diabetes care, Jg. 47 (2024-03-01), Heft 3, S. 393-400 |
Veröffentlichung: | Alexandria Va : American Diabetes Association ; <i>Original Publication</i>: New York, American Diabetes Assn., 2024 |
Medientyp: | academicJournal |
ISSN: | 1935-5548 (electronic) |
DOI: | 10.2337/dc23-1681 |
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