Einzeltreffer — DigiBib

Purpose: To analyze the radiological features of the lacrimal gland (LG) and extraocular muscle (EOM) in thyroid eye disease (TED) patients with severe subjective dry eye disease (DED) using magnetic resonance imaging (MRI) measurements.

Methods: In this cross-sectional study, mechanical ocular exposure, dry eye assessment and MRI data were collected. Patients were classified into non-severe subjective DED group with ocular surface disease index (OSDI) < 33 and severe subjective DED group with OSDI ≥ 33. Linear regression model was applied for comparing the OSDI < 33 and OSDI ≥ 33 group in TED patients. The predictive performance of MRI parameters and models was assessed by receiver operating characteristic curve (ROC) analysis.

Results: Consecutive 88 TED patients (176 eyes) were included in this study. In the OSDI < 33 group, 52 TED patients (104 eyes) with a mean clinical activity score (CAS) of 0.63 ± 0.75. In the OSDI ≥ 33 group, there are 36 TED patients (72 eyes), with a mean CAS of 1.50 ± 1.54. The age and sex of the patients were matched between the two groups. The OSDI ≥ 33 group had shorter tear break-up time, larger levator palpebrae superioris / superior rectus (LPS/SR), inferior rectus and lateral rectus, smaller LG, more inflammatory LPS/SR and inferior rectus than OSDI < 33 DED group (P < 0.05). In the linear regression analysis, compare to the OSDI < 33 DED group, the OSDI ≥ 33 group had larger medial rectus cross-sectional area (β = 0.06, 95%CI: (0.02, 0.10), P = 0.008), larger inferior rectus cross-sectional area (β = 0.06, 95%CI: (0.00, 0.12), P = 0.048), smaller LG cross-sectional area (β = -0.14, 95%CI: (-0.25, -0.04), P = 0.008). In the ROC analysis, the area under curve of medial rectus, inferior rectus, LG, and combined model are 0.625, 0.640, 0.661 and 0.716, respectively.

Conclusion: Multiparametric MRI parameters of the LG and EOM in TED patients with severe subjective DED were significantly altered. Novel models combining the cross-sectional area of LG, medial rectus and inferior rectus showed good predictive performance in TED patients with severe subjective DED.

