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Objectives: Public's interest in noninvasive skin rejuvenation treatments continues to grow. The advantage of combination therapy lies in that it can target different aspects of skin rejuvenation. This study aimed to assess the efficacy and safety of microfocused ultrasound (MFU) combined with delicate pulsed light (DPL) for facial rejuvenation.

Methods: Twenty-one patients with facial relaxation were enrolled. All patients received whole-face MFU treatment, and one side of the face was randomly assigned to receive DPL. MFU treatment was performed at Months 0 and 3, while DPL treatment was performed at Months 1, 2, 4, and 5. The length and angle of the nasolabial fold and perioral wrinkles, melanin index (MI), erythema index (EI), transepidermal water loss (TEWL), and follow-up time were recorded at Months 0, 3, and 6. Side effects were recorded during treatment and each follow-up visit.

Results: Twenty patients successfully completed the study. At the sixth month, the average length of perioral wrinkles and nasolabial folds on the combined side decreased by 11.5% (p within < 0.001) and 6.5% (p within = 0.011), while 8.3% (p within = 0.012) and 3.8% (p within = 0.02) on the MFU side. Compared with MFU treatment alone, the combined treatment also showed significant improvements in nasolabial fold angle (from 28.8 ± 3.4° to 32.7 ± 5.0°) and perioral wrinkle angle (from 39.3 ± 5.0° to 43.7 ± 5.1°). In addition, the combined side had greater benefits than the MFU side in improving MI, EI, TEWL, and skin elasticity (p between < 0.05). Except for one patient who withdrew due to increased skin sensitivity after MFU treatment, other subjects did not experience permanent or serious side effects.

Conclusions: The combination of MFU and DPL for facial rejuvenation treatment is safe and effective. The combined treatment has better efficacy in skin firmness, and improving skin tone.

Titel:	Combined microfocused ultrasound and delicate pulsed light for facial rejuvenation: A prospective, randomized, and split-face study.
Autor/in / Beteiligte Person:	Wang, Y ; Liang, J ; Chen, Y ; Xia, J ; Liu, Y ; Liu, J ; Li, Y ; Yang, M ; Wang, Z ; Zeng, W
Link:	Full Text Finder (Volltext)
Zeitschrift:	Lasers in surgery and medicine, Jg. 56 (2024-04-01), Heft 4, S. 346-354
Veröffentlichung:	New York Ny : Wiley-Liss ; <i>Original Publication</i>: New York : Alan Liss, 2024
Medientyp:	academicJournal
ISSN:	1096-9101 (electronic)
DOI:	10.1002/lsm.23777
Schlagwort:	Humans Rejuvenation Prospective Studies Skin Ultrasonography Erythema Treatment Outcome Patient Satisfaction Cosmetic Techniques Skin Aging
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Randomized Controlled Trial; Journal Article Language: English [Lasers Surg Med] 2024 Apr; Vol. 56 (4), pp. 346-354. <i>Date of Electronic Publication: </i>2024 Mar 10. MeSH Terms: Cosmetic Techniques* ; Skin Aging* ; Humans ; Rejuvenation ; Prospective Studies ; Skin ; Ultrasonography ; Erythema ; Treatment Outcome ; Patient Satisfaction References: Kohl E, Steinbauer J, Landthaler M, Szeimies RM. Skin ageing. J Eur Acad Dermatol Venereol. 2011;25(8):873–884. ; Sales AFS, Pandolfo IL, de Almeida Cruz M, Parisi JR, Garcia LA, Martignago CCS, et al. Intense pulsed light on skin rejuvenation: a systematic review. Arch Dermatol Res. 2022;314(9):823–838. ; Ling J, Zhao H. A systematic review and meta‐analysis of the clinical efficacy and patients' satisfaction of micro‐focused ultrasound (MFU) treatment for facial rejuvenation and tightening. 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Combined microfocused ultrasound and delicate pulsed light for facial rejuvenation: A prospective, randomized, and split-face study.