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Study Design: Systematic review.

Objectives: The study's primary objective was to determine how osteobiologic choice affects fusion rates in patients undergoing anterior cervical discectomy and fusion (ACDF). The study's secondary objectives were to 1) determine the optimal timing of fusion assessment following ACDF and 2) determine if osteobiologic type affects the timing and optimal modality of fusion assessment.

Methods: A systematic search of PubMed/MEDLINE was conducted for literature published from 2000 through October 2020 comparing anterior fusion in the cervical spine with various osteobiologics. Both comparative studies and case series of ≥10 patients were included.

Results: A total of 74 studies met the inclusion criteria. Seventeen studies evaluated the efficacy of autograft on fusion outcomes, and 23 studies assessed the efficacy of allograft on fusion outcomes. 3 studies evaluated the efficacy of demineralized bone matrix, and seven assessed the efficacy of rhBMP-2 on fusion outcomes. Other limited studies evaluated the efficacy of ceramics and bioactive glasses on fusion outcomes, and 4 assessed the efficacy of stem cell products. Most studies utilized dynamic radiographs for the assessment of fusion. Overall, there was a general lack of supportive data to determine the optimal timing of fusion assessment meaningfully or if osteobiologic type influenced fusion timing.

Conclusions: Achieving fusion following ACDF appears to remain an intricate interplay between host biology and various surgical factors, including the selection of osteobiologics. While alternative osteobiologics to autograft exist and may produce acceptable fusion rates, limitations in study methodology prevent any definitive conclusions from existing literature.

Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Titel:	Comparison of Different Osteobiologics in Terms of Imaging Modalities and Time Frames for Fusion Assessment in Anterior Cervical Discectomy and Fusion: A Systematic Review.
Autor/in / Beteiligte Person:	Chung, AS ; Ravinsky, R ; Kulkarni, R ; Hsieh, PC ; Arts, JJ ; Rodrigues-Pinto, R ; Wang, JC ; Meisel, HJ ; Buser, Z
Link:	Full Text Finder (Volltext)
Zeitschrift:	Global spine journal, Jg. 14 (2024-02-01), Heft 2_suppl, S. 141S-162S
Veröffentlichung:	2017- : London : SAGE Publications ; <i>Original Publication</i>: New York, NY : Thieme Medical Publishers, 2024
Medientyp:	academicJournal
ISSN:	2192-5682 (print)
DOI:	10.1177/21925682231157312
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Corporate Authors: AO Spine Knowledge Forum Degenerative Publication Type: Journal Article Language: English [Global Spine J] 2024 Feb; Vol. 14 (2_suppl), pp. 141S-162S. References: Global Spine J. 2016 Mar;6(2):186-94. (PMID: 26933621) ; Clin Spine Surg. 2017 Feb;30(1):38-46. (PMID: 28107234) ; Neurosurg Focus. 2002 Jan 15;12(1):E2. (PMID: 16212329) ; Spine (Phila Pa 1976). 2009 Dec 1;34(25):2769-74. (PMID: 19940735) ; Neurol Med Chir (Tokyo). 2013;53(2):85-90. (PMID: 23438658) ; Spine (Phila Pa 1976). 2014 Oct 15;39(22):E1331-7. (PMID: 25188591) ; Spine (Phila Pa 1976). 1997 Jul 15;22(14):1585-9. (PMID: 9253093) ; Chang Gung Med J. 2009 Jul-Aug;32(4):447-54. (PMID: 19664352) ; Neurosurgery. 2002 Feb;50(2):229-36; discussion 236-8. (PMID: 11844257) ; Spine (Phila Pa 1976). 2019 Mar 15;44(6):384-388. (PMID: 30180149) ; J Clin Neurosci. 2006 Feb;13(2):181-7. (PMID: 16459086) ; Spine J. 2008 May-Jun;8(3):426-35. (PMID: 17977799) ; Eur Spine J. 2008 May;17(5):698-705. (PMID: 18301927) ; Spine (Phila Pa 1976). 2000 Jan;25(1):41-5. (PMID: 10647159) ; J Neurosurg Spine. 2013 Jan;18(1):43-9. (PMID: 23157278) ; Medicine (Baltimore). 2017 Aug;96(33):e7803. (PMID: 28816974) ; Spine (Phila Pa 1976). 2007 Dec 15;32(26):2980-4. (PMID: 18091490) ; Medicine (Baltimore). 2019 Nov;98(45):e17935. (PMID: 31702680) ; World Neurosurg. 2018 Jan;109:e233-e243. (PMID: 28986227) ; J Neurosurg Spine. 2006 Jan;4(1):1-9. (PMID: 16506459) ; ANZ J Surg. 2003 Sep;73(9):712-6. (PMID: 12956787) ; Spine J. 2003 Nov-Dec;3(6):451-9. (PMID: 14609689) ; World Neurosurg. 2020 Feb;134:272-279. (PMID: 31669245) ; Zentralbl Neurochir. 2006 Feb;67(1):8-13. (PMID: 16518745) ; Spine J. 2001 Sep-Oct;1(5):348-57. (PMID: 14588314) ; Spine J. 2015 Sep 1;15(9):2016-27. (PMID: 25982430) ; Spine (Phila Pa 1976). 2014 Sep 15;39(20):1718-24. (PMID: 24979140) ; J Neurosurg Spine. 2009 Aug;11(2):228-37. (PMID: 19769502) ; Eur Spine J. 2009 Feb;18(2):238-43. (PMID: 19130094) ; Acta Neurochir (Wien). 2011 Mar;153(3):559-65. (PMID: 21132445) ; Spine (Phila Pa 1976). 2011 Nov 1;36(23):E1509-14. (PMID: 21221053) ; Asian Spine J. 2011 Sep;5(3):169-75. (PMID: 21892389) ; Clin Orthop Relat Res. 2005 Jan;(430):108-16. (PMID: 15662311) ; Neurosurg Rev. 2016 Jul;39(3):475-82. (PMID: 27098659) ; Spine (Phila Pa 1976). 2005 Oct 1;30(19):2138-44. (PMID: 16205338) ; Clin Spine Surg. 2017 Nov;30(9):E1321-E1332. (PMID: 27352370) ; J Bone Joint Surg Br. 2003 Sep;85(7):1019-25. (PMID: 14516039) ; Neurosurgery. 2013 Feb;72(2):257-65; discussion 266. (PMID: 23149973) ; Surg Neurol. 2004 Nov;62(5):378-85, discussion 385-6. (PMID: 15518835) ; Spine (Phila Pa 1976). 2012 Sep 1;37(19):1645-51. (PMID: 22433506) ; J Neurosurg Spine. 2013 Nov;19(5):527-31. (PMID: 23992432) ; Spine (Phila Pa 1976). 2006 Mar 1;31(5):542-7. (PMID: 16508549) ; Spine (Phila Pa 1976). 