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Purpose: Tensor-valued diffusion encoding can disentangle orientation dispersion and subvoxel anisotropy, potentially offering insight into microstructural changes after cerebral ischemia. The purpose was to evaluate tensor-valued diffusion MRI in human acute ischemic stroke, assess potential confounders from diffusion time dependencies, and compare to Monte Carlo diffusion simulations of axon beading.

Methods: Linear (LTE) and spherical (STE) b-tensor encoding with inherently different effective diffusion times were acquired in 21 acute ischemic stroke patients between 3 and 57 h post-onset at 3 T in 2.5 min. In an additional 10 patients, STE with 2 LTE yielding different effective diffusion times were acquired for comparison. Diffusional variance decomposition (DIVIDE) was used to estimate microscopic anisotropy (μFA), as well as anisotropic, isotropic, and total diffusional variance (MK A , MK I , MK T ). DIVIDE parameters, and diffusion tensor imaging (DTI)-derived mean diffusivity and fractional anisotropy (FA) were compared in lesion versus contralateral white matter. Monte Carlo diffusion simulations of various cylindrical geometries for all b-tensor protocols were used to interpret parameter measurements.

Results: MD was ˜40% lower in lesions for all LTE/STE protocols. The DIVIDE parameters varied with effective diffusion time: higher μFA and MK A in lesion versus contralateral white matter for STE with longer effective diffusion time LTE, whereas the shorter effective diffusion time LTE protocol yielded lower μFA and MK A in lesions. Both protocols, regardless of diffusion time, were consistent with simulations of greater beading amplitude and intracellular volume fraction.

Conclusion: DIVIDE parameters depend on diffusion time in acute stroke but consistently indicate neurite beading and larger intracellular volume fraction.

Titel:	Tensor-valued diffusion MRI of human acute stroke.
Autor/in / Beteiligte Person:	Zhou, M ; Stobbe, R ; Szczepankiewicz, F ; Budde, M ; Buck, B ; Kate, M ; Lloret, M ; Fairall, P ; Butcher, K ; Shuaib, A ; Emery, D ; Nilsson, M ; Westin, CF ; Beaulieu, C
Link:	Full Text Finder (Volltext)
Zeitschrift:	Magnetic resonance in medicine, Jg. 91 (2024-05-01), Heft 5, S. 2126-2141
Veröffentlichung:	1999- : New York, NY : Wiley ; <i>Original Publication</i>: San Diego : Academic Press,, 2024
Medientyp:	academicJournal
ISSN:	1522-2594 (electronic)
DOI:	10.1002/mrm.29975
Schlagwort:	Humans Diffusion Tensor Imaging methods Diffusion Magnetic Resonance Imaging methods Anisotropy Brain diagnostic imaging Brain pathology Ischemic Stroke pathology White Matter pathology Stroke diagnostic imaging
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Magn Reson Med] 2024 May; Vol. 91 (5), pp. 2126-2141. <i>Date of Electronic Publication: </i>2023 Dec 29. MeSH Terms: Ischemic Stroke* / pathology ; White Matter* / pathology ; Stroke* / diagnostic imaging ; Humans ; Diffusion Tensor Imaging / methods ; Diffusion Magnetic Resonance Imaging / methods ; Anisotropy ; Brain / diagnostic imaging ; Brain / pathology References: Moseley ME, Cohen Y, Mintorovitch J, et al. Early detection of regional cerebral ischemia in cats: comparison of diffusion-and T2-weighted MRI and spectroscopy. Magn Reson Med. 1990;14:330-346. ; Budde MD, Frank JA. Neurite beading is sufficient to decrease the apparent diffusion coefficient after ischemic stroke. Proc Natl Acad Sci U S A. 2010;107:14472-14477. ; Skinner NP, Kurpad SN, Schmit BD, Budde MD. 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Tensor-valued diffusion MRI of human acute stroke.