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Objectives: The present study examines the temporal association between the changes in SARS-CoV-2 viral load during infection and whether the CoLab-score can facilitate de-isolation.

Methods: Nasal swabs and blood samples were collected from ICU-admitted SARS-CoV-2 positive patients at Maastricht UMC+ from March 25, 2020 to October 1, 2021. The CoLab-score was calculated based on 10 blood parameters and age and can range from -43 to 6. Three mixed effects analyses compared patient categories based on initial PCR Ct values (low; Ct≤20, mid; 20>Ct≤30, high; Ct>30), serial PCR Ct values to CoLab-scores over time, and the association between within-patient delta Ct values and CoLab-scores.

Results: In 324 patients, the median Ct was 33, and the median CoLab-score was -1.78. Mid (n=110) and low (n=41) Ct-categories had higher CoLab-scores over time (+0.60 points, 95 % CI; 0.04-1.17, and +0.28 points, 95 % CI -0.49 to 1.04) compared to the high Ct (n=87) category. Over time, higher serial Ct values were associated with lower serial CoLab-scores, decreasing by -0.07 points (95 % CI; -0.11 to -0.02) per day. Increasing delta Ct values were associated with a decreasing delta CoLab-score of -0.12 (95 % CI; -0.23; -0.01).

Conclusions: The study found an association between lower viral load on admission and reduced CoLab-score. Additionally, a decrease in viral load over time was associated with a decrease in CoLab-score. Therefore, the CoLab-score may make patient de-isolation an option based on the CoLab-score.

Titel:	The CoLab score is associated with SARS-CoV-2 viral load during admission in individuals admitted to the intensive care unit: the CoLaIC cohort study.
Autor/in / Beteiligte Person:	Schoenmakers, T ; Leers, MPG ; Deneer, R ; van Rosmalen F ; Gorissen, SHM ; Verboeket-van de Venne, WPHG ; Vojinovic, U ; van Mook WNKA ; Wolffs, PFG ; van Bussel BCT ; van Loo IHM
Zeitschrift:	Clinical chemistry and laboratory medicine, Jg. 62 (2024-03-20), Heft 6, S. 1228-1236
Veröffentlichung:	Berlin ; New York : Walter De Gruyter, c1998-, 2024
Medientyp:	academicJournal
ISSN:	1437-4331 (electronic)
DOI:	10.1515/cclm-2024-0030
Schlagwort:	Humans Middle Aged Male Female Cohort Studies Aged Adult Hospitalization COVID-19 virology COVID-19 diagnosis Viral Load SARS-CoV-2 isolation & purification Intensive Care Units
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Clin Chem Lab Med] 2024 Mar 20; Vol. 62 (6), pp. 1228-1236. <i>Date of Electronic Publication: </i>2024 Mar 20 (<i>Print Publication: </i>2024). MeSH Terms: COVID-19* / virology ; COVID-19* / diagnosis ; Viral Load* ; SARS-CoV-2* / isolation & purification ; Intensive Care Units* ; Humans ; Middle Aged ; Male ; Female ; Cohort Studies ; Aged ; Adult ; Hospitalization References: Brinkman, S, de Keizer, NF, de Lange, DW, Dongelmans, DA, Termorshuizen, F, van Bussel, BCT. Strain on scarce intensive care beds drives reduced patient volumes, patient selection, and worse outcome: a national cohort study. Crit Care Med 2023. https://doi.org/10.1097/ccm.0000000000006156 . (PMID: 10.1097/ccm.0000000000006156) ; Jin, Y, Sun, T, Zheng, P, An, J. Mass quarantine and mental health during COVID-19: a meta-analysis. J Affect Disord 2021;295:1335–46. https://doi.org/10.1016/j.jad.2021.08.067 . 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The CoLab score is associated with SARS-CoV-2 viral load during admission in individuals admitted to the intensive care unit: the CoLaIC cohort study.