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- Nachgewiesen in: MEDLINE
- Sprachen: English
- Publication Type: Research Support, Non-U.S. Gov't; Journal Article; Research Support, N.I.H., Extramural; Letter
- Language: English
- [Nat Immunol] 2024 May; Vol. 25 (5), pp. 737-738.
- MeSH Terms: Positive Regulatory Domain I-Binding Factor 1* / metabolism ; Positive Regulatory Domain I-Binding Factor 1* / genetics ; Colitis* / immunology ; Proto-Oncogene Proteins c-maf* / metabolism ; Animals ; Mice ; Mice, Knockout ; Humans ; Signal Transduction / immunology ; Mice, Inbred C57BL ; Disease Models, Animal
- References: Uhlig, H. H. & Powrie, F. Translating immunology into therapeutic concepts for inflammatory bowel disease. Annu. Rev. Immunol. 36, 755–781 (2018). This review discusses the genetics and environmental factors implicated in IBD, the importance of mouse models and progress in development of targeted therapies. (PMID: 10.1146/annurev-immunol-042617-05305529677472) ; Imbratta, C., Hussein, H., Andris, F. & Verdeil, G. c-MAF, a Swiss army knife for tolerance in lymphocytes. Front. Immunol. 11, 206 (2020). This review discusses the various roles of c-MAF in T cell differentiation, function and homeostasis, including positive regulation of IL-10 in multiple T cell subsets. (PMID: 10.3389/fimmu.2020.00206321173177033575) ; Neumann, C., Scheffold, A. & Rutz, S. Functions and regulation of T cell-derived interleukin-10. Semin. Immunol. 44, 101344 (2019). This review on T cell-derived IL-10 summarizes extensive literature on positive regulation of IL-10 by c-MAF and BLIMP-1. (PMID: 10.1016/j.smim.2019.10134431727465) ; Cox, L. S. et al. Blimp-1 and c-Maf regulate Il10 and negatively regulate common and unique proinflammatory gene networks in IL-12 plus IL-27-driven T helper-1 cells. Wellcome Open Res. 8, 403 (2023). This paper describes the identification of common and distinct inflammatory networks regulated by c-MAF and BLIMP-1 in mouse T H 1 cells driven by IL-12 and IL-27 in vitro. (PMID: 10.12688/wellcomeopenres.19680.23807419710709690) ; Zhang, H. et al. An IL-27-driven transcriptional network identifies regulators of IL-10 expression across T helper cell subsets. Cell Rep. 33, 108433 (2020). The authors report transcription factors that mediate IL-27-dependent expression of IL-10 in CD4 + T cells, and spontaneous colitis arising in mice with deletion of Maf and Prdm1 in T cells. (PMID: 10.1016/j.celrep.2020.108433332381237771052)
- Substance Nomenclature: EC 2.1.1.- (Positive Regulatory Domain I-Binding Factor 1) ; 0 (Prdm1 protein, mouse) ; 0 (Proto-Oncogene Proteins c-maf)
- Entry Date(s): Date Created: 20240419 Date Completed: 20240502 Latest Revision: 20240522
- Update Code: 20240522
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