Titel:	Investigation of lacrimal gland and extraocular muscle in thyroid eye disease patients with severe subjective dry eye disease: a multiparametric magnetic resonance imaging study.
Autor/in / Beteiligte Person:	Liao, X ; Aljufairi, FMAA ; Sebastian, JU ; Jia, R ; Wong, HYM ; Lai, KKH ; Chen, W ; Hu, Z ; Wei, Y ; Chu, WCW ; Tham, CCY ; Pang, CP ; Chong, KKL
Link:	View record at Springer (Volltext)
Zeitschrift:	Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2024-03-08
Veröffentlichung:	Ahead of Print, 2024
Medientyp:	academicJournal
ISSN:	1435-702X (electronic)
DOI:	10.1007/s00417-024-06424-x
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Graefes Arch Clin Exp Ophthalmol] 2024 Mar 08. <i>Date of Electronic Publication: </i>2024 Mar 08. References: Bartalena L, Kahaly GJ, Baldeschi L, Dayan CM, Eckstein A, Marcocci C, Marinò M, Vaidya B, Wiersinga WM (2021) The 2021 European Group on Graves’ orbitopathy (EUGOGO) clinical practice guidelines for the medical management of Graves’ orbitopathy. Eur J Endocrinol 185:G43-g67. https://doi.org/10.1530/eje-21-0479. (PMID: 10.1530/eje-21-047934297684) ; Bartley GB, Gorman CA (1995) Diagnostic criteria for Graves’ ophthalmopathy. Am J Ophthalmol 119:792–795. https://doi.org/10.1016/s0002-9394(14)72787-4. (PMID: 10.1016/s0002-9394(14)72787-47785696) ; Rana HS, Akella SS, Clabeaux CE, Skurski ZP, Aakalu VK (2022) Ocular surface disease in thyroid eye disease: a narrative review. Ocul Surf 24:67–73. https://doi.org/10.1016/j.jtos.2022.02.001. (PMID: 10.1016/j.jtos.2022.02.001351679509058200) ; Khong JJ, McNab AA, Ebeling PR, Craig JE, Selva D (2016) Pathogenesis of thyroid eye disease: review and update on molecular mechanisms. Br J Ophthalmol 100:142–150. https://doi.org/10.1136/bjophthalmol-2015-307399. (PMID: 10.1136/bjophthalmol-2015-30739926567024) ; Craig JP, Nichols KK, Akpek EK, Caffery B, Dua HS, Joo CK, Liu Z, Nelson JD, Nichols JJ, Tsubota K, Stapleton F (2017) TFOS DEWS II definition and classification report. Ocul Surf 15:276–283. https://doi.org/10.1016/j.jtos.2017.05.008. (PMID: 10.1016/j.jtos.2017.05.00828736335) ; Tsubota K, Yokoi N, Watanabe H, Dogru M, Kojima T, Yamada M, Kinoshita S, Kim HM, Tchah HW, Hyon JY, Yoon KC, Seo KY, Sun X, Chen W, Liang L, Li M, Tong L, Hu FR, Puangsricharern V, Lim-Bon-Siong R, Yong TK, Liu Z, Shimazaki J (2020) A new perspective on dry eye classification: proposal by the asia dry eye society. Eye Contact Lens 46(Suppl 1):S2-s13. https://doi.org/10.1097/icl.0000000000000643. (PMID: 10.1097/icl.000000000000064331425351) ; Gupta A, Sadeghi PB, Akpek EK (2009) Occult thyroid eye disease in patients presenting with dry eye symptoms. Am J Ophthalmol 147:919–923. https://doi.org/10.1016/j.ajo.2008.12.007. (PMID: 10.1016/j.ajo.2008.12.00719211095) ; Inoue S, Kawashima M, Arita R, Kozaki A, Tsubota K (2020) investigation of meibomian gland function and dry eye disease in patients with graves' ophthalmopathy. J Clin Med 9. https://doi.org/10.3390/jcm9092814. ; Wu D, Zhu H, Hong S, Li B, Zou M, Ma X, Zhao X, Wan P, Yang Z, Li Y, Xiao H (2021) Utility of multi-parametric quantitative magnetic resonance imaging of the lacrimal gland for diagnosing and staging Graves’ ophthalmopathy. Eur J Radiol 141:109815. https://doi.org/10.1016/j.ejrad.2021.109815. (PMID: 10.1016/j.ejrad.2021.10981534130234) ; Jiang M, Song X, Zhang H, Tao X, Yang G, Wang Y, Liu Y, Zhou H, Sun J, Li Y (2022) The combination of T2-mapping value of lacrimal gland and clinical indicators can improve the stage prediction of Graves’ ophthalmopathy compared to clinical activity scores. Endocrine 78:321–328. https://doi.org/10.1007/s12020-022-03167-9. (PMID: 10.1007/s12020-022-03167-935997966) ; Bingham CM, Harris MA, Realini T, Nguyen J, Hogg JP, Sivak-Callcott JA (2014) Calculated computed tomography volumes of lacrimal glands and comparison to clinical findings in patients with thyroid eye disease. Ophthalmic Plast Reconstr Surg 30:116–118. https://doi.org/10.1097/iop.0000000000000015. (PMID: 10.1097/iop.000000000000001524448234) ; Lou L, Yang L, Ye X, Zhu Y, Wang S, Sun L, Qian D, Ye J (2019) A novel approach for automated eyelid measurements in blepharoptosis using digital image analysis. Curr Eye Res 44(10):1075–1079. https://doi.org/10.1080/02713683.2019.1619779. ; Sleep TJ, Manners RMJOP, Surgery R (2002) Interinstrument variability in Hertel-type exophthalmometers. 18:254–257. ; Lelli GJ Jr, Duong JK, Kazim M (2010) Levator excursion as a predictor of both eyelid lag and lagophthalmos in thyroid eye disease. Ophthalmic Plast Reconstr Surg 26(1):7–10. https://doi.org/10.1097/IOP.0b013e3181b8e08d. ; Equiterio BS, Garcia DM, Cruz AA, Rootman DB, Goldberg RA, Sales-Sanz M, Galindo-Ferreiro A, Diniz SJCER (2021) Lid Flare measurement with lateral midpupil distances. 