Joint analysis of vaccination effectiveness and antiviral drug effectiveness for COVID-19: a causal inference approach.
In: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, Jg. 143 (2024-06-01), S. 107012
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Zugriff:
Objectives: This study aims to estimate the causal effects of oral antivirals and vaccinations in the prevention of all-cause mortality and progression to severe COVID-19 in an integrative setting with both antivirals and vaccinations considered as interventions.
Methods: We identified hospitalized adult patients (i.e. aged 18 or above) in Hong Kong with confirmed SARS-CoV-2 infection between March 16, 2022, and December 31, 2022. An inverse probability-weighted (IPW) Andersen-Gill model with time-dependent predictors was used to address immortal time bias and produce causal estimates for the protection effects of oral antivirals and vaccinations against severe COVID-19.
Results: Given prescription is made within 5 days of confirmed infection, nirmatrelvir-ritonavir is more effective in providing protection against all-cause mortality and development into severe COVID-19 than molnupiravir. There was no significant difference between CoronaVac and Comirnaty in the effectiveness of reducing all-cause mortality and progression to severe COVID-19.
Conclusions: The use of oral antivirals and vaccinations causes lower risks of all-cause mortality and progression to severe COVID-19 for hospitalized SARS-CoV-2 patients.
Competing Interests: Declaration of competing interest BJC consults for AstraZeneca, Fosun Pharma, GlaxoSmithKline, Haleon, Moderna, Novavax, Pfizer, Roche and Sanofi Pasteur. The other authors report no other potential conflicts of interest.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
| Titel: |
Joint analysis of vaccination effectiveness and antiviral drug effectiveness for COVID-19: a causal inference approach.
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| Autor/in / Beteiligte Person: | Cheung, YYH ; Lau, EHY ; Yin, G ; Lin, Y ; Jiang, J ; Cowling, BJ ; Lam, KF |
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| Zeitschrift: | International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, Jg. 143 (2024-06-01), S. 107012 |
| Veröffentlichung: | Hamilton, ON : Elsevier ; <i>Original Publication</i>: Hamilton, ON : Decker, c1996-, 2024 |
| Medientyp: | academicJournal |
| ISSN: | 1878-3511 (electronic) |
| DOI: | 10.1016/j.ijid.2024.107012 |
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