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Recent studies have shown that Bordetella bronchiseptica utilizes a siderophore-mediated transport system for acquisition of iron from the host iron-binding proteins lactoferrin and transferrin. We recently identified the B. bronchiseptica siderophore as alcaligin, which is also produced by B. pertussis. Alcaligin production by B. bronchiseptica is repressed by exogenous iron, a phenotype of other microbes that produce siderophores. In this study, we report that alcaligin production by B. bronchiseptica RB50 and GP1SN was repressed by the Bordetella global virulence regulator, bvg, in addition to being Fe repressed. Modulation of bvg locus expression with 50 mM MgSO4 or inactivation of bvg by deletion allowed strain RB50 to produce alcaligin. In modulated organisms, siderophore production remained Fe repressed. These observations contrasted with our previous data indicating that alcaligin production by B. bronchiseptica MBORD846 and B. pertussis was repressed by Fe but bvg independent. Despite bvg repression of alcaligin production, strain RB50 was still able to acquire Fe from purified alcaligin, suggesting that expression of the bacterial alcaligin receptor was not repressed by bvg. We tested 114 B. bronchiseptica strains and found that bvg repression of alcaligin production was strongly associated with Bordetella phylogenetic lineage and with host species from which the organisms were isolated.

Titel:	bvg Repression of alcaligin synthesis in Bordetella bronchiseptica is associated with phylogenetic lineage.
Autor/in / Beteiligte Person:	Giardina, PC ; Foster, LA ; Musser, JM ; Akerley, BJ ; Miller, JF ; Dyer, DW
Link:	Full Text Finder (Volltext)
Zeitschrift:	Journal of bacteriology, Jg. 177 (1995-11-01), Heft 21, S. 6058-63
Veröffentlichung:	Washington, DC : American Society for Microbiology, 1995
Medientyp:	academicJournal
ISSN:	0021-9193 (print)
DOI:	10.1128/jb.177.21.6058-6063.1995
Schlagwort:	Bordetella bronchiseptica classification Iron metabolism Iron pharmacology Lactoferrin metabolism Magnesium Sulfate pharmacology Phylogeny Species Specificity Bacterial Proteins genetics Bordetella bronchiseptica genetics Gene Expression Regulation, Bacterial Hydroxamic Acids Siderophores biosynthesis Trans-Activators genetics
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. Language: English [J Bacteriol] 1995 Nov; Vol. 177 (21), pp. 6058-63. MeSH Terms: Gene Expression Regulation, Bacterial* ; Hydroxamic Acids* ; Bacterial Proteins / genetics ; Bordetella bronchiseptica / genetics ; Siderophores / biosynthesis ; Trans-Activators / genetics ; Bordetella bronchiseptica / classification ; Iron / metabolism ; Iron / pharmacology ; Lactoferrin / metabolism ; Magnesium Sulfate / pharmacology ; Phylogeny ; Species Specificity References: Infect Immun. 1991 Sep;59(9):3273-9. (PMID: 1652562) ; Infection. 1991 Jan-Feb;19(1):46-8. (PMID: 2013509) ; Infect Immun. 1992 Jan;60(1):117-23. (PMID: 1309510) ; Infect Immun. 1992 Feb;60(2):571-7. (PMID: 1730491) ; J Bacteriol. 