Green synthesis for diverse bioactive benzo-fused spiroindolines through DBU-catalysed post-Ugi double cyclization.
In: Chemical communications (Cambridge, England), Jg. 60 (2024-05-16), Heft 41, S. 5455-5458
academicJournal
Zugriff:
A metal-free protocol utilizing DBU catalysis for post-Ugi amide-ester exchange and Conia-ene double cyclization has been successfully developed, allowing the synthesis of diverse highly functionalized benzo-fused spiroindolines with anti-cancer activities under mild conditions. Remarkably, this methodology demonstrates promising prospects for green chemistry, as it allows for the preparation of the spiroindolines in water. Control experiments indicate that a crucial role of the cyclic imide, specifically ring rigidification, facilitates the subsequent Conia-ene cyclization.
Titel: |
Green synthesis for diverse bioactive benzo-fused spiroindolines through DBU-catalysed post-Ugi double cyclization.
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Autor/in / Beteiligte Person: | Zhao, S ; Chen, M ; Zhou, W ; Ni, D ; Li, Z ; Nie, S ; He, Y |
Zeitschrift: | Chemical communications (Cambridge, England), Jg. 60 (2024-05-16), Heft 41, S. 5455-5458 |
Veröffentlichung: | Cambridge : Royal Society of Chemistry, 2024 |
Medientyp: | academicJournal |
ISSN: | 1364-548X (electronic) |
DOI: | 10.1039/d4cc00846d |
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