Einzeltreffer — DigiBib

MeCP2 is a general regulator of transcription involved in the repression/activation of genes depending on the local epigenetic context. It acts as a chromatin regulator and binds with exquisite specificity to gene promoters. The set of epigenetic marks recognized by MeCP2 has been already established (mainly, cytosine modifications in CpG and CpA), as well as many of the constituents of its interactome. We unveil a new set of interactions for MeCP2 with the four canonical nucleosomal histones. MeCP2 interacts with high affinity with H2A, H2B, H3 and H4. In addition, Rett syndrome associated mutations in MeCP2 and histone epigenetic marks modulate these interactions. Given the abundance and the structural/functional relevance of histones and their involvement in epigenetic regulation, this new set of interactions and its modulating elements provide a new addition to the 'alphabet' for this epigenetic reader.

Titel:	Extending MeCP2 interactome: canonical nucleosomal histones interact with MeCP2.
Autor/in / Beteiligte Person:	Ortega-Alarcon, D ; Claveria-Gimeno, R ; Vega, S ; Kalani, L ; Jorge-Torres, OC ; Esteller, M ; Ausio, J ; Abian, O ; Velazquez-Campoy, A
Link:	Full Text Finder (Volltext)
Zeitschrift:	Nucleic acids research, Jg. 52 (2024-04-24), Heft 7, S. 3636-3653
Veröffentlichung:	1992- : Oxford : Oxford University Press ; <i>Original Publication</i>: London, Information Retrieval ltd., 2024
Medientyp:	academicJournal
ISSN:	1362-4962 (electronic)
DOI:	10.1093/nar/gkae051
Schlagwort:	Humans Protein Binding Rett Syndrome genetics Rett Syndrome metabolism Mutation Animals Methyl-CpG-Binding Protein 2 metabolism Methyl-CpG-Binding Protein 2 genetics Nucleosomes metabolism Histones metabolism Epigenesis, Genetic
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Nucleic Acids Res] 2024 Apr 24; Vol. 52 (7), pp. 3636-3653. MeSH Terms: Methyl-CpG-Binding Protein 2* / metabolism ; Methyl-CpG-Binding Protein 2* / genetics ; Nucleosomes* / metabolism ; Histones* / metabolism ; Epigenesis, Genetic* ; Humans ; Protein Binding ; Rett Syndrome / genetics ; Rett Syndrome / metabolism ; Mutation ; Animals References: Biochemistry. 2010 May 25;49(20):4395-410. (PMID: 20405910) ; Mol Cell Biol. 2014 Oct 1;34(19):3662-74. (PMID: 25047840) ; Mol Cell. 2012 Nov 30;48(4):491-507. (PMID: 23200123) ; Neuron. 2011 Oct 6;72(1):72-85. (PMID: 21982370) ; Int J Biol Macromol. 2021 Apr 1;175:58-66. (PMID: 33548325) ; Nat Neurosci. 2018 Jun;21(6):794-798. (PMID: 29802390) ; Trends Biochem Sci. 2006 Feb;31(2):89-97. (PMID: 16403636) ; Methods Mol Biol. 2017;1528:75-95. (PMID: 27854017) ; Nature. 2017 Oct 19;550(7676):398-401. 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(PMID: 12473678) Grant Information: BFU2016-78232-P Ministerio de Economía y Competitividad; Ministerio de Ciencia e Innovación; PID2021-127296OB-I00 ERDF A way of Making Europe; ERDF/ESF Fondo de Investigaciones Sanitarias from Instituto de Salud Carlos III and European Union; PRTR-C17.I1 Spanish Ministry of Science and Innovation; Autonomous Community of Aragón; E45_23R Gobierno de Aragón; Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas Substance Nomenclature: 0 (Methyl-CpG-Binding Protein 2) ; 0 (Nucleosomes) ; 0 (Histones) ; 0 (MECP2 protein, human) Entry Date(s): Date Created: 20240207 Date Completed: 20240424 Latest Revision: 20240426 Update Code: 20240426 PubMed Central ID: PMC11039998

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Extending MeCP2 interactome: canonical nucleosomal histones interact with MeCP2.