Einzeltreffer — DigiBib

In 2017, a novel influenza A virus (IAV) was isolated from an Egyptian fruit bat. In contrast to other bat influenza viruses, the virus was related to avian A(H9N2) viruses and was probably the result of a bird-to-bat transmission event. To determine the cross-species spill-over potential, we biologically characterize features of A/bat/Egypt/381OP/2017(H9N2). The virus has a pH inactivation profile and neuraminidase activity similar to those of human-adapted IAVs. Despite the virus having an avian virus-like preference for α2,3 sialic acid receptors, it is unable to replicate in male mallard ducks; however, it readily infects ex-vivo human respiratory cell cultures and replicates in the lungs of female mice. A/bat/Egypt/381OP/2017 replicates in the upper respiratory tract of experimentally-infected male ferrets featuring direct-contact and airborne transmission. These data suggest that the bat A(H9N2) virus has features associated with increased risk to humans without a shift to a preference for α2,6 sialic acid receptors.

Titel:	Cross-species spill-over potential of the H9N2 bat influenza A virus.
Autor/in / Beteiligte Person:	El-Shesheny, R ; Franks, J ; Kandeil, A ; Badra, R ; Turner, J ; Seiler, P ; Marathe, BM ; Jeevan, T ; Kercher, L ; Hu, M ; Sim, YE ; Hui, KPY ; Chan, MCW ; Thompson, AJ ; McKenzie, P ; Govorkova, EA ; Russell, CJ ; Vogel, P ; Paulson, JC ; Peiris, JSM ; Webster, RG ; Ali, MA ; Kayali, G ; Webby, RJ
Link:	View record at Springer (Volltext)
Zeitschrift:	Nature communications, Jg. 15 (2024-04-25), Heft 1, S. 3449
Veröffentlichung:	[London] : Nature Pub. Group, 2024
Medientyp:	academicJournal
ISSN:	2041-1723 (electronic)
DOI:	10.1038/s41467-024-47635-4
Schlagwort:	Animals Humans Female Male Mice Virus Replication Influenza, Human virology Influenza, Human transmission Lung virology Influenza in Birds virology Influenza in Birds transmission Neuraminidase metabolism Chiroptera virology Ferrets virology Influenza A Virus, H9N2 Subtype physiology Influenza A Virus, H9N2 Subtype pathogenicity Influenza A Virus, H9N2 Subtype isolation & purification Orthomyxoviridae Infections virology Orthomyxoviridae Infections transmission Ducks virology Receptors, Cell Surface
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural Language: English [Nat Commun] 2024 Apr 25; Vol. 15 (1), pp. 3449. <i>Date of Electronic Publication: </i>2024 Apr 25. MeSH Terms: Chiroptera* / virology ; Ferrets* / virology ; Influenza A Virus, H9N2 Subtype* / physiology ; Influenza A Virus, H9N2 Subtype* / pathogenicity ; Influenza A Virus, H9N2 Subtype* / isolation & purification ; Orthomyxoviridae Infections* / virology ; Orthomyxoviridae Infections* / transmission ; Ducks* / virology ; Receptors, Cell Surface* ; Animals ; Humans ; Female ; Male ; Mice ; Virus Replication ; Influenza, Human / virology ; Influenza, Human / transmission ; Lung / virology ; Influenza in Birds / virology ; Influenza in Birds / transmission ; Neuraminidase / metabolism References: Arch Virol. 2012 Feb;157(2):247-57. (PMID: 22068881) ; Glycobiology. 2016 Nov 22;27(4):280-284. (PMID: 27993942) ; Sci Rep. 2017 Apr 6;7(1):660. (PMID: 28386114) ; Anal Biochem. 1979 Apr 15;94(2):287-96. (PMID: 464297) ; Proc Natl Acad Sci U S A. 2016 Feb 9;113(6):1636-41. (PMID: 26811446) ; Clin Microbiol Rev. 2006 Jul;19(3):531-45. (PMID: 16847084) ; J Virol. 2016 Oct 14;90(21):9806-9825. (PMID: 27558420) ; Lancet Respir Med. 2018 Nov;6(11):846-854. (PMID: 30001996) ; Cell Host Microbe. 2017 Jan 11;21(1):23-34. (PMID: 28017661) ; Nature. 2021 Dec;600(7889):408-418. (PMID: 34880490) ; Front Microbiol. 2019 Jan 29;10:39. (PMID: 30761095) ; Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4269-74. (PMID: 22371588) ; Lancet Respir Med. 2020 Jul;8(7):687-695. (PMID: 32386571) ; Nat Rev Microbiol. 2022 May;20(5):299-314. (PMID: 34799704) ; J Virol. 2013 May;87(9):4826-34. (PMID: 23449784) ; PLoS Pathog. 2015 Jun 04;11(6):e1004819. (PMID: 26042416) ; J Immunol. 2009 Jan 15;182(2):1088-98. (PMID: 19124752) ; J Virol. 2019 Mar 5;93(6):. (PMID: 30567980) ; Vet Sci. 2018 Sep 21;5(4):. (PMID: 30248906) ; Sci Rep. 2023 Sep 22;13(1):15829. (PMID: 37739999) ; Viruses. 2021 Apr 14;13(4):. (PMID: 33919890) ; Front Cell Infect Microbiol. 2020 Jun 03;10:264. (PMID: 32582567) ; Zoonoses Public Health. 2015 May;62(3):187-9. (PMID: 24837569) ; Nat Microbiol. 2019 Dec;4(12):2298-2309. (PMID: 31527796) ; Trends Microbiol. 2018 Oct;26(10):841-853. (PMID: 29681430) ; Viruses. 2021 Mar 25;13(4):. (PMID: 33805956) ; J Virol. 2019 Jan 4;93(2):. (PMID: 30381492) ; Emerg Infect Dis. 2018 Mar;24(3):471-477. (PMID: 29460739) ; PLoS One. 2008 Aug 13;3(8):e2923. (PMID: 18698430) ; PLoS Pathog. 2021 Sep 3;17(9):e1009910. (PMID: 34478484) ; PLoS Pathog. 2013;9(10):e1003657. (PMID: 24130481) ; PeerJ. 2021 Dec 20;9:e12512. (PMID: 35036116) ; J Virol. 2010 Feb;84(3):1527-35. (PMID: 19923184) ; Emerg Microbes Infect. 2013 Nov;2(11):e75. (PMID: 26038443) ; Transbound Emerg Dis. 2022 Mar;69(2):669-684. (PMID: 33566453) ; Emerg Infect Dis. 2019 Feb;25(2):333-337. (PMID: 30666923) ; J Infect Dis. 2011 Dec 15;204(12):1866-78. (PMID: 22013225) ; Eur Respir J. 2017 Mar 8;49(3):. (PMID: 28275173) ; Cold Spring Harb Perspect Med. 2021 Feb 1;11(2):. (PMID: 31871229) ; PLoS Pathog. 2020 Apr 16;16(4):e1008384. (PMID: 32298389) Grant Information: 75N93021C00016 United States AI NIAID NIH HHS; HHSN272201400006C United States AI NIAID NIH HHS; R01 AI114730 United States AI NIAID NIH HHS; R01 AI150745 United States AI NIAID NIH HHS Substance Nomenclature: EC 3.2.1.18 (Neuraminidase) ; 0 (sialic acid receptor) ; 0 (Receptors, Cell Surface) Entry Date(s): Date Created: 20240425 Date Completed: 20240425 Latest Revision: 20240508 Update Code: 20240508 PubMed Central ID: PMC11045754

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Cross-species spill-over potential of the H9N2 bat influenza A virus.