2002 Aug 15;27(16):1694-701. (PMID: 12195057) ; Neurosurg Rev. 2004 Jan;27(1):34-41. (PMID: 12905078) ; Spine J. 2016 Nov;16(11):1367-1376. (PMID: 27498334) ; J Neurosurg Spine. 2011 Feb;14(2):244-9. (PMID: 21184639) ; Transplant Proc. 2013 Jan-Feb;45(1):434-9. (PMID: 23375334) ; Spine (Phila Pa 1976). 1994 Oct 15;19(20):2348-57. (PMID: 7531370) ; J Orthop Traumatol. 2011 Dec;12(4):201-5. (PMID: 22089645) ; Spine (Phila Pa 1976). 1991 Jul;16(7):726-9. (PMID: 1925745) ; Neurosurgery. 2004 Jun;54(6):1405-11; discussion 1411-2. (PMID: 15157297) ; J Spinal Disord Tech. 2013 Jul;26(5):239-45. (PMID: 22198323) ; Spine (Phila Pa 1976). 2018 Jan 1;43(1):E23-E28. (PMID: 28146025) ; Neurosurgery. 2018 Sep 1;83(3):377-384. (PMID: 28945914) ; Cureus. 2018 May 16;10(5):e2636. (PMID: 30034958) ; J Neurol Surg A Cent Eur Neurosurg. 2015 Jul;76(4):268-73. (PMID: 26140339) ; Surg Neurol. 2005 Jun;63(6):497-503; discussion 503-4. (PMID: 15936361) ; J Orthop Surg Res. 2017 Apr 26;12(1):67. (PMID: 28446192) ; Neurosurg Focus. 2002 Jan 15;12(1):E4. (PMID: 16212331) ; Neurosurgery. 2004 Mar;54(3):631-5; discussion 635. (PMID: 15028137) ; Eur Spine J. 2016 Jul;25(7):2233-8. (PMID: 26849141) ; Spine (Phila Pa 1976). 2001 Mar 15;26(6):643-6; discussion 646-7. (PMID: 11246376) ; J Neurosurg Spine. 2005 May;2(5):521-5. (PMID: 15945426) ; Neurosurgery. 2007 Jul;61(1):107-16; discussion 116-7. (PMID: 17621025) ; Materials (Basel). 2018 Dec 12;11(12):. (PMID: 30545136) ; Spine J. 2019 Mar;19(3):469-475. (PMID: 29990594) ; Acta Neurochir (Wien). 2011 Jan;153(1):115-22. (PMID: 20924769) ; Spine (Phila Pa 1976). 2003 Feb 15;28(4):317-23. (PMID: 12590203) ; J Neurosurg. 2002 Apr;96(3 Suppl):273-6. (PMID: 11990834) ; Eur Spine J. 2000 Oct;9(5):398-403. (PMID: 11057533) ; Spine (Phila Pa 1976). 1989 Dec;14(12):1324-31. (PMID: 2617362) ; Medicine (Baltimore). 2019 Aug;98(32):e16621. (PMID: 31393360) ; Eur Spine J. 2004 Oct;13(6):510-5. (PMID: 15042453) ; Med Sci Monit. 2015 Oct 19;21:3159-65. (PMID: 26479708) ; Korean J Spine. 2012 Sep;9(3):142-6. (PMID: 25983805) ; J Neurosurg Spine. 2007 Jan;6(1):10-6. (PMID: 17233285) ; Spine (Phila Pa 1976). 2009 Aug 1;34(17):E591-5. (PMID: 19644317) ; Eur Spine J. 2007 Aug;16(8):1257-65. (PMID: 17387522) ; Global Spine J. 2017 Feb;7(1):59-70. (PMID: 28451511) ; Clin Neurol Neurosurg. 2017 Apr;155:30-35. (PMID: 28242558) ; Eur Spine J. 2006 Feb;15(2):157-64. (PMID: 15980998) ; Spine (Phila Pa 1976). 2020 Jul 1;45(13):E776-E780. (PMID: 32080012) ; Spine (Phila Pa 1976). 2012 Sep 15;37(20):1734-41. (PMID: 22466632) ; J Neurosurg Spine. 2015 Jan;22(1):1-10. (PMID: 25360528) ; World Neurosurg. 2020 Jan;133:e592-e599. (PMID: 31568900) ; Eur Spine J. 2017 Sep;26(9):2372-2379. (PMID: 28382392) ; Spine (Phila Pa 1976). 2005 Aug 1;30(15):1756-61. (PMID: 16094278) ; Spine (Phila Pa 1976). 2003 Jun 15;28(12):1219-24; discussion 1225. (PMID: 12811263) ; J Neurosurg Spine. 2006 Apr;4(4):292-9. (PMID: 16619675) ; Spine (Phila Pa 1976). 1992 Dec;17(12):1474-80. (PMID: 1471005) ; Spine (Phila Pa 1976). 2000 Aug 1;25(15):1908-16. (PMID: 10908933) Contributed Indexing: Keywords: allograft; autograft; bone morphogenetic protein; ceramics; cervical fusion; fusion; osteobiologics Entry Date(s): Date Created: 20240229 Latest Revision: 20240307 Update Code: 20240307 PubMed Central ID: PMC10913913

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Comparison of Different Osteobiologics in Terms of Imaging Modalities and Time Frames for Fusion Assessment in Anterior Cervical Discectomy and Fusion: A Systematic Review.