Einzeltreffer — DigiBib

Acquired traumatic central nervous system (CNS) injuries, including traumatic brain injury (TBI) and spinal cord injury (SCI), are devastating conditions with limited treatment options. Neuroinflammation plays a pivotal role in secondary damage, making it a prime target for therapeutic intervention. Emerging therapeutic strategies are designed to modulate the inflammatory response, ultimately promoting neuroprotection and neuroregeneration. The use of anti-inflammatory agents has yielded limited support in improving outcomes in patients, creating a critical need to re-envision novel approaches to both quell deleterious inflammatory processes and upend the progressive cycle of neurotoxic inflammation. This demands a comprehensive exploration of individual, age, and sex differences, including the use of advanced imaging techniques, multi-omic profiling, and the expansion of translational studies from rodents to humans. Moreover, a holistic approach that combines pharmacological intervention with multidisciplinary neurorehabilitation is crucial and must include both acute and long-term care for the physical, cognitive, and emotional aspects of recovery. Ongoing research into neuroinflammatory biomarkers could revolutionize our ability to predict, diagnose, and monitor the inflammatory response in real time, allowing for timely adjustments in treatment regimens and facilitating a more precise evaluation of therapeutic efficacy. The management of neuroinflammation in acquired traumatic CNS injuries necessitates a paradigm shift in our approach that includes combining multiple therapeutic modalities and fostering a more comprehensive understanding of the intricate neuroinflammatory processes at play.

Competing Interests: The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Titel:	Neuroinflammation and acquired traumatic CNS injury: a mini review.
Autor/in / Beteiligte Person:	Theus, MH
Link:	Full Text Finder (Volltext)
Zeitschrift:	Frontiers in neurology, Jg. 15 (2024-02-21), S. 1334847
Veröffentlichung:	[Lausanne : Frontiers Research Foundation, 2010]-, 2024
Medientyp:	academicJournal
ISSN:	1664-2295 (print)
DOI:	10.3389/fneur.2024.1334847
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Review Language: English [Front Neurol] 2024 Feb 21; Vol. 15, pp. 1334847. <i>Date of Electronic Publication: </i>2024 Feb 21 (<i>Print Publication: </i>2024). References: Biomedicines. 2020 Sep 29;8(10):. (PMID: 33003373) ; J Neurosci. 2018 Nov 7;38(45):9618-9634. (PMID: 30242049) ; Transl Psychiatry. 2023 Jan 9;13(1):5. (PMID: 36624089) ; Mil Med. 2015 Apr;180(4):380-6. (PMID: 25826342) ; Nat Commun. 2020 Mar 5;11(1):1220. (PMID: 32139688) ; Med Res Rev. 2021 May;41(3):1427-1473. (PMID: 33295676) ; Rehabil Psychol. 2009 Aug;54(3):239-246. (PMID: 19702422) ; Brain Circ. 2017 Jul-Sep;3(3):135-142. (PMID: 30276315) ; Cells. 2021 Jul 29;10(8):. (PMID: 34440700) ; Front Physiol. 2021 Oct 22;12:740939. (PMID: 34744783) ; Neurotherapeutics. 2015 Oct;12(4):896-909. (PMID: 26306439) ; Brain Res. 2015 Oct 14;1623:63-73. (PMID: 25813828) ; Front Aging Neurosci. 2022 Mar 25;14:825086. (PMID: 35401152) ; Nat Rev Neurol. 2017 Sep;13(9):572. (PMID: 28776601) ; Front Immunol. 2023 Mar 09;14:1127704. (PMID: 36969193) ; Sci Adv. 2020 May 29;6(22):eaax8847. (PMID: 32523980) ; Front Cell Neurosci. 2020 Sep 30;14:576037. (PMID: 33192321) ; J Neurotrauma. 2022 Apr;39(7-8):436-457. (PMID: 35057637) ; Proc Natl Acad Sci U S A. 2023 Feb 7;120(6):e2217868120. (PMID: 36719923) ; Front Immunol. 2020 Jul 08;11:1024. (PMID: 32733433) ; Acta Neurochir (Wien). 2021 Sep;163(9):2581-2594. (PMID: 34273044) ; JOR Spine. 2019 Mar 05;2(1):e1044. (PMID: 31463458) ; Immunity. 2021 Feb 9;54(2):211-224. (PMID: 33567261) ; Nat Rev Immunol. 2018 Feb;18(2):134-147. (PMID: 28990587) ; Neurol Neuroimmunol Neuroinflamm. 2023 Jun 29;10(5):. (PMID: 37385738) ; J Neuroinflammation. 2014 Jun 03;11:98. (PMID: 24889886) ; Brain Behav Immun. 2018 Jan;67:1-12. (PMID: 28216088) ; Int J Mol Sci. 2022 Jun 11;23(12):. (PMID: 35742984) ; Int J Mol Sci. 2022 May 20;23(10):. (PMID: 35628553) ; Nat Immunol. 2019 May;20(5):559-570. (PMID: 30996332) ; Physiol Rev. 2018 Jan 1;98(1):477-504. (PMID: 29351513) ; Lancet Neurol. 2019 Jan;18(1):24-25. (PMID: 30497967) ; Commun Biol. 2020 Jun 12;3(1):305. (PMID: 32533056) ; J Neurochem. 2016 Oct;139 Suppl 2:136-153. (PMID: 26990767) ; Int J Mol Sci. 2020 Oct 13;21(20):. (PMID: 33066029) ; Front Immunol. 2020 Jul 16;11:1416. (PMID: 32765501) ; Cells. 2022 Oct 25;11(21):. (PMID: 36359758) ; J Neuroinflammation. 2023 Sep 30;20(1):222. (PMID: 37777772) ; J Neuropathol Exp Neurol. 2011 Mar;70(3):167-76. (PMID: 21293295) ; Glia. 2019 Jun;67(6):1017-1035. (PMID: 30548343) ; Nat Rev Neurosci. 2018 Oct;19(10):622-635. (PMID: 30206328) ; Int J Inflam. 2017;2017:8385961. (PMID: 28127491) ; Front Immunol. 2020 Mar 20;11:493. (PMID: 32265936) ; Front Neurol. 2019 Mar 22;10:282. (PMID: 30967837) ; Int J Mol Sci. 2021 Jun 15;22(12):. (PMID: 34203960) ; Signal Transduct Target Ther. 2021 Jun 28;6(1):245. (PMID: 34176928) ; J Neuroinflammation. 2018 Dec 18;15(1):345. (PMID: 30563537) ; Biomedicines. 2021 Jun 10;9(6):. (PMID: 34200905) ; Aging (Albany NY). 2022 Sep 16;14(18):7455-7469. (PMID: 36126193) ; Theranostics. 2017 Aug 23;7(15):3608-3623. (PMID: 29109764) ; BMJ Open. 2023 Oct 6;13(10):e075049. (PMID: 37802626) ; Front Immunol. 2021 Aug 11;12:698249. (PMID: 34456910) ; Cell Mol Immunol. 2020 May;17(5):433-450. (PMID: 32238918) Grant Information: R01 NS112541 United States NS NINDS NIH HHS; R01 NS119540 United States NS NINDS NIH HHS; R01 NS121103 United States NS NINDS NIH HHS Contributed Indexing: Keywords: Neurotoxic injury; glia; immunometabolism; inflammation; peripheral immune cells; phenotypic plasticity; spinal cord injury; traumatic brain injury Entry Date(s): Date Created: 20240307 Latest Revision: 20240309 Update Code: 20240309 PubMed Central ID: PMC10915049

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Neuroinflammation and acquired traumatic CNS injury: a mini review.