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Background: Hyperthyroidism in humans is associated with a hypercoagulable state and an increased risk of thromboembolism.

Objective: To evaluate hemostatic variables in hyperthyroid and euthyroid cats with the hypothesis that hyperthyroid cats will have evidence of altered hemostasis consistent with a potential hypercoagulable state.

Animals: Client-owned hyperthyroid (n = 16) and euthyroid (n = 15) cats over 8 years of age.

Methods: Prospective observational study. Hyperthyroid and euthyroid cats were enrolled. Rotational thromboelastometry (ROTEM), whole-blood platelet impedance aggregometry (WBPIA) and a point-of-care viscoelastic coagulation monitor (VCM-Vet) were performed immediately after minimally traumatic venipuncture under sedation.

Results: Hyperthyroid cats had significantly higher values for variables as assessed by VCM-Vet: A10 (34 [17-47] vs 25 [17-38], P = .003); A20 (39.5 [23-55] vs 31 [21-45], P = .003); and MCF (41 [24-58] vs 35 [22-49], P = .03). Hyperthyroid cats had significantly different values versus the euthyroid cohort as assessed by different ROTEM channels: increased A10, INTEM (61.5 [39-75] vs 54 [23-66], P = .007) and FIBTEM (18 [10-35] vs 13 [2-27], P = .01); increased A20, INTEM (68 [45-78] vs 61 [30-70], P = .006) and FIBTEM (17 [10-34] vs 11 [2-25], P = .002); increased MCF, EXTEM (72 [65-81] vs 69 [34-78], P = .04), INTEM (70 [45-85] vs 62 [35-71], P = .01) and FIBTEM (18 [13-37] vs 14 [3-27], P = .02); increased alpha angle, EXTEM (80 [68-85] vs 76 [41-84], P = .01); shortened CT, EXTEM (52.5 [29-73] vs 60 [52-92], P = .003) and FIBTEM (52.5 [16-75] vs 65 [53-165], P = .001); and decreased ML, FIBTEM (20 [1-36] vs 33 [19-59], P <.001). No significant differences were found with WBPIA.

Conclusions and Clinical Importance: The hyperthyroid cats in this study had evidence of altered hemostasis as assessed by 2 viscoelastic methodologies, and characterized by increased clot amplitude, firmness, and faster coagulation times vs euthyroid controls.

Titel:	Assessment of hemostasis in hyperthyroid and euthyroid cats using two viscoelastic assays and platelet aggregometry.
Autor/in / Beteiligte Person:	Moreno, D ; Cosford, K ; Snead, E ; Carr, A
Link:	Full Text Finder (Volltext)
Zeitschrift:	Journal of veterinary internal medicine, Jg. 38 (2024-05-01), Heft 3, S. 1377-1383
Veröffentlichung:	<2010-> : Malden, MA : Wiley Periodicals ; <i>Original Publication</i>: Philadelphia : J.B. Lippincott Co., [c1987-, 2024
Medientyp:	academicJournal
ISSN:	1939-1676 (electronic)
DOI:	10.1111/jvim.17038
Schlagwort:	Animals Cats Female Male Prospective Studies Platelet Aggregation Cat Diseases blood Hyperthyroidism veterinary Hyperthyroidism blood Thrombelastography veterinary Hemostasis
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [J Vet Intern Med] 2024 May-Jun; Vol. 38 (3), pp. 1377-1383. <i>Date of Electronic Publication: </i>2024 Mar 11. MeSH Terms: Cat Diseases* / blood ; Hyperthyroidism* / veterinary ; Hyperthyroidism* / blood ; Thrombelastography* / veterinary ; Hemostasis* ; Animals ; Cats ; Female ; Male ; Prospective Studies ; Platelet Aggregation References: Vet Clin Pathol. 2020 Dec;49(4):660-664. (PMID: 33207006) ; J Vet Intern Med. 2024 May-Jun;38(3):1377-1383. (PMID: 38465916) ; Vet Clin North Am Small Anim Pract. 2020 Nov;50(6):1397-1409. (PMID: 32981595) ; Vet Radiol Ultrasound. 2015 Jan-Feb;56(1):84-95. (PMID: 24798491) ; Vet Clin Pathol. 2010 Dec;39(4):405-16. (PMID: 20969608) ; J Feline Med Surg. 2017 Mar;19(3):288-303. (PMID: 28245741) ; Top Companion Anim Med. 2016 Mar;31(1):11-7. (PMID: 27451044) ; J Thromb Haemost. 2010 Oct;8(10):2176-81. (PMID: 20738759) ; Vet Clin Pathol. 2011 Jun;40(2):140-53. (PMID: 21446994) ; J Vet Intern Med. 2021 Nov;35(6):2636-2645. (PMID: 34590754) ; J Clin Endocrinol Metab. 2007 Aug;92(8):3006-12. (PMID: 17488803) ; Thromb Haemost. 2012 Dec;108(6):1077-88. (PMID: 23014708) ; Scand J Clin Lab Invest. 2020 Nov;80(7):600-605. (PMID: 32924629) ; J Vet Intern Med. 2014 Jan-Feb;28(1):102-8. (PMID: 24237457) ; Eur J Endocrinol. 2015 May;172(5):537-42. (PMID: 25637077) ; J Trauma. 2009 Aug;67(2):266-75; discussion 275-6. (PMID: 19667878) ; J Feline Med Surg. 2019 Dec;21(12):1134-1140. (PMID: 30571457) ; Stroke. 2010 May;41(5):961-6. (PMID: 20360542) ; J Vet Emerg Crit Care (San Antonio). 2009 Feb;19(1):3-10. (PMID: 19691581) ; J Feline Med Surg. 2020 Dec;22(12):1214-1218. (PMID: 32436801) ; Am J Vet Res. 1994 May;55(5):619-27. (PMID: 8067608) ; J Thromb Haemost. 2014 Jun;12(6):839-46. (PMID: 24679097) ; Adv Exp Med Biol. 2017;956:511-540. (PMID: 28035582) ; J Vet Intern Med. 2003 Jan-Feb;17(1):73-83. (PMID: 12564730) Grant Information: PRJ0419 Companion Animal Health Fund Contributed Indexing: Keywords: coagulation; fibrinogen; hypercoagulable; hyperthyroidism; impedance; monitor; rotational; thromboelastometry Entry Date(s): Date Created: 20240311 Date Completed: 20240517 Latest Revision: 20240519 Update Code: 20240519 PubMed Central ID: PMC11099719

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Assessment of hemostasis in hyperthyroid and euthyroid cats using two viscoelastic assays and platelet aggregometry.