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Streptococcus suis is a leading cause of infection in pigs, causing extensive economic losses. In addition, it can also infect wild fauna, and can be responsible for severe infections in humans. Increasing antimicrobial resistance (AMR) has been described in S. suis worldwide and most of the AMR genes are carried by mobile genetic elements (MGEs). This contributes to their dissemination by horizontal gene transfer. A collection of 102 strains isolated from humans, pigs and wild boars in France was subjected to whole genome sequencing in order to: (i) study their genetic diversity, (ii) evaluate their content in virulence-associated genes, (iii) decipher the mechanisms responsible for their AMR and their association with MGEs, and (iv) study their ability to acquire extracellular DNA by natural transformation. Analysis by hierarchical clustering on principal components identified a few virulence-associated factors that distinguish invasive CC1 strains from the other strains. A plethora of AMR genes ( n =217) was found in the genomes. Apart from the frequently reported erm (B) and tet (O) genes, more recently described AMR genes were identified [ vga (F)/ sprA , vat (D)]. Modifications in PBPs/MraY and GyrA/ParC were detected in the penicillin- and fluoroquinolone-resistant isolates respectively. New AMR gene-MGE associations were detected. The majority of the strains have the full set of genes required for competence, i.e for the acquisition of extracellular DNA (that could carry AMR genes) by natural transformation. Hence the risk of dissemination of these AMR genes should not be neglected.

Titel:	Virulence genes, resistome and mobilome of Streptococcus suis strains isolated in France.
Autor/in / Beteiligte Person:	Dechêne-Tempier, M ; de Boisséson C ; Lucas, P ; Bougeard, S ; Libante, V ; Marois-Créhan, C ; Payot, S
Link:	Full Text Finder (Volltext)
Zeitschrift:	Microbial genomics, Jg. 10 (2024-03-01), Heft 3
Veröffentlichung:	Oct. 2015- : [London] : Microbiology Society ; <i>Original Publication</i>: [London] : Society for General Microbiology, [2015]-, 2024
Medientyp:	academicJournal
ISSN:	2057-5858 (electronic)
DOI:	10.1099/mgen.0.001224
Schlagwort:	Humans Animals Swine Virulence France Virulence Factors DNA Streptococcus suis
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Microb Genom] 2024 Mar; Vol. 10 (3). MeSH Terms: Streptococcus suis* ; Humans ; Animals ; Swine ; Virulence ; France ; Virulence Factors ; DNA References: NAR Genom Bioinform. 2022 Oct 21;4(4):lqac079. (PMID: 36285285) ; Pathogens. 2020 Jan 27;9(2):. (PMID: 32012668) ; Trends Microbiol. 2017 Jul;25(7):585-599. (PMID: 28274524) ; FEMS Microbiol Rev. 2014 Jul;38(4):720-60. (PMID: 24372381) ; Bioinformatics. 2013 Apr 15;29(8):1072-5. (PMID: 23422339) ; Bioinformatics. 2014 Jul 15;30(14):2068-9. (PMID: 24642063) ; Vet Microbiol. 2000 Jun 1;74(3):237-48. (PMID: 10808092) ; Vet Res. 2020 Jul 8;51(1):85. (PMID: 32641158) ; Nat Commun. 2015 Mar 31;6:6740. (PMID: 25824154) ; J Clin Microbiol. 2019 Jun 25;57(7):. (PMID: 30944194) ; Sci Rep. 2023 May 22;13(1):8263. (PMID: 37217544) ; Int J Antimicrob Agents. 2019 Mar;53(3):318-324. (PMID: 30582984) ; J Antimicrob Chemother. 2019 Feb 1;74(2):298-310. (PMID: 30357339) ; Pathogens. 2016 Jun 24;5(3):. (PMID: 27348006) ; Biosci Trends. 2014 Apr;8(2):84-92. (PMID: 24815385) ; Front Microbiol. 2017 Mar 20;8:443. (PMID: 28373865) ; Int J Antimicrob Agents. 2019 Jul;54(1):43-48. (PMID: 30981924) ; Genome Biol Evol. 2017 Apr 1;9(4):1000-1012. (PMID: 28379509) ; Microorganisms. 2021 Aug 18;9(8):. (PMID: 34442843) ; Nat Rev Microbiol. 