1992 Feb;174(3):970-9. (PMID: 1732230) ; J Bacteriol. 1992 Feb;174(3):980-90. (PMID: 1370665) ; Pediatrics. 1992 Jun;89(6 Pt 2):1262-5. (PMID: 1534404) ; Vet Clin North Am Small Anim Pract. 1992 Sep;22(5):1173-86. (PMID: 1523788) ; J Bacteriol. 1993 Feb;175(4):1144-52. (PMID: 8381782) ; Infect Immun. 1993 Jun;61(6):2698-702. (PMID: 8500910) ; J Bacteriol. 1993 Jun;175(11):3468-79. (PMID: 8501051) ; Mol Microbiol. 1993 May;8(3):429-34. (PMID: 8326857) ; Nucleic Acids Res. 1993 Jul 11;21(14):3320. (PMID: 7688118) ; FEMS Microbiol Lett. 1993 Aug 1;111(2-3):225-31. (PMID: 8405931) ; Vet Microbiol. 1993 Nov;37(3-4):353-68. (PMID: 8116191) ; Infect Immun. 1994 Aug;62(8):3381-90. (PMID: 8039908) ; Thorax. 1994 Jul;49(7):719-20. (PMID: 8066571) ; Annu Rev Microbiol. 1994;48:743-72. (PMID: 7826025) ; J Bacteriol. 1995 Feb;177(4):1116-8. (PMID: 7860593) ; Cell. 1995 Feb 24;80(4):611-20. (PMID: 7867068) ; Am J Vet Res. 1956 Jul;17(64):478-84. (PMID: 13340110) ; Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):1163-7. (PMID: 8302847) ; Infect Immun. 1987 Mar;55(3):497-501. (PMID: 3818081) ; Anal Biochem. 1987 Jan;160(1):47-56. (PMID: 2952030) ; J Bacteriol. 1987 Jun;169(6):2793-803. (PMID: 3584070) ; J Bacteriol. 1987 Jun;169(6):2847-53. (PMID: 3584073) ; Mol Microbiol. 1988 Jan;2(1):19-30. (PMID: 2897067) ; Proc Natl Acad Sci U S A. 1989 Apr;86(8):2637-41. (PMID: 2539596) ; Mol Microbiol. 1989 Jan;3(1):119-24. (PMID: 2654538) ; Infect Immun. 1989 Sep;57(9):2674-82. (PMID: 2569447) ; Res Vet Sci. 1989 Jul;47(1):48-53. (PMID: 2772406) ; Can Vet J. 1966 Nov;7(11):243-51. (PMID: 5342450) ; J Gen Microbiol. 1970 Oct;63(2):211-20. (PMID: 4324651) ; Vet Rec. 1973 Nov 3;93(18):486-7. (PMID: 4594840) ; Res Vet Sci. 1976 Jan;20(1):16-23. (PMID: 1257623) ; Microbiol Rev. 1978 Mar;42(1):45-66. (PMID: 379572) ; Microbiol Rev. 1980 Dec;44(4):722-38. (PMID: 7010115) ; Annu Rev Biochem. 1981;50:715-31. (PMID: 6455965) ; J Med Microbiol. 1984 Feb;17(1):91-103. (PMID: 6319705) ; Infect Immun. 1986 Mar;51(3):942-7. (PMID: 2936686) ; J Bacteriol. 1986 Apr;166(1):230-7. (PMID: 3957867) ; FEMS Microbiol Lett. 1990 Jan 1;54(1-3):101-5. (PMID: 2138989) ; Proc Natl Acad Sci U S A. 1990 May;87(10):3763-7. (PMID: 2111016) ; APMIS. 1990 May;98(5):453-61. (PMID: 2357345) ; EMBO J. 1990 Sep;9(9):2803-9. (PMID: 1975238) ; Proc Natl Acad Sci U S A. 1990 Sep;87(17):6753-7. (PMID: 1697687) ; Drug Metab Rev. 1990;22(5):531-79. (PMID: 2078994) ; Clin Microbiol Rev. 1991 Jul;4(3):243-55. (PMID: 1889042) Grant Information: A131548 United States PHS HHS Substance Nomenclature: 0 (Bacterial Proteins) ; 0 (Bvg accessory factor protein, Bordetella pertussis) ; 0 (Hydroxamic Acids) ; 0 (Siderophores) ; 0 (Trans-Activators) ; 0 (alcaligin) ; 7487-88-9 (Magnesium Sulfate) ; E1UOL152H7 (Iron) ; EC 3.4.21.- (Lactoferrin) Entry Date(s): Date Created: 19951101 Date Completed: 19951207 Latest Revision: 20190508 Update Code: 20231215 PubMed Central ID: PMC177442

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bvg Repression of alcaligin synthesis in Bordetella bronchiseptica is associated with phylogenetic lineage.