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Antiviral susceptibility of influenza viruses was assessed using a high-content imaging-based neutralization test. Cap-dependent endonuclease inhibitors, baloxavir and AV5116, were superior to AV5115 against type A viruses, and AV5116 was most effective against PA mutants tested. However, these three inhibitors displayed comparable activity (EC 50 8-22 nM) against type C viruses from six lineages. Banana lectin and a monoclonal antibody, YA3, targeting the hemagglutinin-esterase protein effectively neutralized some, but not all, type C viruses.

Competing Interests: Andrei A. Ivashchenko and Alexandre V. Ivachtchenko are the cofounders of ChemDiv, managing members of AVISA LCC. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Titel:	Influenza C virus susceptibility to antivirals with different mechanisms of action.
Autor/in / Beteiligte Person:	Chesnokov, A ; Ivashchenko, AA ; Matsuzaki, Y ; Takashita, E ; Mishin, VP ; Ivachtchenko, AV ; Gubareva, LV
Zeitschrift:	Antimicrobial agents and chemotherapy, Jg. 68 (2024-05-02), Heft 5, S. e0172723
Veröffentlichung:	Washington, American Society for Microbiology, 2024
Medientyp:	academicJournal
ISSN:	1098-6596 (electronic)
DOI:	10.1128/aac.01727-23
Schlagwort:	Humans Gammainfluenzavirus drug effects Gammainfluenzavirus genetics Morpholines pharmacology Pyridones pharmacology Animals Antibodies, Monoclonal pharmacology Madin Darby Canine Kidney Cells Dogs Cyclopropanes pharmacology Influenza A virus drug effects Neutralization Tests Pyridines pharmacology Antiviral Agents pharmacology Triazines pharmacology Dibenzothiepins pharmacology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Antimicrob Agents Chemother] 2024 May 02; Vol. 68 (5), pp. e0172723. <i>Date of Electronic Publication: </i>2024 Apr 08. MeSH Terms: Antiviral Agents* / pharmacology ; Triazines* / pharmacology ; Dibenzothiepins* / pharmacology ; Humans ; Gammainfluenzavirus / drug effects ; Gammainfluenzavirus / genetics ; Morpholines / pharmacology ; Pyridones / pharmacology ; Animals ; Antibodies, Monoclonal / pharmacology ; Madin Darby Canine Kidney Cells ; Dogs ; Cyclopropanes / pharmacology ; Influenza A virus / drug effects ; Neutralization Tests ; Pyridines / pharmacology References: Pathogens. 2021 Dec 05;10(12):. (PMID: 34959538) ; Antimicrob Agents Chemother. 1988 Jun;32(6):906-11. (PMID: 3415210) ; Antiviral Res. 2023 Feb;210:105499. (PMID: 36567025) ; Sci Rep. 2019 Feb 25;9(1):2676. (PMID: 30804469) ; Viruses. 2018 Aug 09;10(8):. (PMID: 30096880) ; Proc Natl Acad Sci U S A. 1990 May;87(9):3430-4. (PMID: 2333292) ; Proc Natl Acad Sci U S A. 2020 Jan 28;117(4):2122-2132. (PMID: 31932446) ; Cell. 2015 Oct 22;163(3):746-58. (PMID: 26496612) ; Antimicrob Agents Chemother. 2002 Apr;46(4):977-81. (PMID: 11897578) ; Euro Surveill. 2019 Jan;24(3):. (PMID: 30670144) ; Antiviral Res. 2018 May;153:85-94. (PMID: 29524445) ; Emerg Infect Dis. 2019 Oct;25(10):1969-1972. (PMID: 31287050) ; Viruses. 2023 Jan 15;15(1):. (PMID: 36680284) ; Antiviral Res. 2023 Sep;217:105679. (PMID: 37494978) ; J Virol. 2020 Oct 14;94(21):. (PMID: 32817211) ; PLoS Pathog. 2012;8(8):e1002830. (PMID: 22876176) ; Antiviral Res. 2022 Dec;208:105457. (PMID: 36332755) ; J Virol. 1977 Dec;24(3):875-82. (PMID: 73602) ; J Antimicrob Chemother. 2021 Mar 12;76(4):1010-1018. (PMID: 33367751) Contributed Indexing: Keywords: baloxavir; cap-dependent endonuclease inhibitors; drug susceptibility; lectin; polymerase Substance Nomenclature: 0 (Antiviral Agents) ; 4G86Y4JT3F (baloxavir) ; 0 (Triazines) ; 0 (Dibenzothiepins) ; 0 (Morpholines) ; 0 (Pyridones) ; 0 (Antibodies, Monoclonal) ; 0 (Cyclopropanes) ; 0 (Pyridines) Entry Date(s): Date Created: 20240408 Date Completed: 20240502 Latest Revision: 20240504 Update Code: 20240504 PubMed Central ID: PMC11064526

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Influenza C virus susceptibility to antivirals with different mechanisms of action.