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Background: To explore the correlation between serum uric acid (SUA) and prognosis in patients with chronic heart failure (CHF) after revascularization.

Methods: A total of 126 patients with CHF undergoing revascularization [coronary artery intervention (PCI) or coronary artery bypass grafting (CABG)] in the hospital were enrolled as CHF group between December 2021 and October 2022, while 126 healthy controls during the same period were enrolled as healthy control group. The levels of SUA, inflammatory factors and cardiac function in the two groups were detected. The correlation between SUA level and inflammatory factors, cardiac function levels was analyzed. All patients in CHF group were followed up for 6 months to observe prognosis. The differences in the above indexes among patients with different prognosis were compared. The risk factors of prognosis were analyzed by multivariate Logistic regression analysis, and their predictive value for prognosis was evaluated by ROC curves analysis.

Competing Interests: All the authors declare that they have no conflict of interest in this work.Conflict of Interest: The authors stated that they have no conflicts of interest regarding the publication of this article.

(2024 Bo Miao, Jing Wu, Wang Jiao, Li Yanxin, Yingxiao Da, Wang Dong, Bei Gao, published by CEON/CEES.)

Titel:	Correlation between SUA and prognosis in CHF patients after revascularization.
Autor/in / Beteiligte Person:	Miao, B ; Wu, J ; Jiao, W ; Yanxin, L ; Da, Y ; Dong, W ; Gao, B
Link:	Volltext (PDF)
Zeitschrift:	Journal of medical biochemistry, Jg. 43 (2024-04-23), Heft 2, S. 193-199
Veröffentlichung:	2020- : Belgrade : Society of Medical Biochemists of Serbia ; <i>Original Publication</i>: Belgrade : Society of Medical Biochemists of Serbia, 2024
Medientyp:	academicJournal
ISSN:	1452-8258 (print)
DOI:	10.5937/jomb0-45322
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [J Med Biochem] 2024 Apr 23; Vol. 43 (2), pp. 193-199. References: Zhonghua Yi Xue Za Zhi. 2018 May 8;98(17):1337-1341. (PMID: 29764035) ; Histol Histopathol. 2022 Aug;37(8):803-812. (PMID: 35333374) ; JAMA Cardiol. 2022 Jan 1;7(1):17-25. (PMID: 34730769) ; Oxid Med Cell Longev. 2019 Oct 9;2019:9246138. (PMID: 31687090) ; Eur Heart J. 2022 Sep 21;43(36):3435-3446. (PMID: 35788657) ; Vnitr Lek. 2018 Fall;64(9):834-838. (PMID: 30441995) ; Anatol J Cardiol. 2017 Jan;17(1):24-30. (PMID: 27564775) ; Am Heart J. 2005 Nov;150(5):983. (PMID: 16290976) ; Thyroid. 2012 Jul;22(7):661-79. (PMID: 22690898) ; Clin Chem Lab Med. 2021 Feb 04;59(7):1299-1306. (PMID: 33544524) ; Signal Transduct Target Ther. 2021 Feb 22;6(1):79. (PMID: 33612829) ; J Pharmacol Exp Ther. 2021 Aug;378(2):108-123. (PMID: 34074714) ; Eur J Heart Fail. 2022 Jan;24(1):4-131. (PMID: 35083827) ; Cureus. 2022 Mar 28;14(3):e23582. (PMID: 35494989) ; Int J Cardiol. 2022 Apr 15;353:127-130. (PMID: 35167908) ; Eur J Heart Fail. 2022 Nov;24(11):2000-2018. (PMID: 36065751) ; J Med Biochem. 2023 Jan 20;42(1):9-15. (PMID: 36819129) ; Front Cardiovasc Med. 2022 Aug 11;9:857922. (PMID: 36035940) Contributed Indexing: Keywords: cardiac function; chronic heart failure; correlation; prognosis; revascularization; serum uric acid ; Local Abstract: [Publisher, Serbian] Cilj je bio da se istraži korelacija između serumske mokraćne kiseline (SUA) i prognoze kod pacijenata sa hronićnom srčanom insuficijencijom (CHF) nakon revaskularizacije. [Publisher, Serbian] Ukupno 126 pacijenata sa CHF koji su bili podvrgnuti revaskularizaciji [koronarne arterijske intervencije (PCI) ili koronarne arterijske premosnice (CABG)] u bolnici je upisano kao grupa za CHF između decembra 2021. i oktobra 2022. godine, dok je 126 zdravih kontrola tokom istog perioda su upisani kao zdrava kontrolna grupa. Detektovani su nivoi SUA, inflamatornih faktora i srčane funkcije u dve grupe. Analizirana je korelacija između nivoa SUA i inflamatornih faktora i nivoa srčane funkcije. Svi pacijenti u grupi sa CHF su praćeni 6 meseci da bi se posmatrala prognoza. Upoređene su razlike u navedenim indeksima kod pacijenata sa različitom prognozom. Faktori rizika prognoze analizirani su multivarijantnom logističkom regresionom analizom, a njihova prediktivna vrednost za prognozu procenjena je analizom ROC krive. [Publisher, Serbian] SUA, IL-6, TNF-a, NT-proBNP i LVEDD u grupi sa CHF su bili viši od onih u zdravoj kontrolnoj grupi, dok je LVEF bio niži u odnosu na zdravu kontrolnu grupu (P<0,05). Među 126 pacijenata u roku od 6 meseci nakon operacije, bilo je 24 slučaja (19,05%) sa neželjenim srčanim događajima (loša prognoza). SUA, IL-6, TNF-a, NT-proBNP i LVEDD kod pacijenata sa lošom prognozom bili su veći od onih sa dobrom prognozom, dok je LVEF bio niži od onih sa dobrom prognozom (P<0,05). Nivo SUA je bio u pozitivnoj korelaciji sa IL-6, TNF-a, NT-proBNP i LVEDD (r=0,283, 0,292, 0,322, 0,355, P<0,05), dok je u negativnoj korelaciji sa LVEF (r=-0,368, P<0,05). Visok nivo SUA i nizak LVEF su bili nezavisni faktori rizika prognoze (OR=1,486, 0,678, P<0,05). I SUA i LVEF su bile prognostičke vrednosti (AUC=0,805, 0,809, P<0,05). [Publisher, Serbian] Nivo SUA je značajno povećan kod pacijenata sa CHF, što je nezavisan faktor rizika za lošu prognozu kod pacijenata sa CHF nakon revaskularizacije, sa visokom prognostičkom vrednošću. Entry Date(s): Date Created: 20240503 Latest Revision: 20240504 Update Code: 20240504 PubMed Central ID: PMC11062339

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Correlation between SUA and prognosis in CHF patients after revascularization.