2010 Aug;8(8):552-63. (PMID: 20601965) ; Emerg Microbes Infect. 2014 Jun;3(6):e45. (PMID: 26038745) ; PLoS One. 2014 Jun 26;9(6):e99394. (PMID: 24968201) ; Bioinformatics. 2015 Nov 15;31(22):3691-3. (PMID: 26198102) ; Nucleic Acids Res. 2020 Jan 8;48(D1):D517-D525. (PMID: 31665441) ; Front Microbiol. 2016 Dec 20;7:1922. (PMID: 28066332) ; J Clin Microbiol. 2023 Sep 21;61(9):e0016423. (PMID: 37655935) ; Front Microbiol. 2022 Nov 10;13:1043529. (PMID: 36439859) ; Transbound Emerg Dis. 2019 Mar;66(2):995-1003. (PMID: 30676694) ; ISME J. 2017 Dec;11(12):2864-2868. (PMID: 28742071) ; Front Microbiol. 2015 Nov 04;6:1191. (PMID: 26583006) ; Microbiol Resour Announc. 2019 Jan 31;8(5):. (PMID: 30714039) ; Vet Res. 2017 Feb 20;48(1):10. (PMID: 28219415) ; Pathogens. 2019 Dec 25;9(1):. (PMID: 31881744) ; Trends Microbiol. 2018 May;26(5):389-391. (PMID: 29588109) ; Bioinformatics. 2018 Sep 1;34(17):i884-i890. (PMID: 30423086) ; J Antimicrob Chemother. 2012 Nov;67(11):2640-4. (PMID: 22782487) ; Microb Genom. 2023 Feb;9(2):. (PMID: 36790403) ; Appl Environ Microbiol. 2015 Feb;81(3):976-85. (PMID: 25416757) ; Front Cell Infect Microbiol. 2016 Oct 07;6:118. (PMID: 27774436) ; J Clin Microbiol. 2002 Oct;40(10):3671-80. (PMID: 12354864) ; Bioinformatics. 2016 Sep 15;32(18):2847-9. (PMID: 27207943) ; FEBS Lett. 2016 Nov;590(21):3772-3799. (PMID: 27539145) ; BMC Microbiol. 2016 Jul 22;16(1):162. (PMID: 27449127) ; Pathogens. 2021 Sep 13;10(9):. (PMID: 34578210) ; Vet Res. 2000 Sep-Oct;31(5):473-9. (PMID: 11050742) ; Sci Rep. 2021 Mar 22;11(1):6513. (PMID: 33753801) ; FEMS Microbiol Lett. 2004 Dec 15;241(2):129-34. (PMID: 15598523) ; Mol Biol Evol. 2020 May 1;37(5):1530-1534. (PMID: 32011700) ; Bioinformatics. 2015 Aug 1;31(15):2443-51. (PMID: 25810435) ; Trends Microbiol. 2006 Aug;14(8):339-45. (PMID: 16820295) ; Antimicrob Agents Chemother. 2007 Feb;51(2):777-82. (PMID: 17116660) ; BMC Biol. 2021 Sep 7;19(1):191. (PMID: 34493269) ; Genome Res. 2015 Jul;25(7):1043-55. (PMID: 25977477) ; Future Microbiol. 2012 Feb;7(2):259-79. (PMID: 22324994) ; Vet Anim Sci. 2019 Apr 06;7:100058. (PMID: 32734079) ; Microorganisms. 2021 Nov 20;9(11):. (PMID: 34835517) ; Genes (Basel). 2017 Nov 22;8(11):. (PMID: 29165361) ; Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19126-31. (PMID: 19855009) ; Antibiotics (Basel). 2023 Jan 12;12(1):. (PMID: 36671359) ; Bioinformatics. 2017 Sep 15;33(18):2938-2940. (PMID: 28645171) ; J Clin Microbiol. 2013 Aug;51(8):2582-91. (PMID: 23720795) ; Nat Methods. 2017 Jun;14(6):587-589. (PMID: 28481363) ; Microbiol Spectr. 2023 Jun 15;11(3):e0030923. (PMID: 37154736) ; Cold Spring Harb Perspect Med. 2016 Nov 1;6(11):. (PMID: 27549310) ; Front Vet Sci. 2021 Aug 19;8:709327. (PMID: 34490399) ; J Clin Microbiol. 2015 Jul;53(7):2332-6. (PMID: 25903569) ; Appl Environ Microbiol. 2013 Apr;79(8):2796-806. (PMID: 23416996) ; Wellcome Open Res. 2018 Sep 24;3:124. (PMID: 30345391) ; Nat Commun. 2022 Nov 15;13(1):6968. (PMID: 36379955) ; J Bacteriol. 2004 Jul;186(14):4740-7. (PMID: 15231806) ; Front Microbiol. 2016 Jan 06;6:1483. (PMID: 26779141) ; PLoS One. 2011;6(9):e24988. (PMID: 21966396) Contributed Indexing: Keywords: Streptococcus suis; competence; integrative conjugative elements; mobilizable elements; resistance genes; virulence Substance Nomenclature: 0 (Virulence Factors) ; 9007-49-2 (DNA) Entry Date(s): Date Created: 20240327 Date Completed: 20240328 Latest Revision: 20240407 Update Code: 20240407 PubMed Central ID: PMC10995628

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Virulence genes, resistome and mobilome of Streptococcus suis strains isolated in France.