PLA <subscript>2</subscript> -MjTX-II from Bothrops moojeni snake venom exhibits antimetastatic and antiangiogenic effects on human lung cancer cells.

Santos, LC ; Oliveira, VQ ; et al.

In: Toxicon : official journal of the International Society on Toxinology, Jg. 243 (2024-05-28), S. 107742

academicJournal

Phospholipases A 2 (PLA 2 s) from snake venom possess antitumor and antiangiogenic properties. In this study, we evaluated the antimetastatic and antiangiogenic effects of MjTX-II, a Lys49 PLA 2 isolated from Bothrops moojeni venom, on lung cancer and endothelial cells. Using in vitro and ex vivo approaches, we demonstrated that MjTX-II reduced cell proliferation and inhibited fundamental processes for lung cancer cells (A549) growth and metastasis, such as adhesion, migration, invasion, and actin cytoskeleton decrease, without significantly interfering with non-tumorigenic lung cells (BEAS-2B). Furthermore, MjTX-II caused cell cycle alterations, increased reactive oxygen species production, modulated the expression of pro- and antiangiogenic genes, and decreased vascular endothelial growth factor (VEGF) expression in HUVECs. Finally, MjTX-II inhibited ex vivo angiogenesis processes in an aortic ring model. Therefore, we conclude that MjTX-II exhibits antimetastatic and antiangiogenic effects in vitro and ex vivo and represents a molecule that hold promise as a pharmacological model for antitumor therapy.

Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Titel:	PLA <subscript>2</subscript> -MjTX-II from Bothrops moojeni snake venom exhibits antimetastatic and antiangiogenic effects on human lung cancer cells.
Autor/in / Beteiligte Person:	Santos, LC ; Oliveira, VQ ; Teixeira, SC ; Correia, TML ; Andrade, LOSB ; Polloni, L ; Marques, LM ; Clissa, PB ; Baldo, C ; Ferro, EAV ; Gusmão, ACMM ; Silva, MJB ; Sanabani, SS ; Ávila, VMR ; Lopes, DS
Zeitschrift:	Toxicon : official journal of the International Society on Toxinology, Jg. 243 (2024-05-28), S. 107742
Veröffentlichung:	Oxford ; New York : Pergamon Press, c1962-, 2024
Medientyp:	academicJournal
ISSN:	1879-3150 (electronic)
DOI:	10.1016/j.toxicon.2024.107742
Schlagwort:	Animals Humans Phospholipases A2 pharmacology Cell Movement drug effects Human Umbilical Vein Endothelial Cells drug effects Vascular Endothelial Growth Factor A metabolism A549 Cells Cell Line, Tumor Antineoplastic Agents pharmacology Neovascularization, Pathologic drug therapy Reactive Oxygen Species metabolism Venomous Snakes Bothrops Angiogenesis Inhibitors pharmacology Lung Neoplasms drug therapy Crotalid Venoms Cell Proliferation drug effects
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Toxicon] 2024 May 28; Vol. 243, pp. 107742. <i>Date of Electronic Publication: </i>2024 May 04. MeSH Terms: Bothrops* ; Angiogenesis Inhibitors* / pharmacology ; Lung Neoplasms* / drug therapy ; Crotalid Venoms* ; Cell Proliferation* / drug effects ; Animals ; Humans ; Phospholipases A2 / pharmacology ; Cell Movement / drug effects ; Human Umbilical Vein Endothelial Cells / drug effects ; Vascular Endothelial Growth Factor A / metabolism ; A549 Cells ; Cell Line, Tumor ; Antineoplastic Agents / pharmacology ; Neovascularization, Pathologic / drug therapy ; Reactive Oxygen Species / metabolism ; Venomous Snakes Contributed Indexing: Keywords: Angiogenic; Lung cancer; MjTX-II; Phospholipases A(2); Snake venom SCR Organism: Bothrops moojeni Entry Date(s): Date Created: 20240505 Date Completed: 20240517 Latest Revision: 20240517 Update Code: 20240518

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