Gender differences in tumor characteristics, treatment allocation and survival in stage I-III pancreatic cancer: a nationwide study.

Gehrels, AM ; Wagner, AD ; et al.

In: European journal of cancer (Oxford, England : 1990), Jg. 206 (2024-07-01), S. 114117

academicJournal

Introduction: Sex and gender are modulators of health and disease and may have impact on treatment allocation and survival in patients with cancer. In this study, we analyzed the impact of sex and gender on treatment allocation and overall survival in patients with stage I-III pancreatic cancer.

Methods: Patients with stage I-III pancreatic cancer diagnosed between 2015 and 2020 were selected from the nationwide Netherlands Cancer Registry. Associations between sex and gender and the probability of receiving surgical and/or systemic treatment were examined with multivariable logistic regression analyses. Overall survival was assessed with log rank test and multivariable Cox proportional hazard analysis.

Results: Among 6855 patients, 51.2 % were female. Multivariable logistic regression analyses with adjustment for known confounders (age, performance status, comorbidities, tumor location, tumor stage and previous malignancies) showed that females less often received systemic chemotherapy compared to males (OR 0.799, 95 %CI 0.703-0.909, p < .001). No difference was found in the probability for undergoing surgical resection. Furthermore, females had worse overall survival compared to males (median OS 8.5 and 9.2 months respectively, 95 %CI 8.669-9.731).

Conclusion: This nationwide study found that female patients with stage I-III pancreatic cancer significantly less often received systemic treatment and had worse overall survival as compared to males. Disparities in pancreatic cancer care can be decreased by recognizing and resolving potential obstacles or biases in treatment decision-making.

Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Titel:	Gender differences in tumor characteristics, treatment allocation and survival in stage I-III pancreatic cancer: a nationwide study.
Autor/in / Beteiligte Person:	Gehrels, AM ; Wagner, AD ; Besselink, MG ; Verhoeven, RHA ; van Eijck CHJ ; van Laarhoven HWM ; Wilmink, JW ; van der Geest LG
Zeitschrift:	European journal of cancer (Oxford, England : 1990), Jg. 206 (2024-07-01), S. 114117
Veröffentlichung:	Oxford : Elsevier Science Ltd ; <i>Original Publication</i>: Oxford ; New York : Pergamon Press, c1990-, 2024
Medientyp:	academicJournal
ISSN:	1879-0852 (electronic)
DOI:	10.1016/j.ejca.2024.114117
Schlagwort:	Humans Female Male Aged Middle Aged Netherlands epidemiology Sex Factors Registries statistics & numerical data Healthcare Disparities statistics & numerical data Aged, 80 and over Survival Rate Pancreatic Neoplasms mortality Pancreatic Neoplasms therapy Pancreatic Neoplasms pathology Neoplasm Staging
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Corporate Authors: Dutch Pancreatic Cancer Group Publication Type: Journal Article Language: English [Eur J Cancer] 2024 Jul; Vol. 206, pp. 114117. <i>Date of Electronic Publication: </i>2024 May 14. MeSH Terms: Pancreatic Neoplasms* / mortality ; Pancreatic Neoplasms* / therapy ; Pancreatic Neoplasms* / pathology ; Neoplasm Staging* ; Humans ; Female ; Male ; Aged ; Middle Aged ; Netherlands / epidemiology ; Sex Factors ; Registries / statistics & numerical data ; Healthcare Disparities / statistics & numerical data ; Aged, 80 and over ; Survival Rate Contributed Indexing: Keywords: Gender identity; Localized pancreatic cancer; Pancreatic neoplasms; Sex; Surgical resection; Systemic treatment Entry Date(s): Date Created: 20240523 Date Completed: 20240615 Latest Revision: 20240615 Update Code: 20240616

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