46:1309–1313. ; Amparo F, Schaumberg DA, Dana RJO (2015) Comparison of two questionnaires for dry eye symptom assessment: the ocular surface disease index and the symptom assessment in dry eye. 122:1498–1503. ; Lee R, Yeo S, Aung HT, Tong L (2016) Agreement of noninvasive tear break-up time measurement between Tomey RT-7000 Auto Refractor-Keratometer and Oculus Keratograph 5M. Clin Ophthalmol 10:1785–1790. https://doi.org/10.2147/OPTH.S110180. ; Park J, Kim J, Lee H, Park M, Baek S (2018) Functional and structural evaluation of the meibomian gland using a LipiView interferometer in thyroid eye disease. Can J Ophthalmol 53(4):373–379. https://doi.org/10.1016/j.jcjo.2017.11.006. ; Arita R, Suehiro J, Haraguchi T, Shirakawa R, Tokoro H, Amano S (2014) Objective image analysis of the meibomian gland area. Br J Ophthalmol 98(6):746–55. https://doi.org/10.1136/bjophthalmol-2012-303014. ; Ma R, Geng Y, Gan L, Peng Z, Cheng J, Guo J, Qian J (2022) Quantitative T1 mapping MRI for the assessment of extraocular muscle fibrosis in thyroid-associated ophthalmopathy. Endocrine 75:456–464. https://doi.org/10.1007/s12020-021-02873-0. (PMID: 10.1007/s12020-021-02873-034549377) ; Ugradar S, Zimmerman E, Parunakian E, Kang J, Cockerham K, Douglas RS (2023) Change in lacrimal gland volume and aqueous tear production following treatment with teprotumumab. Clin Exp Ophthalmol. https://doi.org/10.1111/ceo.14208. (PMID: 10.1111/ceo.1420836723406) ; Gagliardo C, Radellini S, MorrealeBubella R, Falanga G, Richiusa P, Vadalà M, Ciresi A, Midiri M, Giordano C (2020) Lacrimal gland herniation in Graves ophthalmopathy: a simple and useful MRI biomarker of disease activity. Eur Radiol 30:2138–2141. https://doi.org/10.1007/s00330-019-06570-5. (PMID: 10.1007/s00330-019-06570-531953667) ; Ishikawa E, Takahashi Y, Valencia MRP, Ana-Magadia MG, Kakizaki H (2019) Asymmetric lacrimal gland enlargement: an indicator for detection of pathological entities other than thyroid eye disease. Graefe's Arch Clin Exp Ophthalmol = Albrecht von Graefes Archiv fur klinische und experimentelle. Ophthalmologie 257:405–411. https://doi.org/10.1007/s00417-018-4197-0. ; Inoue S, Kawashima M, Arita R, Kozaki A, Tsubota KJJoCM (2020) Investigation of meibomian gland function and dry eye disease in patients with Graves’. Ophthalmopathy 9:2814. ; Schlachter, Dianne, Evan H. Black, and Geoffrey J (2018) Gladstone. "Eyelid retraction and lagophthalmos." Oculoplastic Surgery Atlas: Eyelid and Lacrimal Disorders: 27–37. https://link.springer.com/chapter/10.1007/978-3-319-67334-9_4. ; Gao Y, Chang Q, Li Y, Zhang H, Hou Z, Zhang Z, Li Z, Li D (2022) Correlation between extent of lacrimal gland prolapse and clinical features of thyroid-associated ophthalmopathy: a retrospective observational study. BMC Ophthalmol 22:66. https://doi.org/10.1186/s12886-022-02270-9. (PMID: 10.1186/s12886-022-02270-9351445798832675) ; Chen L, Hu H, Chen W, Wu Q, Zhou J, Chen HH, Xu XQ, Shi HB, Wu FY (2021) Usefulness of readout-segmented EPI-based diffusion tensor imaging of lacrimal gland for detection and disease staging in thyroid-associated ophthalmopathy. BMC Ophthalmol 21:281. https://doi.org/10.1186/s12886-021-02044-9. (PMID: 10.1186/s12886-021-02044-9342847408290601) ; Hu H, Xu XQ, Chen L, Chen W, Wu Q, Chen HH, Zhu H, Shi HB, Wu FY (2020) Predicting the response to glucocorticoid therapy in thyroid-associated ophthalmopathy: mobilizing structural MRI-based quantitative measurements of orbital tissues. Endocrine 70:372–379. https://doi.org/10.1007/s12020-020-02367-5. (PMID: 10.1007/s12020-020-02367-532504380) ; Byun JS, Moon NJ, Lee JK (2017) Quantitative analysis of orbital soft tissues on computed tomography to assess the activity of thyroid-associated orbitopathy. Graefe's Arch Clin Exp Ophthalmol = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 255:413–420. https://doi.org/10.1007/s00417-016-3538-0. ; Hu H, Xu XQ, Wu FY, Chen HH, Su GY, Shen J, Hong XN, Shi HB (2016) Diagnosis and stage of Graves’ ophthalmopathy: Efficacy of quantitative measurements of the lacrimal gland based on 3-T magnetic resonance imaging. Exp Ther Med 12:725–729. https://doi.org/10.3892/etm.2016.3389. (PMID: 10.3892/etm.2016.3389274462674950689) ; Harris MA, Realini T, Hogg JP, Sivak-Callcott JA (2012) CT dimensions of the lacrimal gland in Graves orbitopathy. Ophthalmic Plast Reconstr Surg 28:69–72. https://doi.org/10.1097/IOP.0b013e31823c4a3a. (PMID: 10.1097/IOP.0b013e31823c4a3a22262292) Grant Information: Project no. 2191216 S.K. Yee Medical Foundation Contributed Indexing: Keywords: Dry Eye Disease; Extraocular Muscle; Lacrimal Gland; MRI; Thyroid Eye Disease Entry Date(s): Date Created: 20240308 Latest Revision: 20240308 Update Code: 20240308

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Investigation of lacrimal gland and extraocular muscle in thyroid eye disease patients with severe subjective dry eye disease: a multiparametric magnetic resonance imaging study.